Professor, Molecular Medicine, Case Western Reserve University School of Medicine
Neurology
Dr. Richard M. Ransohoff, MD
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Dr. Richard M. Ransohoff practices Neurology. He researched medicine at Case Western Reserve University School of Medicine. He has 1 awards "CMS Meaningful Use Stage 1 Certification". Richard M. Ransohoff is also published. He has 101 publications published. The lastest publication: "T cell-intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis.' Doctor Richard M. Ransohoff, MD accepts all Medicare patients.
Publications
- Neutrophil depletion after subarachnoid hemorrhage improves memory via NMDA receptors.
- Identification of a unique molecular and functional microglia signature in health and disease.
- A destructive feedBack loop mediated by CXCL10 in CNS inflammatory disease.
- Multiple sclerosis-a quiet revolution.
- TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models.
- Physiology. Good barriers make good neighbors.
- A meditation on medications, among other things.
- Opposing Effects of Membrane-Anchored CX3CL1 on Amyloid and Tau Pathologies via the p38 MAPK Pathway.
- Ontogeny and Functions of Central Nervous System Macrophages.
- Rapid Remodeling of Tight Junctions during Paracellular Diapedesis in a Human Model of the Blood-Brain Barrier.
- Mitochondrial immobilization mediated by syntaphilin facilitates survival of demyelinated axons.
- Systemic Lipopolysaccharide Induces Cochlear Inflammation and Exacerbates the Synergistic Ototoxicity of Kanamycin and Furosemide.
- Inhibition of CXCR7 extends survival following irradiation of brain tumours in mice and rats.
- High-resolution intravital imaging reveals that blood-derived macrophages but not resident microglia facilitate secondary axonal dieBack in traumatic spinal cord injury.
- Identification of a unique TGF-β-dependent molecular and functional signature in microglia.
- Clinical Outcomes Following Surgical Management of Coexistent Cervical Stenosis and Multiple Sclerosis: A Cohort Controlled Analysis.
- Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2(+) glial cells.
- Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events.
- Regulation of Adaptive Immunity by the Fractalkine Receptor during Autoimmune Inflammation.
- Functional defect of peripheral neutrophils in mice with induced deletion of CXCR2.
- Editors' preface: Microglia-A new era dawns.
- Animal models of Multiple sclerosis: the good, the bad and the bottom line.
- Chemokine CXCL12 in neurodegenerative diseases: an SOS signal for stem cell-based repair.
- Perspective: Let the sunshine in!
- Re-establishing immunological self-tolerance in autoimmune disease.
- Inflammatory cortical demyelination in early Multiple sclerosis.
- The role of cell type-specific responses in IFN-? therapy of Multiple sclerosis.
- The Fractalkine Receptor but Not CCR2 Is Present on Microglia from Embryonic Development throughout Adulthood.
- Multiple sclerosis normal-appearing white matter: Pathology-imaging correlations.
- Neuroscience. How many cell types does it take to wire a brain?
- Immunological and clinical consequences of treating a patient with natalizumab.
- MMP9 deficiency does not decrease blood-brain barrier disruption, but increases astrocyte MMP3 expression during viral encephalomyelitis.
- CX3CR1 modulates microglial activation and protects against plaque-independent cognitive deficits in a mouse model of Alzheimer's disease.
- Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages.
- Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair.
- CXCR2 signaling protects oligodendrocyte progenitor cells from IFN-γ/CXCL10-mediated apoptosis.
- G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands.
- CXCR3 dependent plasma blast migration to the central nervous system during viral encephalomyelitis.
- Impaired respiratory function in mdx and mdx/utrn(+/-) mice.
- Heterogeneity of CNS myeloid cells and their roles in neurodegeneration.
- Microglia and monocytes: 'tis plain the twain meet in the brain.
- Macrophages recruited via CCR2 produce insulin-like growth factor-1 to repair acute skeletal muscle injury.
- Chemokine receptor CXCR4 signaling modulates the growth factor-induced cell cycle of self-renewing and multipotent neural progenitor cells.
- Excessive biologic response to IFNβ is associated with poor treatment response in patients with Multiple sclerosis.
- Major differences in the responses of primary human leukocyte subsets to IFN-beta.
- CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models.
- Regulation of tau pathology by the microglial fractalkine receptor.
- Myelin repair is accelerated by inactivating CXCR2 on nonhematopoietic cells.
- Turning over the Chance card on MS susceptibility.
- Expression of fractalkine receptor CX3CR1 on cochlear macrophages influences survival of hair cells following ototoxic injury.
- Monocytes regulate T cell migration through the glia limitans during acute viral encephalitis.
- Astrocyte-restricted ablation of interleukin-17-induced Act1-mediated signaling ameliorates autoimmune encephalomyelitis.
- CXCR2-positive neutrophils are essential for cuprizone-induced demyelination: relevance to Multiple sclerosis.
- STAT-phosphorylation-independent induction of interferon regulatory factor-9 by interferon-beta.
- CXCR2 signaling protects oligodendrocytes and restricts demyelination in a mouse model of viral-induced demyelination.
