William and Elizabeth Sweet Professor of Neuroscience in the Department of Surgery, Mass Gen Hosp
Neurosurgery
Dr. Robert L. Martuza, MD
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Robert L. Martuza, MD practices Neurosurgery. He researched medicine at Harvard Medical School. Harvard Medical School is one of the top medical schools in the US. Harvard Medical School has a rank of 1 in research and a 12 in primary care He over the years received 7 awards: "America's Top Doctors", "Boston Magazine", "America's Top Doctors for Cancer", "Elected Member", "Boston Herald", "Fellow (FAANS)" and "Super Doctor". Robert Martuza is a published doctor as well. He has 50 publications published. The latest was: A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus. Robert Martuza accepts all Medicare patients.
Publications
- Benign Meningiomas (WHO Grade I) with atypical histological features: correlation of histopathological features with clinical outcomes.
- Single agent efficacy of the VEGFR kinase inhibitor axitinib in preclinical models of glioblastoma.
- Single-cell RNA-seq highlights intratumoral heterogeneity in primary glioblastoma.
- Reconstructing and Reprogramming the Tumor-Propagating Potential of Glioblastoma Stem-like Cells.
- Treatment of orthotopic malignant peripheral Nerve sheath tumors with oncolytic herpes simplex virus.
- Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent Cancer stem cell model.
- An Aberrant Transcription Factor Network Essential for Wnt Signaling and Stem Cell Maintenance in Glioblastoma.
- Combination of vinblastine and oncolytic herpes simplex virus vector expressing IL-12 therapy increases antitumor and antiangiogenic effects in prostate Cancer models.
- Anesthesia for suboccipital craniotomy in a patient with lymphangioleiomyomatosis: a case report.
- Multimechanistic Tumor Targeted Oncolytic Virus Overcomes Resistance in Brain Tumors.
- Expression of FMS-like Tyrosine Kinase 3 Ligand by Oncolytic Herpes Simplex Virus Type I Prolongs Survival in Mice Bearing Established Syngeneic Intracranial Malignant...
- Oncolytic herpes simplex virus counteracts the hypoxia-induced modulation of glioblastoma stem-like cells.
- Oncolytic Virus-Mediated Manipulation of DNA Damage Responses: Synergy With Chemotherapy in Killing Glioblastoma Stem Cells.
- Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells.
- Enhanced anti-tumor efficacy of low dose etoposide with oncolytic herpes simplex virus in human glioblastoma stem cell xenografts.
- Bevacizumab With Angiostatin-armed oHSV Increases Antiangiogenesis and Decreases Bevacizumab-induced Invasion in U87 Glioma.
- Distinguishing inflammation from tumor and peritumoral edema by myeloperoxidase magnetic resonance imaging.
- A Novel Oncolytic Herpes Simplex Virus that Synergizes with Phosphatidylinositol 3-Kinase/Akt Pathway Inhibitors to Target Glioblastoma Stem Cells.
- Identification of diagnostic serum protein profiles of glioblastoma patients.
- Identification of the ENT1 antagonists dipyridamole and dilazep as amplifiers of oncolytic herpes simplex virus-1 replication.
- Genetic determinants of hearing loss associated with vestibular Schwannomas.
- Human glioblastoma-derived Cancer stem cells: establishment of invasive glioma models and treatment with oncolytic herpes simplex virus vectors.
- Assessment of therapeutic efficacy and fate of engineered human mesenchymal stem cells for Cancer therapy.
- Hypoxia enhances the replication of oncolytic herpes simplex virus.
- Long-term recurrence rates of atypical Meningiomas after gross total resection with or without postoperative adjuvant radiation.
- Ras signaling influences permissiveness of malignant peripheral Nerve sheath tumor cells to oncolytic herpes.
- Combination immunotherapy for Tumors via sequential intratumoral injections of oncolytic herpes simplex virus 1 and immature dendritic cells.
- Trichostatin A and oncolytic HSV combination therapy shows enhanced antitumoral and antiangiogenic effects.
- Systemic therapy of spontaneous prostate cancer in transgenic mice with oncolytic herpes simplex viruses.
- Depletion of peripheral macrophages and Brain microglia increases Brain tumor titers of oncolytic viruses.
- Herpes simplex virus Us3(-) mutant as oncolytic strategy and synergizes with phosphatidylinositol 3-kinase-Akt targeting molecular therapeutics.
- Angiogenic response caused by oncolytic herpes simplex virus-induced reduced thrombospondin expression can be prevented by specific viral mutations or by administering...
- Oncolytic herpes simplex virus therapy for peripheral Nerve tumors.
- Oncolytic HSV armed with platelet factor 4, an antiangiogenic agent, shows enhanced efficacy.
- Dominant-negative fibroblast growth factor receptor expression enhances antitumoral potency of oncolytic herpes simplex virus in neural Tumors.
- Effective treatment of Tumors with strong beta-catenin/T-cell factor activity by transcriptionally targeted oncolytic herpes simplex virus vector.
- Vestibular Schwannoma.
- Systemic oncolytic herpes virus therapy of poorly immunogenic prostate cancer metastatic to lung.
- Effect of chemotherapy-induced DNA repair on oncolytic herpes simplex viral replication.
- Oncolytic herpes simplex virus mutants exhibit enhanced replication in glioma cells evading temozolomide chemotherapy through deoxyribonucleic acid repair.
- Triple gene-deleted oncolytic herpes simplex virus vector double-armed with interleukin 18 and soluble B7-1 constructed by bacterial artificial chromosome-mediated sys...
- Oncolytic herpes simplex virus vector g47delta in combination with androgen ablation for the treatment of human prostate adenocarcinoma.
- Stereotactic radiotherapy for vestibular Schwannomas: favorable outcome with minimal toxicity.
- Circulating growth factor levels are associated with tumorigenesis in neurofibromatosis type 1.
- Somatic mitochondrial DNA mutations in neurofibromatosis type 1-associated Tumors.
- Proton beam radiosurgery for vestibular Schwannoma: tumor control and cranial nerve toxicity.
- CT changes of an intracranial granulocytic sarcoma on short-term follow-up.
- Antiangiogenesis in neurofibromatosis 1.
- A new patient-derived orthotopic malignant meningioma model treated with oncolytic herpes simplex virus.
Schools
Harvard Medical School
Massachusetts General Hospital
Procedures Preformed
- Craniectomy, Craniotomy, Surgery of Skull Base, Neuroendoscopy
- Lamina Procedures (incl. Laminectomy, Laminoplasty, Laminotomy)
Conditions Treated
- Acoustic Neuroma
- Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
- Brain Cancer
- Epilepsy
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Doctors Specialties
- Neurosurgery
Accepted Insurances
Awards
- America's Top Doctors
- Boston Magazine
- America's Top Doctors for Cancer
- Elected Member
- Boston Herald
- Fellow (FAANS)
- Super Doctor
Education
-
Massachusetts General Hospital -
Harvard Medical School
Hospital
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Massachusetts General Hospital
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1861482135 |
| Last Name Of The Provider | MARTUZA |
| First Name Of The Provider | ROBERT |
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