Physician
Psychiatry
Dr. Robert B. Innis, MD
Doctor Robert B. Innis, MD is an expert in the field of Psychiatry. Robert B. Innis, MD is a published MD as well. He has 98 publications published. The latest was: Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein.
Publications
- Tariquidar Is an Inhibitor and Not a Substrate of Human and Mouse P-glycoprotein.
- The PET Radioligand 18F-FIMX Images and Quantifies Metabotropic Glutamate Receptor 1 in Proportion to the Regional Density of Its Gene Transcript in Human Brain.
- Increased permeability-glycoprotein inhibition at the human blood-brain barrier can be safely achieved by performing PET during peak plasma concentrations of tariquidar.
- Application of calibrated image-derived input function to a clinical protocol.
- Synthesis and Evaluation of Translocator 18 kDa Protein (TSPO) Positron Emission Tomography (PET) Radioligands with Low Binding Sensitivity to Human Single Nucleotide ...
- Development of N-Methyl-(2-arylquinolin-4-yl)oxypropanamides as Leads to PET Radioligands for Translocator Protein (18 kDa).
- Synthesis and evaluation of candidate PET radioligands for corticotropin-releasing factor type-1 receptors.
- 11C-CUMI-101, a PET Radioligand, Behaves as a Serotonin 1A Receptor Antagonist and Also Binds to α1 Adrenoceptors in Brain.
- Retest imaging of [(11)C]NOP-1A binding to nociceptin/orphanin FQ peptide (NOP) receptors in the brain of healthy humans.
- Antidepressant effects on serotonin 1A/1B receptors in the rat brain using a Gene x Environment model.
- Synthesis and Evaluation in Monkey of [(18)F]4-Fluoro-N-methyl-N-(4-(6-(methylamino)pyrimidin-4-yl)thiazol-2-yl)benzamide ([(18)F]FIMX): A Promising Radioligand for PE...
- In vitro and in vivo evaluation of (11)C-SD5024, a novel PET radioligand for human brain imaging of cannabinoid CB1 receptors.
- Reduced cannabinoid CB1 receptor binding in alcohol dependence measured with positron emission tomography.
- Suggested pathway to assess radiation safety of (18)F-labeled PET tracers for first-in-human studies.
- In vivo radioligand binding to translocator protein correlates with severity of Alzheimer's disease.
- Factors That Limit Positron Emission Tomography Imaging of P-Glycoprotein Density at the Blood-Brain Barrier.
- A genetic polymorphism for translocator protein 18 kDa affects both in vitro and in vivo radioligand binding in human brain to this putative biomarker of neuroinflamma...
- Evaluation in vitro and in animals of a new 11C-labeled PET radioligand for metabotropic glutamate receptors 1 in brain.
- Propofol Decreases In Vivo Binding of 11C-PBR28 to Translocator Protein (18 kDa) in the Human Brain.
- ¹¹CRhodamine-123: synthesis and biodistribution in rodents.
- Binding of a tritiated inverse agonist to cannabinoid CB1 receptors is increased in patients with schizophrenia.
- Peripheral Cannabinoid-1 Receptor Inverse Agonism Reduces Obesity by Reversing Leptin Resistance.
- Image-derived input function in PET brain studies: blood-based methods are resistant to motion artifacts.
- Downregulation of Brain Phosphodiesterase Type IV Measured with (11)C-(R)-Rolipram Positron Emission Tomography in Major Depressive Disorder.
- Reversible and regionally selective downregulation of brain cannabinoid CB1 receptors in chronic daily cannabis smokers.
- Increased In Vivo Expression of an Inflammatory Marker in Temporal Lobe Epilepsy.
- On quantitative relationships between drug-like compound lipophilicity and plasma free fraction in monkey and human.
- Suggested pathway to assess radiation safety of (11)C-labeled PET tracers for first-in-human studies.
- Serotonin-1A receptors in major depression quantified using PET: Controversies, confounds, and recommendations.
- Quantification of metabotropic glutamate subtype 5 receptors in the brain by an equilibrium method using (18)F-SP203.
- Brain and Whole-Body Imaging in Rhesus Monkeys of 11C-NOP-1A, a Promising PET Radioligand for Nociceptin/Orphanin FQ Peptide Receptors.
