Physician
Internal Medicine
Dr. Stephen B. Liggett, MD
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Stephen Liggett practices Internal Medicine. He went to University of Miami Miller School of Medicine. University of Miami Miller School of Medicine is ranked 45/0 in Research/PrimaryCare. He received 2 awards: "Elected Member" and "Whos Who in Medicine and Healthcare". Dr. Stephen B. Liggett has written publications. He has 85 publications published with PubMed. The lastest paper is: 'Race, Common Genetic Variation, and Therapeutic Response Disparities in Heart Failure.'
Publications
- Race, Common Genetic Variation, and Therapeutic Response Disparities in Heart Failure.
- Targeted transgenesis identifies Gαs as the bottleneck in β2-adrenengic receptor cell signaling and physiologic function in airway smooth muscle.
- Polymorphisms in human heat shock factor-1 and analysis of potential biological consequences.
- Bitter Taste Receptor Function in Asthmatic and Nonasthmatic Human Airway Smooth Muscle Cells.
- Prevention of Atrial Fibrillation by Bucindolol Is Dependent on the Beta1389 Arg/Gly Adrenergic Receptor Polymorphism.
- Bitter taste receptors on airway smooth muscle as targets for novel bronchodilators.
- A polymorphism in the thyroid hormone receptor gene is associated with bronchodilator response in asthmatics.
- Adrenergic receptor polymorphisms and prevention of ventricular arrhythmias with bucindolol in patients with chronic heart failure.
- Extraoral bitter taste receptors as mediators of off-target drug effects.
- G protein receptor kinase 4 polymorphisms: β-blocker pharmacogenetics and treatment-related outcomes in hypertension.
- Temporal Analysis of mRNA and miRNA Expression in Transgenic Mice Over Expressing Arg- and Gly389 Polymorphic Variants of the {beta}1-Adrenergic Receptor.
- Genetic variation, ?-blockers, and perioperative myocardial infarction.
- Phosphorylation Barcoding as a Mechanism of Directing GPCR Signaling.
- Agonist-Promoted Homologous Desensitization of Human Airway Smooth Muscle Bitter Taste Receptors.
- Molecular modeling, organ culture and reverse genetics for a newly identified human rhinovirus C.
- MicroRNA let-7 establishes expression of {beta}2-adrenergic receptors and dynamically down-regulates agonist-promoted down-regulation.
- Paradoxical attenuation of β2-AR function in airway smooth muscle by Gi-mediated counterregulation in transgenic mice overexpressing type 5 adenylyl cyclase.
- Regulatory haplotypes in ARG1 are associated with altered bronchodilator response.
- Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.
- Bronchodilator activity of bitter tastants in human tissue.
- β2-Agonist induced cAMP is decreased in asthmatic airway smooth muscle due to increased PDE4D.
- Bitter taste receptors on airway smooth muscle bronchodilate by localized calcium signaling and reverse obstruction.
- Analysis of the complete genome sequences of human rhinovirus.
- Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform.
- An alpha2C-adrenergic receptor polymorphism alters the norepinephrine-lowering effects and therapeutic response of the beta-blocker bucindolol in chronic heart failure.
- Pharmacogenomics of beta1-adrenergic receptor polymorphisms in heart failure.
- Common ADRB2 haplotypes derived from 26 polymorphic sites direct beta2-adrenergic receptor expression and regulation phenotypes.
- alpha2A-adrenergic receptors in the genetics, pathogenesis, and treatment of type 2 diabetes.
- Mechanisms of pharmacogenomic effects of genetic variation within the cardiac adrenergic network in heart failure.
- Targeted transgenesis reveals discrete attenuator functions of GRK and PKA in airway beta2-adrenergic receptor physiologic signaling.
- An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity.
- Sequencing and analyses of all known human rhinovirus genomes reveal structure and evolution.
- Bitransgenesis with beta(2)-adrenergic receptors or adenylyl cyclase fails to improve beta(1)-adrenergic receptor cardiomyopathy.
- Pharmacogenomics of beta-adrenergic receptors and their accessory signaling proteins in heart failure.
- ARG1 is a novel bronchodilator response gene: screening and replication in four asthma cohorts.
- Differential coupling of Arg- and Gly389 polymorphic forms of the beta1-adrenergic receptor leads to pathogenic cardiac gene regulatory programs.
- Lack of association between adrenergic receptor genotypes and survival in heart failure patients treated with carvedilol or metoprolol.
- A polymorphism of G-protein coupled receptor kinase5 alters agonist-promoted desensitization of beta2-adrenergic receptors.
- A GRK5 polymorphism that inhibits beta-adrenergic receptor signaling is protective in heart failure.
