Physician
Internal Medicine
Dr. Robert S. Adelstein, MD
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Doctor Robert S. Adelstein, MD practices Internal Medicine. He graduated from Harvard Medical School. Harvard Medical School is a top medical university. Harvard Medical School has a rank of 1 in research and a 12 in primary care He has 1 awards "Elected Member". Robert Adelstein has written publications. He has 80 publications published with PubMed. The lastest publication is: 'Nonmuscle myosin II-B is required for normal development of the mouse heart.'
Publications
- Myosin II controls cellular branching morphogenesis and migration in three dimensions by minimizing cell-surface curvature.
- Rbfox3 controls the biogenesis of a subset of microRNAs.
- Isoform-specific proteasomal degradation of Rbfox3 during chicken embryonic development.
- Folliculin (Flcn) inactivation leads to murine cardiac hypertrophy through mTORC1 deregulation.
- Nonmuscle Myosin II is a Critical Regulator of Clathrin Mediated Endocytosis.
- Keratin 5-Cre-driven excision of nonmuscle myosin IIA in early embryo trophectoderm leads to placenta defects and embryonic lethality.
- NMII Forms a Contractile Transcellular Sarcomeric Network to Regulate Apical Cell Junctions and Tissue Geometry.
- Nonmuscle Myosin IIB Links Cytoskeleton to IRE1ñ Signaling during ER Stress.
- Non-muscle myosin IIB is essential for cytokinesis during male meiotic cell divisions.
- Nonmuscle Myosin II Is Required for Internalization of the Epidermal Growth Factor Receptor and Modulation of Downstream Signaling.
- Micro-environmental control of cell migration--myosin IIA is required for efficient migration in fibrillar environments through control of cell adhesion dynamics.
- Nonmuscle myosin II exerts tension but does not translocate actin in vertebrate cytokinesis.
- Mouse models of MYH9-related disease: mutations in nonmuscle myosin II-A.
- In vivo studies on nonmuscle myosin II expression and function in heart development.
- LPA(1) -induced migration requires nonmuscle myosin II light chain phosphorylation in breast cancer cells.
- Distinct and redundant roles of the non-muscle myosin II isoforms and functional domains.
- Fox-3 and PSF interact to activate neural cell-specific alternative splicing.
- Ablation of nonmuscle myosin II-B and II-C reveals a role for nonmuscle myosin II in cardiac myocyte karyokinesis.
- Confinement-optimized three-dimensional T cell amoeboid motility is modulated via myosin IIA-regulated adhesions.
- Non-muscle myosin II regulates survival threshold of pluripotent stem cells.
- Nonmuscle myosin II isoform and domain specificity during early mouse development.
- Conditional ablation of nonmuscle myosin II-B delineates heart defects in adult mice.
- Identification of neuronal nuclei (NeuN) as Fox-3, a new member of the Fox-1 gene family of splicing factors.
- Non-muscle myosin II takes centre stage in cell adhesion and migration.
- Myosin II regulates extension, growth and patterning in the mammalian cochlear duct.
- An alternatively spliced isoform of non-muscle myosin II-C is not regulated by myosin light chain phosphorylation.
- Local cortical tension by myosin II guides 3D endothelial cell branching.
- Non-muscle myosin IIA differentially regulates intestinal epithelial cell restitution and matrix invasion.
- The B2 alternatively spliced isoform of nonmuscle myosin II-B lacks actin-activated MgATPase activity and in vitro motility.
- Nonmuscle myosin II moves in new directions.
- A unique role for nonmuscle myosin heavy chain IIA in regulation of epithelial apical junctions.
- Replacement of nonmuscle myosin II-B with II-A rescues brain but not cardiac defects in mice.
- Loss of cell adhesion causes hydrocephalus in nonmuscle myosin II-B-ablated and mutated mice.
- Myosin IIA regulates cell motility and actomyosin-microtubule crosstalk.
- A specific isoform of nonmuscle myosin II-C is required for cytokinesis in a tumor cell line.
- A novel guanine nucleotide exchange factor MyoGEF is required for cytokinesis.
- Function of the neuron-specific alternatively spliced isoforms of nonmuscle myosin II-B during mouse brain development.
- Disease-associated mutations and alternative splicing alter the enzymatic and motile activity of nonmuscle myosins II-B and II-C.
- Vertebrate nonmuscle myosin II isoforms rescue small interfering RNA-induced defects in COS-7 cell cytokinesis.