- Image-derived input function for brain PET studies: many challenges and few opportunities.
- Occupancy of dopamine D(2) and D (3) and serotonin 5-HT (1A) receptors by the novel antipsychotic drug candidate, cariprazine (RGH-188), in monkey brain measured using...
- Synthesis and Evaluation of Radioligands for Imaging Brain Nociceptin/Orphanin FQ Peptide (NOP) Receptors with Positron Emission Tomography.
- Erratum to: Translocator Protein PET Imaging for Glial Activation in Multiple Sclerosis.
- Lysosomal trapping of a radiolabeled substrate of P-glycoprotein as a mechanism for signal amplification in PET.
- Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-deri...
- Mixed-affinity binding in humans with 18-kDa translocator protein ligands.
- Human Biodistribution and Dosimetry of C-CUMI-101, an Agonist Radioligand for Serotonin-1A Receptors in Brain.
- Image-derived input function for human brain using high resolution PET imaging with [C](R)-rolipram and [C]PBR28.
- Evaluation of Novel N(1)-Methyl-2-phenylindol-3-ylglyoxylamides as a New Chemotype of 18 kDa Translocator Protein-Selective Ligand Suitable for the Development of Posi...
- Translocator protein PET imaging for glial activation in multiple sclerosis.
- Dopamine beta-hydroxylase-deficient mice have normal densities of D(2) dopamine receptors in the high-affinity state based on in vivo PET imaging and in vitro radiolig...
- In vivo binding of protoporphyrin IX to rat translocator protein imaged with positron emission tomography.
- [carbonyl-C]Benzyl acetate: automated radiosynthesis via Pd-mediated [C]carbon monoxide chemistry and PET measurement of brain uptake in monkey.
- N-desmethyl-loperamide is selective for P-glycoprotein among three ATP-binding cassette transporters at the blood-brain barrier.
- D2 dopamine receptor internalization prolongs the decrease of radioligand binding after amphetamine: a PET study in a receptor internalization-deficient mouse model.
- P-glycoprotein function at the blood-brain barrier in humans can be quantified with the substrate radiotracer 11C-N-desmethyl-loperamide.
- Comparison of [(11)C]-(R)-PK 11195 and [(11)C]PBR28, two radioligands for translocator protein (18 kDa) in human and monkey: Implications for positron emission tomogra...
- Effects of cAMP-dependent protein kinase activator and inhibitor on in vivo rolipram binding to phosphodiesterase 4 in conscious rats.
- Imaging and quantitation of cannabinoid CB1 receptors in human and monkey brains using (18)F-labeled inverse agonist radioligands.
- Evaluation of [C]S14506 and [F]S14506 in rat and monkey as agonist PET radioligands for brain 5-HT(1A) receptors.
- Biodistribution and radiation dosimetry in humans of a new PET ligand, (18)F-PBR06, to image translocator protein (18 kDa).
- Quantitation of cannabinoid CB1 receptors in healthy human brain using positron emission tomography and an inverse agonist radioligand.
- Stroke incidentally identified using improved positron emission tomography for microglial activation.
- Quantification of translocator protein (18 kDa) in the human brain with PET and a novel radioligand, (18)F-PBR06.
- Decreased neurokinin-1 (substance P) receptor binding in patients with panic disorder: positron emission tomographic study with [18F]SPA-RQ.
- Arrestin3 mediates D(2) dopamine receptor internalization.
- Pharmacological characterization of 2-methoxy-N-propylnorapomorphine's interactions with D2 and D3 dopamine receptors.
- Human brain imaging and radiation dosimetry of 11C-N-desmethyl-loperamide, a PET radiotracer to measure the function of P-glycoprotein.
- PET measurement of the in vivo affinity of 11C-(R)-rolipram and the density of its target, phosphodiesterase-4, in the brains of conscious and anesthetized rats.
- Single-step high-yield radiosynthesis and evaluation of a sensitive 18F-labeled ligand for imaging brain peripheral benzodiazepine receptors with PET.
- Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system.
- P-glycoprotein function at the blood-brain barrier imaged using 11C-N-desmethyl-loperamide in monkeys.
- Evaluation of [11C]PipISB and [18F]PipISB in monkey as candidate radioligands for imaging brain cannabinoid type-1 receptors in vivo.