- Alternative splicing of the G protein-coupled receptor superfamily in human airway smooth muscle diversifies the complement of receptors.
- Variable-length poly-C tract polymorphisms of the beta2-adrenergic receptor 3'-UTR alter expression and agonist regulation.
- Genetic variation within the beta1-adrenergic receptor gene results in haplotype-specific expression phenotypes.
- Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis.
- Heterogeneity of transcription factor expression and regulation in human airway epithelial and smooth muscle cells.
- Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity.
- Allele-specific binding of airway nuclear extracts to polymorphic beta2-adrenergic receptor 5' sequence.
- Crosstalk between Gi and Gq/Gs pathways in airway smooth muscle regulates bronchial contractility and relaxation.
- Long-distance affair with adrenal GRK2 hangs up heart failure.
- Pleiotropic beta-agonist-promoted receptor conformations and signals independent of intrinsic activity.
- Sequence, haplotype, and association analysis of ADRbeta2 in a multiethnic asthma case-control study.
- Transcriptional response to persistent beta2-adrenergic receptor signaling reveals regulation of phospholamban, which alters airway contractility.
- A polymorphism within a conserved beta(1)-adrenergic receptor motif alters cardiac function and beta-blocker response in human heart failure.
- Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex.
- Alpha2A- and alpha2C-adrenergic receptors form homo- and heterodimers: the heterodimeric state impairs agonist-promoted GRK phosphorylation and beta-arrestin recruitment.
- Beta2-adrenergic receptor polymorphisms and sudden cardiac death: a signal to follow.
- Complex haplotypes derived from noncoding polymorphisms of the intronless alpha2A-adrenergic gene diversify receptor expression.
- Myocardial beta1-adrenergic receptor polymorphisms affect functional recovery after ischemic injury.
- Cardiac 7-transmembrane-spanning domain receptor portfolios: diversify, diversify, diversify.
- The presence of Lys27 instead of Asn27 in human phospholamban promotes sarcoplasmic reticulum Ca2+-ATPase superinhibition and cardiac remodeling.
- Molecular mechanisms of beta2-adrenergic receptor function and regulation.
- Polymorphisms of beta-adrenergic receptors in heart failure.
- A primate-dominant third glycosylation site of the beta2-adrenergic receptor routes receptors to degradation during agonist regulation.
- Polymorphisms of cardiac presynaptic alpha2C adrenergic receptors: Diverse intragenic variability with haplotype-specific functional effects.
- The two-timing thyroid.
- PKC-alpha regulates cardiac contractility and propensity toward heart failure.
- Common genomic response in different mouse models of beta-adrenergic-induced cardiomyopathy.
- Protein kinase Calpha negatively regulates systolic and diastolic function in pathological hypertrophy.
- Activity of the uptake-1 norepinephrine transporter as measured by I-123 MIBG in heart failure patients with a loss-of-function polymorphism of the presynaptic alpha2C...
- Beta 1-adrenergic receptor polymorphisms confer differential function and predisposition to heart failure.
- Antithetic regulation by beta-adrenergic receptors of Gq receptor signaling via phospholipase C underlies the airway beta-agonist paradox.
- Polymorphisms of adrenergic receptors: variations on a theme.
- Hierarchy of polymorphic variation and desensitization permutations relative to beta 1- and beta 2-adrenergic receptor signaling.
- Human phospholamban null results in lethal dilated cardiomyopathy revealing a critical difference between mouse and human.
- Pharmacology and physiology of human adrenergic receptor polymorphisms.
- Yohimbine dimers exhibiting selectivity for the human alpha 2C-adrenoceptor subtype.
- Update on current concepts of the molecular basis of beta2-adrenergic receptor signaling.
- Polymorphisms of the beta1-adrenergic receptor predict exercise capacity in heart failure.
- Synergistic polymorphisms of beta1- and alpha2C-adrenergic receptors and the risk of congestive heart failure.
- Polymorphisms of the beta2-adrenergic receptor.
- Amino acid 49 polymorphisms of the human beta1-adrenergic receptor affect agonist-promoted trafficking.
- Identification of adrenergic receptor polymorphisms.
- Genome sequences of rhinovirus a isolates from wisconsin pediatric respiratory studies.
- Genome sequences of rhinovirus B isolates from wisconsin pediatric respiratory studies.
- Genome sequences of rhinovirus C isolates from wisconsin pediatric respiratory studies.
Schools
University of Miami School of Medicine
Doctors Specialties
- Pulmonology
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
- Whos Who in Medicine and Healthcare
Education
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Washington University -
Washington University - Barnes-Jewish Hospital -
University of Miami Miller School of Medicine
Hospital
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University of Maryland Medical Center
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