Professor of Ophthalmology, Baylor College of Medicine
Ophthalmology
Dr. Stephen C. Pflugfelder, MD
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Stephen Pflugfelder works in the field of Ophthalmology. He attended Baylor College of Medicine. He has 6 awards "America's Top Doctors", "Top Doctors:SE Texas", "CMS Meaningful Use Stage 1 Certification", "Fellow (FAAO)", "Top MD" and "Super Doctor". Stephen C. Pflugfelder, MD is also published. He has 101 publications published. The lastest publication: "Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease.'
Publications
- Acute and Chronic Ophthalmic Involvement in Stevens-Johnson Syndrome/Toxic Epidermal Necrolysis - A Comprehensive Review and Guide to Therapy. II. Ophthalmic Disease.
- Protective Effects of L-Carnitine Against Oxidative Injury by Hyperosmolarity in Human Corneal Epithelial Cells.
- Effects of Azithromycin on Gene Expression Profiles of Proinflammatory and Anti-inflammatory Mediators in the Eyelid Margin and Conjunctiva of Patients With Meibomian ...
- Age-related Conjunctival disease in the C57BL/6.NOD-Aec1Aec2 Mouse Model of Sjögren Syndrome develops independent of lacrimal dysfunction.
- Ocular drug delivery nanowafer with enhanced therapeutic efficacy.
- Effects of l-Carnitine, Erythritol and Betaine on Pro-inflammatory Markers in Primary Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress.
- Desiccating Stress-Induced Chemokine Expression in the Epithelium Is Dependent on Upregulation of NKG2D/RAE-1 and Release of IFN-γ in Experimental Dry Eye.
- Mucosal environmental sensors in the pathogenesis of dry eye.
- Effect of loteprednol etabonate 0.5% on initiation of dry eye treatment with topical cyclosporine 0.05%.
- New testing options for diagnosing and grading dry eye disease.
- A potential link between bacterial pathogens and allergic Conjunctivitis by dendritic cells.
- What causes dryness in Sjögren syndome patients and how can it be targeted?
- Topical interferon-gamma neutralization prevents Conjunctival goblet cell loss in experimental murine dry eye.
- Ocular Surface Disease and Dacryoadenitis in Aging C57BL/6 Mice.
- Atopic keratoConjunctivitis: A review.
- Tear Meniscus Dimensions in Tear Dysfunction and Their Correlation With Clinical Parameters.
- CD8(+) cells regulate the T helper-17 response in an experimental murine model of Sjögren Syndrome.
- T helper cytokines in dry eye disease.
- Dendritic cell-derived thrombospondin-1 is critical for the generation of the Ocular surface Th17 response to desiccating stress.
- Long-term Supplementation With n-6 and n-3 PUFAs Improves Moderate-to-Severe KeratoConjunctivitis Sicca: A Randomized Double-Blind Clinical Trial.
- Factors Predicting the Ocular Surface Response to Desiccating Environmental Stress.
- Patient Ocular conditions and clinical outcomes using a PROSE scleral device.
- Dry eye as a mucosal autoimmune disease.
- Toll-Like Receptor Expression and Activation in Mice with Experimental Dry Eye.
- Potential autocrine regulation of interleukin-33/ST2 signaling of dendritic cells in allergic inflammation.
- PROSE Therapy Used to Minimize Corneal Trauma in Patients With Corneal Epithelial Defects.
- A native-like Corneal construct using donor Corneal stroma for tissue engineering.
- Morphologic Alterations of the Palpebral Conjunctival Epithelium in a Dry Eye Model.
- Increasing Prevalence and Severity of Conjunctivochalasis With Aging Detected by Anterior Segment Optical Coherence Tomography.
- NK cells promote th-17 mediated Corneal barrier disruption in dry eye.
- Resolvin E1 (RX-10001) Reduces Corneal Epithelial Barrier Disruption and Protects Against Goblet Cell Loss in a Murine Model of Dry Eye.
- Transcription Factor TCF4 Maintains the Properties of Human Corneal Epithelial Stem Cells.
- Tear Dysfunction and the Cornea: LXVII Edward Jackson Memorial Lecture.