- Selective chemokine receptor usage by central nervous system myeloid cells in CCR2-red fluorescent protein knock-in mice.
- Roles of IKK-beta, IRF1, and p65 in the activation of chemokine genes by interferon-gamma.
- Heterogeneous, longitudinally stable molecular signatures in response to interferon-beta.
- Chemokines and chemokine receptors: standing at the crossroads of immunobiology and neurobiology.
- A protective role for ELR+ chemokines during acute viral encephalomyelitis.
- Immunotherapy for Multiple sclerosis: the curious case of interferon beta.
- Natalizumab, Multiple sclerosis, and primary central nervous system lymphoma: enigma, wrapped in mystery, enclosed in conundrum.
- Imatinib attenuates skeletal muscle dystrophy in mdx mice.
- AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice.
- Localizing central nervous system immune surveillance: meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis.
- Effect of plasma exchange in accelerating natalizumab clearance and restoring leukocyte function.
- Double-label nonradioactive in situ hybridization for the analysis of chemokine receptor expression in the central nervous system.
- Microglial physiology: unique stimuli, specialized responses.
- CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction.
- Imaging correlates of leukocyte accumulation and CXCR4/CXCL12 in Multiple sclerosis.
- Memory CD4+ T-cell-mediated protection from lethal coronavirus encephalomyelitis.
- Chemokines in and out of the central nervous system: much more than chemotaxis and inflammation.
- Non-cell-autonomous effects of presenilin 1 variants on enrichment-mediated hippocampal progenitor cell proliferation and differentiation.
- Translating research into treatments.
- Scavenging roles of chemokine receptors: chemokine receptor deficiency is associated with increased levels of ligand in circulation and tissues.
- Is microglial apoptosis an early pathogenic change in cerebral X-linked adrenoleukodystrophy?
- Biomarkers for interferon response in MS: are we there yet?
- Repopulation of cochlear macrophages in murine hematopoietic progenitor cell chimeras: the role of CX3CR1.
- Leukemia inhibitory factor deficiency modulates the immune response and limits autoimmune demyelination: a new role for neurotrophic cytokines in neuroinflammation.
- Cortical demyelination in PML and MS: Similarities and differences.
- Human brain microvascular endothelial cells and umbilical vein endothelial cells differentially facilitate leukocyte recruitment and utilize chemokines for T cell migr...
- Microgliosis: the questions shape the answers.
- Novel interferon-beta-induced gene expression in peripheral blood cells.
- Chemokines and chemokine receptors in neurological disease: raise, retain, or reduce?
- Neuroimmunotherapeutics comes of age.
- Disrupted cardiac development but normal hematopoiesis in mice deficient in the second CXCL12/SDF-1 receptor, CXCR7.
- PDGF synergistically enhances IFN-gamma-induced expression of CXCL10 in blood-derived macrophages: implications for HIV dementia.
- Requirement of catalytically active Tyk2 and accessory signals for the induction of TRAIL mRNA by IFN-beta.
- Progressive multifocal leukoencephalopathy in rheumatic diseases: evolving clinical and pathologic patterns of disease.
- Inflammatory progressive multifocal leukoencephalopathy in human immunodeficiency virus-negative patients.
- Natalizumab for Multiple sclerosis.
- Chemokines and chemokine receptors: multipurpose players in neuroinflammation.
- CC chemokine receptor 2 is protective against noise-induced hair cell death: studies in CX3CR1(+/GFP) mice.
- A novel model of demyelinating encephalomyelitis induced by monocytes and dendritic cells.
- Interferon-gamma-inducible protein (IP)-10 mRNA stabilized by RNA-binding proteins in monocytes treated with S100b.
- Alterations in the oligodendrocyte lineage, myelin, and white matter in adult mice lacking the chemokine receptor CXCR2.
- A mighty mouse: building a better model of Multiple sclerosis.
- CCR5 expression on monocytes and T cells: modulation by transmigration across the blood-brain barrier in vitro.
- Cutting edge: the silent chemokine receptor D6 is required for generating T cell responses that mediate experimental autoimmune encephalomyelitis.
- T cell-intrinsic ASC critically promotes TH17-mediated experimental autoimmune encephalomyelitis.
Schools
Case Western Reserve University School of Medicine
Cleveland Clinic
Mt Sinai Hospital
Case West Res University School Med
Procedures Preformed
- EMG (Electromyography)
Conditions Treated
- Ataxia
- Dystonia
- Epilepsy
- Gait Abnormality
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Doctors Specialties
- Internal Medicine
- Neurology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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Cleveland Clinic Foundation -
Mount Sinai Medical Center -
Case Western Reserve University School of Medicine
Hospital
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Cleveland Clinic
Drug Facts
| NPI NUMBER | 1881620698 | |
| NPPES Provider LastName | RANSOHOFF | |
| NPPES Provider FirstName | RICHARD | |
| NPPES Provider ZIPCode | 441950001 | |
| NPPES Provider State | OH | |
| Specialty Description | Neurology | |
| Total Claim Count | 17.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1881620698 |
| Last Name Of The Provider | RANSOHOFF |
| First Name Of The Provider | RICHARD |
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