Professor, Diabetes Center, UCSF School of Medicine
Internal Medicine
Dr. Michael S. German, MD
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Dr. Michael S. German practices Internal Medicine. He went to medical school at University of Texas Southwestern Medical School. He received 1 awards: "Elected Member". Michael S. German is a published doctor. He has 100 papers published. The most current publication "A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets."
Publications
- Activation of GLP-1 and gastrin signalling induces in vivo reprogramming of pancreatic exocrine cells into beta cells in mice.
- Reprogramming of human pancreatic exocrine cells to β-like cells.
- Use of copolymer polylactic and polyglycolic Acid resorbable plates in repair of orbital floor fractures.
- Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress.
- Chronological analysis with Fluorescent Timer reveals unique features of newly generated β cells.
- Transient cytokine treatment induces acinar cell reprogramming and regenerates functional beta cell mass in diabetic mice.
- A novel approach for surgical repair of dehiscent high jugular bulb.
- Research Resource: RNA-Seq Reveals Unique Features of the Pancreatic β-Cell Transcriptome.
- Adenosine signaling promotes regeneration of pancreatic β cells in vivo.
- An siRNA Screen in Pancreatic Beta Cells Reveals a Role for Gpr27 in Insulin Production.
- Convergence of the Insulin and Serotonin Programs in the Pancreatic {beta}-Cell.
- Novel Role for SGK3 in Glucose Homeostasis Revealed in SGK3/Akt2 Double-Null Mice.
- Association of Variations in TPH1 and HTR2B with Gestational Weight Gain and Measures of Obesity.
- Chromatin Insulator Elements Block Transgene Silencing in Engineered hESC Lines at a Defined Chromosome 13 Locus.
- Effects of biotin deficiency on pancreatic islet morphology, insulin sensitivity and glucose homeostasis.
- Neurogenin3 inhibits proliferation in endocrine progenitors by inducing Cdkn1a.
- Dachshund homologues play a conserved role in islet cell development.
- Serotonin regulates pancreatic beta cell mass during pregnancy.
- Current status of islet cell replacement and regeneration therapy.
- Chronology of islet differentiation revealed by temporal cell labeling.
- The role of Lmx1a in the differentiation of human embryonic stem cells into midbrain dopamine neurons in culture and after transplantation into a Parkinson's disease m...
- Mouse let-7 miRNA populations exhibit RNA editing that is constrained in the 5'-seed/ cleavage/anchor regions and stabilize predicted mmu-let-7a:mRNA duplexes.
- New beta-cells from old acini.
- Identification of the bHLH factor Math6 as a novel component of the embryonic pancreas transcriptional network.
- MicroRNA expression is required for pancreatic islet cell genesis in the mouse.
- The HMG box transcription factor Sox4 contributes to the development of the endocrine pancreas.
- Hedgehog signaling regulates expansion of pancreatic epithelial cells.
- MAP kinases and their roles in pancreatic beta-cells.
- Neurogenin3 activates the islet differentiation program while repressing its own expression.
- Pdx1 expression in Irs2-deficient mouse beta-cells is regulated in a strain-dependent manner.
- Neurogenin3 and hepatic nuclear factor 1 cooperate in activating pancreatic expression of Pax4.
- Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity by multiple mechanisms.
- Regulation of insulin gene transcription by ERK1 and ERK2 in pancreatic beta cells.
- Activated Notch1 prevents differentiation of pancreatic acinar cells and attenuate endocrine development.
- p38 MAPK is involved in activin A- and hepatocyte growth factor-mediated expression of pro-endocrine gene neurogenin 3 in AR42J-B13 cells.
- Distinct gene expression programs function in progenitor and mature islet cells.
- [Pathomorphologic changes in the myometrium of parturients following cesarean section].
- Cloning of rat KATP-2 channel and decreased expression in pancreatic islets of male Zucker diabetic fatty rats.
- Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13.
- Isolation of a cDNA clone encoding a KATP channel-like protein expressed in insulin-secreting cells, localization of the human gene to chromosome band 21q22.1, and lin...
- The minisatellite in the Diabetes susceptibility locus IDDM2 regulates insulin transcription.
- Pancreatic beta cells express a diverse set of homeobox genes.
- The insulin gene contains multiple transcriptional elements that respond to glucose.
- Glucose sensing in pancreatic islet beta cells: the key role of glucokinase and the glycolytic intermediates.
- Function of the human insulin promoter in primary cultured islet cells.
- A strongly inwardly rectifying K+ channel that is sensitive to ATP.
- Isolation, characterization, and chromosomal mapping of the human Nkx6.1 gene (NKX6A), a new pancreatic islet homeobox gene.
- The beta cell transcription factors and development of the pancreas.
- Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity.
- Genetic analysis reveals that PAX6 is required for normal transcription of pancreatic hormone genes and islet development.
- The endocrine secretion of human insulin and growth hormone by exocrine glands of the gastrointestinal tract.
- Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9.
- Mice lacking the homeodomain transcription factor Nkx2.2 have Diabetes due to arrested differentiation of pancreatic beta cells.
- Beta-cell transcription factors and Diabetes: mutations in the coding region of the BETA2/NeuroD1 (NEUROD1) and Nkx2.2 (NKX2B) genes are not associated with maturity-o...
- A novel glucose-responsive element in the human insulin gene functions uniquely in primary cultured islets.
- Effect of retinoic acid on glucokinase activity and gene expression and on insulin secretion in primary cultures of pancreatic islets.
- Biotin regulation of pancreatic glucokinase and insulin in primary cultured rat islets and in biotin-deficient rats.
- Paired-homeodomain transcription factor PAX4 acts as a transcriptional repressor in early pancreatic development.
- The homeodomain of PDX-1 mediates multiple protein-protein interactions in the formation of a transcriptional activation complex on the insulin promoter.
- LMX1B transactivation and expression in nail-patella syndrome.
- Beta-cell differentiation factor Nkx6.1 contains distinct DNA binding interference and transcriptional repression domains.
- Expression of neurogenin3 reveals an islet cell precursor population in the pancreas.
- Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1.
- Intramolecular control of transcriptional activity by the NK2-specific domain in NK-2 homeodomain proteins.
- Proendocrine genes coordinate the pancreatic islet differentiation program in vitro.
- Ventral neural patterning by Nkx homeobox genes: Nkx6.1 controls somatic motor neuron and ventral interneuron fates.
- The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells.
- Regulation of insulin preRNA splicing by glucose.
- Homeobox gene Nkx6.1 lies downstream of Nkx2.2 in the major pathway of beta-cell formation in the pancreas.
- Notch signaling as gatekeeper of rat acinar-to-beta-cell conversion in vitro.
- Neurogenin3 participates in gliogenesis in the developing vertebrate spinal cord.
- Region-specific and stage-dependent regulation of Olig gene expression and oligodendrogenesis by Nkx6.1 homeodomain transcription factor.
- The insulin gene promoter. A simplified nomenclature.
- Regulation of insulin gene transcription.
- The Gene Pill and its therapeutic applications.
- Genotyping of Toxoplasma gondii strains from immunocompromised patients reveals high prevalence of Type I strains.
- Prolonged Jackson-Pratt drainage in the management of lumbar cerebrospinal fluid leaks.
- Feeding behavior modulation in the leopard lizard (Gambelia wislizenii): effects of noxious versus innocuous prey.
- Differentiation of human embryonic stem cells into pancreatic endoderm in patterned size-controlled clusters.
- Rfx6 directs islet formation and insulin production in mice and humans.
- Precise pattern of recombination in serotonergic and hypothalamic neurons in a Pdx1-cre transgenic mouse line.
- A mouse model for monitoring islet cell genesis and developing therapies for Diabetes.
- Derivation of insulin-producing cells from human embryonic stem cells.
- The ETS oncogene family transcription factor FEV identifies serotonin-producing cells in normal and neoplastic small intestine.
- PAX4 gene variations predispose to ketosis-prone Diabetes.
- Signals from the neural crest regulate beta-cell mass in the pancreas.
- Homeodomain transcription factor NKX2.2 functions in immature cells to control enteroendocrine differentiation and is expressed in gastrointestinal neuroendocrine tumors.
- Induction of pancreatic islet cell differentiation by the neurogenin-neuroD cascade.
- Activin A-induced expression of PAX4 in AR42J-B13 cells involves the increase in transactivation of E47/E12.
- Gene expression cascades in pancreatic development.
- Hnf6 and Tcf2 (MODY5) are linked in a gene network operating in a precursor cell domain of the embryonic pancreas.
- Expression pattern of IAPP and prohormone convertase 1/3 reveals a distinctive set of endocrine cells in the embryonic pancreas.
- Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians.
- Autoregulation and maturity onset Diabetes of the young transcription factors control the human PAX4 promoter.
- beta-cell transcription factors and Diabetes: no evidence for Diabetes-associated mutations in the gene encoding the basic helix-loop-helix transcription factor neurog...
- A genetic defect in beta-cell gene expression segregates independently from the fa locus in the ZDF rat.
- Mutations in the coding region of the neurogenin 3 gene (NEUROG3) are not a common cause of maturity-onset Diabetes of the young in Japanese subjects.
- Cyclic adenosine 3',5'-monophosphate increases pancreatic glucokinase activity and gene expression.
- Regulation of the pancreatic pro-endocrine gene neurogenin3.
Schools
University of Texas Southwestern Medical Center At Dallas
University Ca Sf School Of Med
University Med Center
Conditions Treated
- Diabetes Type 1
- Diabetes Type 2
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
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UCSF -
University of Arizona -
University of Texas Southwestern Medical School
Hospital
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San Francisco General Hospital and Trauma Center -
UCSF Medical Center
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