- Ocular Surface APCs Are Necessary for Autoreactive T Cell-Mediated Experimental Autoimmune Lacrimal Keratoconjunctivitis.
- Desiccating stress induces CD4+ T-cell-mediated Sjögren's syndrome-like Corneal epithelial apoptosis via activation of the extrinsic apoptotic pathway by interferon-γ.
- Short ragweed pollen triggers allergic inflammation through Toll-like receptor 4-dependent thymic stromal lymphopoietin/OX40 ligand/OX40 signaling pathways.
- TLR-mediated induction of pro-allergic cytokine IL-33 in Ocular mucosal epithelium.
- Interferon-γ exacerbates dry eye-induced apoptosis in conjunctiva through dual apoptotic pathways.
- The impact of the Boston Ocular surface prosthesis on wavefront higher-order aberrations.
- Entrapment of Conjunctival Goblet Cells by Desiccation-Induced Cornification.
- Disruption of TGF-? Signaling Improves Ocular Surface Epithelial Disease in Experimental Autoimmune Keratoconjunctivitis Sicca.
- Noninvasive assessment of tear stability with the tear stability analysis system in tear dysfunction patients.
- Pharmacological cholinergic blockade stimulates inflammatory cytokine production and lymphocytic infiltration in the mouse lacrimal gland.
- The successful use of Boston ocular surface prosthesis in the treatment of persistent Corneal epithelial defect after herpes zoster ophthalmicus.
- Anterior segment optical coherence tomography: a diagnostic instrument for conjunctivochalasis.
- An immunoprotective privilege of Corneal epithelial stem cells against Th17 inflammatory stress by producing glial cell-derived neurotrophic factor.
- Altered morphology and function of the lacrimal functional unit in protein kinase C{alpha} knockout mice.
- Suppressive effects of azithromycin on zymosan-induced production of proinflammatory mediators by human Corneal epithelial cells.
- Potential localization of putative stem/progenitor cells in human bulbar Conjunctival epithelium.
- Evaluation of the transforming growth factor-beta activity in normal and dry eye human tears by CCL-185 cell bioassay.
- Multicenter open-label study evaluating the efficacy of azithromycin ophthalmic solution 1% on the signs and symptoms of subjects with Blepharitis.
- Spontaneous autoimmune dacryoadenitis in aged CD25KO mice.
- Post-LASIK tear dysfunction and dysesthesia.
- TSLP and downstream molecules in experimental mouse allergic Conjunctivitis.
- Desiccating stress promotion of Th17 differentiation by Ocular surface tissues through a dendritic cell-mediated pathway.
- Association between high tear epidermal growth factor levels and Corneal subepithelial fibrosis in dry eye conditions.
- Expression of CXCL9, -10, -11, and CXCR3 in the tear film and Ocular surface of patients with dry eye syndrome.
- Induction of Th17 differentiation by Corneal epithelial-derived cytokines.
- Minimal clinically important difference for the Ocular surface disease index.
- Essential role for c-Jun N-terminal kinase 2 in Corneal epithelial response to desiccating stress.
- Corneal epithelial opacity in dysfunctional tear syndrome.
- Production and activity of matrix metalloproteinase-9 on the Ocular surface increase in dysfunctional tear syndrome.
- Human Corneal epithelium-derived thymic stromal lymphopoietin links the innate and adaptive immune responses via TLRs and Th2 cytokines.
- Topical ophthalmic cyclosporine: pharmacology and clinical uses.
- Tear cytokine profiles in dysfunctional tear Syndrome.
- In vitro expanded CD4+CD25+Foxp3+ regulatory T cells maintain a normal phenotype and suppress immune-mediated Ocular surface inflammation.
- Desiccating stress decreases apical Corneal epithelial cell size--modulation by the metalloproteinase inhibitor doxycycline.
- Effects of contact Lens multipurpose solutions on human corneal epithelial survival and barrier function.
- Epithelial-immune cell interaction in dry eye.
- Interleukin-1 receptor-1-deficient mice show attenuated production of Ocular surface inflammatory cytokines in experimental dry eye.
- Effects of osmoprotectants on hyperosmolar stress in cultured human Corneal epithelial cells.
- Prevalence, burden, and pharmacoeconomics of dry eye disease.
