Professor and Chief of Pediatric Infectious Diseases, Emory DOP Chief Research Officer, CHOA
Pediatric Infectious Disease
Dr. Paul W. Spearman, MD
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Dr. Paul W. Spearman works in the field of Pediatric Infectious Disease. He attended University of Texas Southwestern Medical School. He received 1 awards: "Fellow (FAAP)". Paul W. Spearman is a published doctor. He has 99 papers published. The most current publication "Acute aseptic meningitis secondary to intravenous immunoglobulin in a patient with Kawasaki syndrome."
Publications
- Low frequency of broadly neutralizing HIV antibodies during chronic infection even in quaternary epitope targeting antibodies containing large numbers of somatic mutat...
- Acute pancreatitis associated with dolutegravir and lamivudine/abacavir administration.
- Point-of-Use Mixing of Influenza H5N1 Vaccine and MF59 Adjuvant for Pandemic Vaccination Preparedness: Antibody Responses and Safety. A Phase 1 Clinical Trial.
- Serological responses to an avian influenza A/H7N9 vaccine mixed at the point-of-use with MF59 adjuvant: a randomized clinical trial.
- Immunogenicity of avian influenza A/Anhui/01/2005(H5N1) vaccine with MF59 adjuvant: a randomized clinical trial.
- Immunogenicity and safety of four different dosing regimens of anthrax vaccine adsorbed for post-exposure prophylaxis for anthrax in adults.
- Microscale generation of cardiospheres promotes robust enrichment of cardiomyocytes derived from human pluripotent stem cells.
- ROCK1 and LIM Kinase Modulate Retrovirus Particle Release and Cell-Cell Transmission Events.
- Direct evidence for intracellular anterograde co-transport of M-PMV Gag and Env on microtubules.
- Capturing Enveloped Viruses on Affinity Grids for Downstream Cryo-Electron Microscopy Applications.
- Rab11-FIP1C and Rab14 Direct Plasma Membrane Sorting and Particle Incorporation of the HIV-1 Envelope Glycoprotein Complex.
- Neonatal infectious diseases: evaluation of neonatal sepsis.
- Unraveling the structural basis of HIV-1 neutralization.
- Tetherin/BST-2 Is Essential for the Formation of the Intracellular Virus-Containing Compartment in HIV-Infected Macrophages.
- Restriction of Retroviral Replication by Tetherin/BST-2.
- Pseudovirion particles bearing native HIV envelope trimers facilitate a novel method for generating human neutralizing monoclonal antibodies against HIV.
- Placental Hofbauer cells assemble and sequester HIV-1 in tetraspanin-positive compartments that are accessible to broadly neutralizing antibodies.
- An siRNA Screen of Membrane Trafficking Genes Highlights Pathways Common to HIV-1 and M-PMV Virus Assembly and Release.
- A Mason-Pfizer Monkey Virus Gag-GFP Fusion Vector Allows Visualization of Capsid Transport in Live Cells and Demonstrates a Role for Microtubules.
- Optical transverse excitation in quaterthiophene crystals by ultraviolet-visible internal and attenuated total reflection.
- Directional dispersion in absorbance spectra of oligothiophene crystals.
- Polarized absorption of quaterthiophene single crystals.
- Reflectivity and anisotropic optical functions of quaterthiophene single crystals.
- Exciton self-trapping in tetrafluoro-dimethyl-aminoacridine single crystals.
- Dielectric tensor of tetracene single crystals: the effect of anisotropy on polarized absorption and emission spectra.
- Reclassifying exciton-phonon coupling in molecular aggregates: evidence of strong nonadiabatic coupling in oligothiophene crystals.
- Expression of vaccinia E3L and K3L genes by a novel recombinant canarypox HIV vaccine vector enhances HIV-1 pseudovirion production and inhibits apoptosis in human cells.
- Intrinsic excitonic luminescence in odd and even numbered oligothiophenes.