- Basic mechanism of three-dimensional collagen fibre transport by fibroblasts.
- Defects in cell adhesion and the visceral endoderm following ablation of nonmuscle myosin heavy chain II-A in mice.
- A point mutation in the motor domain of nonmuscle myosin II-B impairs migration of distinct groups of neurons.
- Nonmuscle myosin IIb is involved in the guidance of fibroblast migration.
- Identification and characterization of nonmuscle myosin II-C, a new member of the myosin II family.
- Menin, a tumor suppressor, associates with nonmuscle myosin II-A heavy chain.
- Ablation and mutation of nonmuscle myosin heavy chain II-B results in a defect in cardiac myocyte cytokinesis.
- Induction of nonmuscle myosin heavy chain II-C by butyrate in RAW 264.7 mouse macrophages.
- Pitx2a expression alters actin-myosin cytoskeleton and migration of HeLa cells through Rho GTPase signaling.
- Myosin IIB is required for growth cone motility.
- A Rho-dependent signaling pathway operating through myosin localizes beta-actin mRNA in fibroblasts.
- Structural abnormalities develop in the brain after ablation of the gene encoding nonmuscle myosin II-B heavy chain.
- Calcium-dependent threonine phosphorylation of nonmuscle myosin in stimulated RBL-2H3 mast cells.
- Conditional expression of a truncated fragment of nonmuscle myosin II-A alters cell shape but not cytokinesis in HeLa cells.
- Nonmuscle myosin II localizes to the Z-lines and intercalated discs of cardiac muscle and to the Z-lines of skeletal muscle.
- Gene dosage affects the cardiac and brain phenotype in nonmuscle myosin II-B-depleted mice.
- Nonmuscle myosin II-B is required for normal development of the mouse heart.
- Xenopus nonmuscle myosin heavy chain isoforms have different subcellular localizations and enzymatic activities.
- Identification of the chimeric protein product of the CBFB-MYH11 fusion gene in inv(16) leukemia cells.
- Baculovirus expression of chicken nonmuscle heavy meromyosin II-B. Characterization of alternatively spliced isoforms.
- Cloning of the cDNA encoding rat myosin heavy chain-A and evidence for the absence of myosin heavy chain-B in cultured rat mast (RBL-2H3) cells.
- Localization of myosin II A and B isoforms in cultured neurons.
- Cloning of the cDNA encoding human nonmuscle myosin heavy chain-B and analysis of human tissues with isoform-specific antibodies.
- Neuronal cell expression of inserted isoforms of vertebrate nonmuscle myosin heavy chain II-B.
- Characterization of myosin II isoforms containing insertions of amino acids in the flexible loop near the ATP-binding pocket.
- A Xenopus nonmuscle myosin heavy chain isoform is phosphorylated by cyclin-p34cdc2 kinase during meiosis.
- Characterization of isoform diversity in smooth muscle myosin heavy chains.
- Secretion from rat basophilic RBL-2H3 cells is associated with diphosphorylation of myosin light chains by myosin light chain kinase as well as phosphorylation by prot...
- An insert of seven amino acids confers functional differences between smooth muscle myosins from the intestines and vasculature.
- Evidence for inserted sequences in the head region of nonmuscle myosin specific to the nervous system. Cloning of the cDNA encoding the myosin heavy chain-B isoform of...
- Differential expression of SM1 and SM2 myosin isoforms in cultured vascular smooth muscle.
- Smooth muscle myosin is composed of homodimeric heavy chains.
- Chicken nonmuscle myosin heavy chains: differential expression of two mRNAs and evidence for two different polypeptides.
- Identification of the serine residue phosphorylated by protein kinase C in vertebrate nonmuscle myosin heavy chains.
- The 204-kDa smooth muscle myosin heavy chain is phosphorylated in intact cells by casein kinase II on a serine near the carboxyl terminus.
- Substance P contracts bovine tracheal smooth muscle via activation of myosin light chain kinase.
- Antigen-induced secretion of histamine and the phosphorylation of myosin by protein kinase C in rat basophilic leukemia cells.
- In situ phosphorylation of human platelet myosin heavy and light chains by protein kinase C.
- Regulation of actin microfilament integrity in living nonmuscle cells by the cAMP-dependent protein kinase and the myosin light chain kinase.
- The heavy chain of smooth muscle myosin is phosphorylated in aorta cells.
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
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Duke University Hospital -
NYU School of Medicine -
Harvard Medical School
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