- Bilateral acanthamoeba Keratitis.
- Hyperosmolarity-induced cornification of human Corneal epithelial cells is regulated by JNK MAPK.
- Effects of sequential artificial tear and cyclosporine emulsion therapy on Conjunctival goblet cell density and transforming growth factor-beta2 production.
- Future directions in therapeutic interventions for conjunctival inflammatory Disorders.
- Strain-related cytokine profiles on the murine Ocular surface in response to desiccating stress.
- Dry eye-induced Conjunctival epithelial squamous metaplasia is modulated by interferon-gamma.
- Expression of Th-1 chemokines and chemokine receptors on the Ocular surface of C57BL/6 mice: effects of desiccating stress.
- Hyperosmolarity-induced apoptosis in human Corneal epithelial cells is mediated by cytochrome c and MAPK pathways.
- Prominent Corneal nerves in a patient with multiple myeloma.
- Patterned expression of neurotrophic factors and receptors in human limbal and Corneal regions.
- Effect of topical ophthalmic epinastine and olopatadine on tear volume in mice.
- Transglutaminase participates in UVB-induced cell death pathways in human Corneal epithelial cells.
- Is autologous serum a tonic for the ailing Corneal epithelium?
- Desiccating stress stimulates expression of matrix metalloproteinases by the Corneal epithelium.
- Apical Corneal barrier disruption in experimental murine dry eye is abrogated by methylprednisolone and doxycycline.
- Gap junction protein connexin 43 serves as a negative marker for a stem cell-containing population of human limbal epithelial cells.
- Expression and regulation of cornified envelope proteins in human Corneal epithelium.
- Desiccating stress induces T cell-mediated Sjögren's Syndrome-like lacrimal keratoConjunctivitis.
- The incidence and risk factors for developing dry eye after myopic LASIK.
- Cell size correlates with phenotype and proliferative capacity in human Corneal epithelial cells.
- Targeted inhibition of p57 and p15 blocks transforming growth factor beta-inhibited proliferation of primary cultured human limbal epithelial cells.
- Integrating restasis into the management of dry eye.
- Phase III safety evaluation of cyclosporine 0.1% ophthalmic emulsion administered twice daily to dry eye disease patients for up to 3 years.
- Stress-activated protein kinase signaling pathways in dry eye and Ocular surface disease.
- Evaluation of ocular surface inflammation in the presence of dry eye and allergic Conjunctival disease.
- Matrix metalloproteinases in Corneal inflammation.
- Pathways of Corneal and ocular surface inflammation: a perspective from the cullen symposium.
- Hyperosmolar saline is a proinflammatory stress on the mouse Ocular surface.
Schools
SUNY Upstate Medical University Syracuse
Presby University Penn
Baylor College Of Med
Bascom Palmer Eye Institute University Mi
Procedures Preformed
- Cataract Removal Surgery
- Excision or Destruction of Lesion of Cornea
- Eyelid Surgery
- Ocular Surface Reconstruction
Conditions Treated
- Age-Related Macular Degeneration
- Aphakia and Other Disorders of Lens
- Astigmatism
- Blepharitis
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Doctors Specialties
- Ophthalmology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Blue Card PPO
- Blue Choice
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- LocalPlus
- Open Access Plus
- Choice Care PPO
- Preferred PPO
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- America's Top Doctors
- Top Doctors:SE Texas
- CMS Meaningful Use Stage 1 Certification
- Fellow (FAAO)
- Top MD
- Super Doctor
Education
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Baylor College of Medicine -
University of Pennsylvania -
State University of New York Upstate Medical University
Hospital
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Texas Children's Hospital -
Michael E. DeBakey Veterans Affairs Medical Center
Drug Facts
| NPI NUMBER | 1851380216 | |
| NPPES Provider LastName | PFLUGFELDER | |
| NPPES Provider FirstName | STEPHEN | |
| NPPES Provider ZIPCode | 770302717 | |
| NPPES Provider State | TX | |
| Specialty Description | Ophthalmology | |
| Total Claim Count | 1182.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1851380216 |
| Last Name Of The Provider | PFLUGFELDER |
| First Name Of The Provider | STEPHEN |
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