Associate Professor, Pediatrics, Pennsylvania State University College of Medicine

Pediatric Hematology & Oncology

Sinisa Dovat practices Pediatric Hematology & Oncology. Sinisa Dovat is also published. He has 36 publications published. The lastest publication: "Isolation, cloning, and characterization of a novel rat lung zinc finger gene, RLZF-Y.'

Publications

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• Protein signaling and regulation of gene transcription in Leukemia: role of the Casein Kinase II-Ikaros axis.
• Transcriptional Regulation of JARID1B/KDM5B Histone Demethylase by Ikaros, Histone Deacetylase 1 (HDAC1), and Casein Kinase 2 (CK2) in B-cell Acute Lymphoblastic Leuke...
• Clinical significance of high c-MYC and low MYCBP2 expression and their association with Ikaros dysfunction in adult Acute lymphoblastic leukemia.
• Targeting casein kinase II restores Ikaros tumor suppressor activity and demonstrates therapeutic efficacy in high-risk Leukemia.
• Protein Phosphatase 1 (PP1) and Casein Kinase II (CK2) regulate Ikaros-mediated repression of TdT in thymocytes and T-cell Leukemia.
• G0S2-A new player in Leukemia.
• Ikaros: the enhancer makes the difference.
• Genetic targets in pediatric Acute lymphoblastic leukemia.
• Cell cycle-specific function of Ikaros in human Leukemia.
• Unrelated umbilical cord stem Cell transplantation for X-linked immunodeficiencies.
• Immune thrombocytopenia after umbilical cord progenitor cell transplant: response to vincristine.
• Isolation, cloning, and characterization of a novel rat Lung zinc finger gene, RLZF-Y.
• Targeted identification of zinc finger genes expressed in rat Lungs.
• The use of umbilical cord blood stem Cells for hematopoietic reconstitution.
• [Hematologic parameter of red blood Cells in children up to 2 years of age].
• [Supplementary feeding--additional food in daily infant nutrition].
• A transcriptionally permissive epigenetic landscape at the vasoactive intestinal peptide receptor-1 promoter suggests a euchromatin nuclear position in murine CD4 T ce...
• Ikaros is expressed in human extravillous trophoblasts and involved in their migration and invasion.
• Transgenic expression of Helios in B lineage cells alters B cell properties and promotes Lymphomagenesis.
• A common mechanism for mitotic inactivation of C2H2 zinc finger DNA-binding domains.
• Ikaros and tumor suppression in Acute lymphoblastic leukemia.
• Pre-B Cell receptor-mediated activation of BCL6 induces pre-B Cell quiescence through transcriptional repression of MYC.
• Ikaros isoforms: The saga continues.
• Regulation of Ikaros function by casein kinase 2 and protein phosphatase 1.
• Ikaros in hematopoiesis and Leukemia.
• Ikaros, CK2 kinase, and the road to Leukemia.
• Congenital Pancytopenia and absence of B lymphocytes in a neonate with a mutation in the ikaros gene.
• AMID mediates adenosine-induced caspase-independent HuH-7 Cell apoptosis.
• Tumor suppression in T cell Leukemia--the role of Ikaros.
• IL-7 Dependence in human B lymphopoiesis increases during progression of ontogeny from cord blood to bone marrow.
• Ikaros stability and pericentromeric localization are regulated by protein phosphatase 1.
• Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing.
• Severe congenital protein C deficiency: description of a new mutation and prophylactic protein C therapy and in vivo pharmacokinetics.
• Recruitment of ikaros to pericentromeric heterochromatin is regulated by phosphorylation.
• Human Ikaros function in activated T Cells is regulated by coordinated expression of its largest isoforms.

Schools

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• University Of Novi Sad Faculty Of Medicine

• Penn St University Hp M S Hershey Mc

• UCLA Med CtrUCLA D Geffen School

Procedures Preformed

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• HPC Transplantation (Stem Cell Transplant)
• Plasmapheresis

Conditions Treated

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• Acute Leukemia
• Adrenal Gland Cancer
• Anemia
• Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
• View All

Doctors Specialties

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• Pediatric Hematology
• Oncology

Accepted Insurances

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• Aetna
• Amerihealth
• Blue Card PPO
• Capital Blue Cross
• Cigna PPO
• Great West Healthcare-Cigna PPO
• Open Access Plus
• Commercial Insurance Company
• Coventry Health Care
• First Health (Coventry Health Care) PPO
• Community Blue PPO
• Medicaid
• Medicare MCR
• PHCS Network PPO
• Tricare
• Choice Plus POS
• Navigate HMO
• Navigate POS
• Options PPO
• United Healthcare

Education

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• UCLA Medical Center
• Penn State University
• University of Novi Sad Faculty of Medicine

Hospital

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• University of Wisconsin Hospital and Clinics
• Penn State Milton S. Hershey Medical Center

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