Associate Professor, Biochemistry, Molecular Biology and Biophysics, University of Minn Medical School
Internal Medicine
Dr. Timothy J. Griffin, MD
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Timothy Griffin is an expert in the field of Internal Medicine. He went to medical school at Creighton University School of Medicine. Creighton University School of Medicine has a rank of 79 in research and a 78 in primary care He has 1 awards "CMS Meaningful Use Stage 1 Certification". Timothy Griffin has written publications. He has 52 publications published with PubMed. The lastest publication is: 'Tn552 transposase catalyzes concerted strand transfer in vitro.'
Publications
- Characterizing Cardiac Molecular Mechanisms of Mammalian Hibernation via Quantitative Proteogenomics.
- Using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry to detect monoclonal immunoglobulin light chains in serum and urine.
- Multi-omic data analysis using Galaxy.
- Salivary proteomics in bisphosphonate-related osteonecrosis of the jaw.
- Flexible and accessible workflows for improved proteogenomic analysis using the galaxy framework.
- Improved Intensity-Based Label-Free Quantification via Proximity-Based Intensity Normalization (PIN).
- Mass spectrometry-based proteomics: basic principles and emerging technologies and directions.
- A two-step database search method improves sensitivity in peptide sequence matches for metaproteomics and proteogenomics studies.
- Sample collection and handling considerations for peptidomic studies in whole saliva; implications for biomarker discovery.
- Large-scale phosphoproteomics analysis of whole saliva reveals a distinct phosphorylation pattern.
- Hexapeptide libraries for enhanced protein PTM identification and relative abundance profiling in whole human saliva.
- Three-Dimensional Peptide Fractionation for Highly Sensitive Nanoscale LC-Based Shotgun Proteomic Analysis of Complex Protein Mixtures.
- Mass spectrometric identification of phosphorylation sites in guanylyl cyclase A and B.
- Novel In Situ Collection of Tumor Interstitial Fluid from a Head and Neck Squamous Carcinoma Reveals a Unique Proteome with Diagnostic Potential.
- Targeted 18O-labeling for improved proteomic analysis of carbonylated peptides by mass spectrometry.
- Multitagging proteomic strategy to estimate protein turnover rates in dynamic systems.
- Quantitative nuclear proteomics identifies mTOR regulation of DNA damage response.
- Quantitative proteomics reveals myosin and actin as promising saliva biomarkers for distinguishing pre-malignant and malignant oral lesions.
- A dynamic range compression and three-dimensional peptide fractionation analysis platform expands proteome coverage and the diagnostic potential of whole saliva.
- Systematic comparison of the human saliva and plasma proteomes.
- Quantitative proteomic profiling of muscle type-dependent and age-dependent protein carbonylation in rat skeletal muscle mitochondria.
- Oxidative stress and covalent modification of protein with bioactive aldehydes.
- Proteomics analysis of cells in whole saliva from oral cancer patients via value-added three-dimensional peptide fractionation and tandem mass spectrometry.
- Hsf1 activation inhibits rapamycin resistance and TOR signaling in yeast revealed by combined proteomic and genetic analysis.
- Uncovering genes with divergent mRNA-protein dynamics in Streptomyces coelicolor.
- iTRAQ reagent-based quantitative proteomic analysis on a linear ion trap mass spectrometer.
- PRR5, a novel component of mTOR complex 2, regulates platelet-derived growth factor receptor beta expression and signaling.
- Proteomic mapping of 4-hydroxynonenal protein modification sites by solid-phase hydrazide chemistry and mass spectrometry.
- Preparative peptide isoelectric focusing as a tool for improving the identification of lysine-acetylated peptides from complex mixtures.
- Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal.
- Isotope-coded affinity tagging of proteins.
- Trade-off between high sensitivity and increased potential for false positive peptide sequence matches using a two-dimensional linear ion trap for tandem mass spectrom...
- A catalogue of human saliva proteins identified by free flow electrophoresis-based peptide separation and tandem mass spectrometry.
- Evaluating preparative isoelectric focusing of complex peptide mixtures for tandem mass spectrometry-based proteomics: a case study in profiling chromatin-enriched sub...
- Abundance ratio-dependent proteomic analysis by mass spectrometry.
- Development of a multiplexed microcapillary liquid chromatography system for high-throughput proteome analysis.
- Complementary profiling of gene expression at the transcriptome and proteome levels in Saccharomyces cerevisiae.
- Proteome analysis of low-abundance proteins using multidimensional chromatography and isotope-coded affinity tags.
- Quantitative proteomic analysis of oral brush biopsies identifies secretory leukocyte protease inhibitor as a promising, mechanism-based oral cancer biomarker.
- In vitro transposition of Tn552: a tool for DNA sequencing and mutagenesis.
- Tn552 transposase catalyzes concerted strand transfer in vitro.
- Purification and preliminary characterization of the Escherichia coli K-12 recF protein.
- Advances in quantitative proteomics using stable isotope tags.
- Gel-free mass spectrometry-based high throughput proteomics: tools for studying biological response of proteins and proteomes.
- Global assessment of protein turnover in recombinant antibody producing myeloma cells.
- Advancing mammalian cell culture engineering using genome-scale technologies.
- Identification of carbonylated proteins from enriched rat skeletal muscle mitochondria using affinity chromatography-stable isotope labeling and tandem mass spectrometry.
- Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40.
- LTQ-iQuant: A freely available software pipeline for automated and accurate protein quantification of isobaric tagged peptide data from LTQ instruments.
- Dynamic range compression: a solution for proteomic biomarker discovery?
- Evaluating the potential of a novel oral lesion exudate collection method coupled with mass spectrometry-based proteomics for oral cancer biomarker discovery.
Schools
Creighton University School Of Medicine
Creighton University Medical Center
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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Creighton University -
Creighton University School of Medicine
Hospital
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Veterans Affairs Nebraska-Western Iowa Health Care System
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