Professor, Internal Medicine, Virginia Commonwealth U SOM

Gastroenterology

Dr. William M. Pandak Jr. practices Gastroenterology. He went to Virginia Commonwealth University School of Medicine. He has 2 awards "Fellow (AGAF)" and "Fellow (FACP)". Dr. William M. Pandak Jr. is a published physician. He published 45 publications, including: 'Conjugated Bile Acid Activated S1P Receptor 2 Is a Key Regulator of Sphingosine Kinase 2 and Hepatic Gene Expression.'

Publications

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• Conjugated Bile Acid Activated S1P Receptor 2 Is a Key Regulator of Sphingosine Kinase 2 and Hepatic Gene Expression.
• Colonic inflammation and secondary bile acids in alcoholic cirrhosis.
• Randomised clinical trial: Lactobacillus GG modulates gut microbiome, metabolome and endotoxemia in patients with cirrhosis.
• Development of a simple and accurate HPLC method for measurement of fecal bile acids: validation by GC-MS and LC-MS and application in healthy and cirrhotic patients.
• Conjugated bile acids promote cholangiocarcinoma cell invasive growth via activation of sphingosine 1-phosphate receptor 2.
• The StarD4 subfamily of steroidogenic acute regulatory-related lipid transfer (START) domain proteins: New players in cholesterol metabolism.
• 5-cholesten-3?,25-diol 3-sulfate decreases lipid accumulation in diet-induced nonalcoholic Fatty liver Disease mouse model.
• Safety and Tolerability of Human Placenta-Derived Cells (PDA001) in Treatment-Resistant Crohn's Disease: A Phase 1 Study.
• Inhibition of P-Glycoprotein by HIV Protease Inhibitors Increases Intracellular Accumulation of Berberine in Murine and Human Macrophages.
• Modulation of the fecal bile acid profile by gut microbiota in cirrhosis.
• ER stress increases StarD5 expression by stabilizing its mRNA and leads to relocalization of its protein from the nucleus to the membranes.
• The role of CCAAT enhancer-binding protein homologous protein in human immunodeficiency virus protease-inhibitor-induced hepatic lipotoxicity in mice.
• Cholesterol metabolite, 5-cholesten-3β-25-diol-3-sulfate, promotes hepatic proliferation in mice.
• Cytosolic Sulfotransferase 2B1b Promotes Hepatocyte Proliferation Gene Expression In Vivo And In Vitro.
• Oxysterol sulfation by cytosolic sulfotransferase suppresses liver X receptor/sterol regulatory element binding protein-1c signaling pathway and reduces serum and hepa...
• Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes.
• Bile acids regulate hepatic gluconeogenic genes and farnesoid X receptor via G(alpha)i-protein-coupled receptors and the AKT pathway.
• Prevention of HIV protease inhibitor-induced dysregulation of hepatic lipid metabolism by raltegravir via endoplasmic reticulum stress signaling pathways.
• α(1)-Fetoprotein Transcription Factor (FTF)/Liver Receptor Homolog-1 (LRH-1) Is an Essential Lipogenic Regulator.
• Berberine inhibits HIV protease inhibitor-induced inflammatory response by modulating ER stress signaling pathways in murine macrophages.
• HIV protease inhibitors induce endoplasmic reticulum stress and disrupt barrier integrity in Intestinal epithelial cells.
• Bile acids as regulatory molecules.
• 25-Hydroxycholesterol-3-sulfate regulates macrophage lipid metabolism via the LXR/SREBP-1 signaling pathway.
• Intracellular cholesterol transporter StarD4 binds free cholesterol and increases cholesteryl ester formation.
• Prevention of free fatty acid-induced hepatic lipotoxicity by 18beta-glycyrrhetinic acid through lysosomal and mitochondrial pathways.
• Biosynthesis of the regulatory oxysterol, 5-cholesten-3beta,25-diol 3-sulfate, in hepatocytes.
• Sulfated oxysterol, 25HC3S, is a potent regulator of lipid metabolism in human hepatocytes.
• Activation of bile acid biosynthesis by the p38 mitogen-activated protein kinase (MAPK): hepatocyte nuclear factor-4alpha phosphorylation by the p38 MAPK is required f...
• Conjugated bile acids regulate hepatocyte glycogen synthase activity in vitro and in vivo via Galphai signaling.
• HIV protease inhibitors activate the unfolded protein response and disrupt lipid metabolism in primary hepatocytes.
• Enzyme activity assay for cholesterol 27-hydroxylase in mitochondria.
• Localization of StarD5 cholesterol binding protein.
• Identification of a novel sulfonated oxysterol, 5-cholesten-3beta,25-diol 3-sulfonate, in hepatocyte nuclei and mitochondria.
• HIV protease inhibitors activate the unfolded protein response in macrophages: implication for atherosclerosis and cardiovascular Disease.
• Human StarD5, a cytosolic StAR-related lipid binding protein.
• Effect of increasing the expression of cholesterol transporters (StAR, MLN64, and SCP-2) on bile acid synthesis.
• Overexpression of cholesterol transporter StAR increases in vivo rates of bile acid synthesis in the rat and mouse.
• The role of alpha1-fetoprotein transcription factor/LRH-1 in bile acid biosynthesis: a known nuclear receptor activator that can act as a suppressor of bile acid biosy...
• Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in the rat.
• Transport of cholesterol into mitochondria is rate-limiting for bile acid synthesis via the alternative pathway in primary rat hepatocytes.
• Short course of omeprazole: a better first diagnostic approach to noncardiac chest pain than endoscopy, manometry, or 24-hour Esophageal pH monitoring.
• Regulation of oxysterol 7alpha-hydroxylase (CYP7B1) in primary cultures of rat hepatocytes.
• LXR alpha is the dominant regulator of CYP7A1 transcription.
• Reduction of the HIV Protease Inhibitor-Induced ER Stress and Inflammatory Response by Raltegravir in Macrophages.

Schools

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• Virginia Commonwealth University Medical College Of Virginia School Of Medicine

• Med College Va

Procedures Preformed

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• Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy

Conditions Treated

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• Anemia
• Biliary Atresia
• Cholecystitis and Gallstones
• Crohn's Disease (Regional Enteritis)
• View All

Doctors Specialties

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• Gastroenterology

Accepted Insurances

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Awards

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• Fellow (AGAF)
• Fellow (FACP)

Education

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• Virginia Commonwealth University Health System
• Virginia Commonwealth University School of Medicine

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