- Two phases of HIV RNA decay in CSF during initial days of multidrug therapy.
- Effect of static and dynamic disorder on exciton mobility in oligothiophenes.
- Measured Davydov splitting in oligothiophene crystals.
- Human immunodeficiency virus replication in a primary effusion lymphoma cell line stimulates lytic-phase replication of Kaposi's sarcoma-associated herpesvirus.
- Efficient human immunodeficiency virus ( HIV)-1 Gag-Env pseudovirion formation elicited from mammalian cells by a canarypox HIV vaccine candidate.
- Neutralizing antibody responses in Africa green monkeys naturally infected with simian immunodeficiency virus (SIVagm).
- Formation and release of virus-like particles by HIV-1 matrix protein.
- Acute aseptic meningitis secondary to intravenous immunoglobulin in a patient with Kawasaki syndrome.
- The I domain is required for efficient plasma membrane binding of human immunodeficiency virus type 1 Pr55Gag.
- Dracunculiasis: report of an imported case in the United States.
- Membrane binding of human immunodeficiency virus type 1 matrix protein in vivo supports a conformational myristyl switch mechanism.
- Sternoclavicular joint septic arthritis with small-colony variant Staphylococcus aureus.
- Human immunodeficiency virus type 1 capsid formation in reticulocyte lysates.
- Human immunodeficiency virus type 1 viral protein R localization in infected cells and virions.
- Identification of human immunodeficiency virus type 1 Gag protein domains essential to membrane binding and particle assembly.
- HIV-2 viral protein X association with the GAG p27 capsid protein.
- Persistent left superior vena cava: unusual wave contour of left jugular vein as the presenting feature.
- Comparison of human immunodeficiency virus type 1 RNA sequence heterogeneity in cerebrospinal fluid and plasma.
- Steady-state pharmacokinetics of indinavir in cerebrospinal fluid and plasma among adults with human immunodeficiency virus type 1 infection.
- Evidence of a source of HIV type 1 within the central nervous system by ultraintensive sampling of cerebrospinal fluid and plasma.
- Mapping and characterization of the N-terminal I domain of human immunodeficiency virus type 1 Pr55(Gag).
- The N-terminal matrix domain of HIV-1 Gag is sufficient but not necessary for viral protein U-mediated enhancement of particle release through a membrane-targeting mec...
- Tracking the assembly pathway of human immunodeficiency virus type 1 Gag deletion mutants by immunogold labeling.
- Mycobacteria fortuitum central venous catheter-related bacteremia in an infant with renal sarcoma.
- Comparison of Roche MONITOR and Organon Teknika NucliSens assays to quantify human immunodeficiency virus type 1 RNA in cerebrospinal fluid.
- QS-21 promotes an adjuvant effect allowing for reduced antigen dose during HIV-1 envelope subunit immunization in humans.
- A RhoA-derived peptide inhibits syncytium formation induced by respiratory syncytial virus and parainfluenza virus type 3.
- Toxic shock syndrome occurring in children with abrasive injuries beneath casts.
- The Tetherin/BST-2 Coiled-Coil Ectodomain Mediates Plasma Membrane Microdomain Localization and Restriction of Particle Release.
- Filamin A protein interacts with human immunodeficiency virus type 1 Gag protein and contributes to productive particle assembly.
- Tetherin does not significantly restrict dendritic cell-mediated HIV-1 transmission and its expression is upregulated by newly synthesized HIV-1 Nef.
- Nucleosides accelerate inflammatory osteolysis, acting as distinct innate immune activators.
- A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteers.
- Identification of a single amino acid required for APOBEC3 antiretroviral cytidine deaminase activity.
- Safety and immunogenicity of influenza A H5 subunit vaccines: effect of vaccine schedule and antigenic variant.
- Advances in methods for the production, purification, and characterization of HIV-1 Gag-Env pseudovirion vaccines.
- Myristoylation is required for human immunodeficiency virus type 1 Gag-Gag multimerization in mammalian cells.