- Investigation of the metabolites of (S,S)-[(11)C]MeNER in humans, monkeys and rats.
- Metabotropic glutamate subtype 5 receptors are quantified in the human brain with a novel radioligand for PET.
- Radiodefluorination of 3-fluoro-5-(2-(2-[18F](fluoromethyl)-thiazol-4-yl)ethynyl)benzonitrile ([18F]SP203), a radioligand for imaging brain metabotropic glutamate subt...
- Synthesis and evaluation of [N-methyl-11C]N-desmethyl-loperamide as a new and improved PET radiotracer for imaging P-gp function.
- Occupancy of dopamine D2/3 receptors in rat brain by endogenous dopamine measured with the agonist positron emission tomography radioligand [11C]MNPA.
- Kinetic brain analysis and whole-body imaging in monkey of [11C]MNPA: a dopamine agonist radioligand.
- Striatal dopamine transporters correlate with simple reaction time in elderly subjects.
- Positron emission tomography imaging using an inverse agonist radioligand to assess cannabinoid CB1 receptors in rodents.
- Small effect of dopamine release and no effect of dopamine depletion on [18F]fallypride binding in healthy humans.
- It is time to take a stand for medical research and against terrorism targeting medical scientists.
- 11C-loperamide and its N-desmethyl radiometabolite are avid substrates for brain permeability-glycoprotein efflux.
- Kinetic analysis in healthy humans of a novel positron emission tomography radioligand to image the peripheral benzodiazepine receptor, a potential biomarker for infla...
- Brain and whole-body imaging in nonhuman primates of [11C]PBR28, a promising PET radioligand for peripheral benzodiazepine receptors.
- Synthesis and evaluation in monkey of two sensitive 11C-labeled aryloxyanilide ligands for imaging brain peripheral benzodiazepine receptors in vivo.
- Synthesis and evaluation of N-methyl and S-methyl 11C-labeled 6-methylthio-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridines as radioligands for imaging beta-amylo...
- The PET radioligand [11C]MePPEP binds reversibly and with high specific signal to cannabinoid CB1 receptors in nonhuman primate brain.
- Radiation dosimetry and biodistribution in monkey and man of 11C-PBR28: a PET radioligand to image inflammation.
- Synthesis and structure-affinity relationships of new 4-(6-iodo-H-imidazo[1,2-a]pyridin-2-yl)-N-dimethylbenzeneamine derivatives as ligands for human beta-amyloid plaq...
- Consensus nomenclature for in vivo imaging of reversibly binding radioligands.
- Kinetic evaluation in nonhuman primates of two new PET ligands for peripheral benzodiazepine receptors in brain.
- Synthesis and simple 18F-labeling of 3-fluoro-5-(2-(2-(fluoromethyl)thiazol-4-yl)ethynyl)benzonitrile as a high affinity radioligand for imaging monkey brain metabotro...
- Quantification of serotonin 5-HT1A receptors in humans with [11C](R)-(-)-RWAY: radiometabolite(s) likely confound brain measurements.
- Disulfiram inhibits defluorination of (18)F-FCWAY, reduces bone radioactivity, and enhances visualization of radioligand binding to serotonin 5-HT1A receptors in human...
- Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease.
- PET imaging of neurokinin-1 receptors with [(18)F]SPA-RQ in human subjects: assessment of reference tissue models and their test-retest reproducibility.
- In vivo and in vitro measurement of brain phosphodiesterase 4 in rats after antidepressant administration.
- Effect of a P-glycoprotein inhibitor, Cyclosporin A, on the disposition in rodent brain and blood of the 5-HT1A receptor radioligand, [11C](R)-(-)-RWAY.
- Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar im...
- Quantification of serotonin 5-HT1A receptors in monkey brain with [11C](R)-(-)-RWAY.
- Molecular imaging of the dopaminergic system and its association with human cognitive function.
- Imaging and in vivo quantitation of beta-amyloid: an exemplary biomarker for Alzheimer's disease?
- Effects of early life stress on [11C]DASB positron emission tomography imaging of serotonin transporters in adolescent peer- and mother-reared rhesus monkeys.
Schools
Johns Hopkins University School of Medicine
Doctors Specialties
- Psychiatry
Accepted Insurances
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