- A novel fluorescence resonance energy transfer assay demonstrates that the human immunodeficiency virus type 1 Pr55Gag I domain mediates Gag-Gag interactions.
- Viral protein U counteracts a human host cell restriction that inhibits HIV-1 particle production.
- An imperfect rule for the particle roost.
- Immunoelectron microscopic evidence for Tetherin/BST2 as the physical bridge between HIV-1 virions and the plasma membrane.
- CAML does not modulate tetherin-mediated restriction of HIV-1 particle release.
- Human immunodeficiency virus type-1 gag and host vesicular trafficking pathways.
- Tetherin is as tetherin does.
- Neisseria sicca/subflava bacteremia presenting as cutaneous nodules in an immunocompromised host.
- Cellular cofactors involved in HIV assembly and budding.
- Characterization of a myristoylated, monomeric HIV Gag protein.
- Safety and immunogenicity of a CTL multiepitope peptide vaccine for HIV with or without GM-CSF in a phase I trial.
- Human metapneumovirus nucleoprotein and phosphoprotein interact and provide the minimal requirements for inclusion body formation.
- Identification of calcium-modulating cyclophilin ligand as a human host restriction to HIV-1 release overcome by Vpu.
- Distinct viral determinants for the packaging of human cytidine deaminases APOBEC3G and APOBEC3C.
- The impact of cesarean delivery on transmission of infectious agents to the neonate.
- Direct comparison of antigen production and induction of apoptosis by canarypox virus- and modified vaccinia virus ankara-human immunodeficiency virus vaccine vectors.
- APOBEC3G multimers are recruited to the plasma membrane for packaging into human immunodeficiency virus type 1 virus-like particles in an RNA-dependent process requiri...
- Durable HIV-1 antibody and T-cell responses elicited by an adjuvanted multi-protein recombinant vaccine in uninfected human volunteers.
- HIV vaccine development: lessons from the past and promise for the future.
- Current progress in the development of HIV vaccines.
- The pericentriolar recycling endosome plays a key role in Vpu-mediated enhancement of HIV-1 particle release.
- Induction of neutralizing antibodies against human immunodeficiency virus type 1 primary isolates by Gag-Env pseudovirion immunization.
- Interaction of HIV-1 Gag with the clathrin-associated adaptor AP-2.
- High-dose recombinant Canarypox vaccine expressing HIV-1 protein, in seronegative human subjects.
- Pseudovirion particle production by live poxvirus human immunodeficiency virus vaccine vector enhances humoral and cellular immune responses.
- AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly.
- HIV-1 egress is gated through late endosomal membranes.
- Gp120 stability on HIV-1 virions and Gag-Env pseudovirions is enhanced by an uncleaved Gag core.
- Independent segregation of human immunodeficiency virus type 1 Gag protein complexes and lipid rafts.
- Human immunodeficiency virus type-1 activates lytic cycle replication of Kaposi's sarcoma-associated herpesvirus through induction of KSHV Rta.
- Safety and immunogenicity of a high-titered canarypox vaccine in combination with rgp120 in a diverse population of HIV-1-uninfected adults: AIDS Vaccine Evaluation Gr...
- Comparison of systemic and mucosal delivery of 2 canarypox virus vaccines expressing either HIV-1 genes or the gene for rabies virus G protein.
- Emerging studies of human HIV-specific antibody repertoires.
Schools
University of Texas Southwestern Medical Center At Dallas
Ohio St University
Wash University School Med
Doctors Specialties
- Infectious Disease Medicine
- Pediatric Infectious Disease Medicine
- Pediatric Infectious Disease
Accepted Insurances
Awards
- Fellow (FAAP)
Education
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Washington University - Barnes-Jewish Hospital -
Ohio State University Hospital -
University of Texas Southwestern Medical School
Hospital
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Children's Healthcare of Atlanta -
Grady Memorial Hospital -
Northside Hospital
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