Professor, Pathology, University of Washington School of Medicine

Internal Medicine

Marshall Horwitz practices Internal Medicine. He went to medical school at University of Washington School of Medicine. He over the years received 1 awards: "Super Doctor". Marshall Horwitz is also a published doctor. He has 40 paper published. The most recent paper is: Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.

Publications

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• Germline ETV6 mutations in familial thrombocytopenia and hematologic malignancy.
• Clonal expansions and short telomeres are associated with neoplasia in early-onset, but not late-onset, ulcerative colitis.
• Neutropenia-associated ELANE mutations disrupting translation initiation produce novel neutrophil elastase isoforms.
• A recurrent germline PAX5 mutation confers susceptibility to pre-B cell acute lymphoblastic leukemia.
• Support for the N-methyl-D-aspartate receptor hypofunction hypothesis of schizophrenia from exome sequencing in multiplex families.
• Mitotic errors, aneuploidy and micronuclei in Hodgkin lymphoma pathogenesis.
• The Kelch Protein KLHDC8B Guards against Mitotic Errors, Centrosomal Amplification, and Chromosomal Instability.
• HIF1α induced switch from bivalent to exclusively glycolytic metabolism during ESC-to-EpiSC/hESC transition.
• Loss-of-function germline GATA2 mutations in patients with MDS/AML or MonoMAC syndrome and primary lymphedema reveal a key role for GATA2 in the lymphatic vasculature.
• Decoding cell lineage from acquired mutations using arbitrary deep sequencing.
• Target protein interactions of indole-3-carbinol and the highly potent derivative 1-Benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest...
• Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia.
• Assessment of Hypoxia Inducible Factor Levels in Cancer Cell Lines upon Hypoxic Induction Using a Novel Reporter Construct.
• Neutrophil elastase, proteinase 3, and cathepsin G as therapeutic targets in human diseases.
• KLHDC8B in Hodgkin lymphoma and possibly twinning.
• Mutations in a gene encoding a midbody protein in binucleated Reed-Sternberg cells of Hodgkin lymphoma.
• Phylogenetic analysis of developmental and postnatal mouse cell lineages.
• Clonal expansions in ulcerative colitis identify patients with neoplasia.
• Adenovirus E3 MHC inhibitory genes but not TNF/Fas apoptotic inhibitory genes expressed in beta cells prevent autoimmune diabetes.
• Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells.
• Contributions to neutropenia from PFAAP5 (N4BP2L2), a novel protein mediating transcriptional repressor cooperation between Gfi1 and neutrophil elastase.
• Neutropenia in 6 ethnic groups from the Caribbean and the U.S.
• Lymphadenopathy as the primary manifestation of malignant transformation in two patients with severe congenital neutropenia.
• Phylogenetic fate mapping: theoretical and experimental studies applied to the development of mouse fibroblasts.
• Epigenetic regulation of protein-coding and microRNA genes by the Gfi1-interacting tumor suppressor PRDM5.
• Double de novo mutations of ELA2 in cyclic and severe congenital neutropenia.
• The clinical, immunohematological, and molecular study of Iranian patients with severe congenital neutropenia.
• Neutrophil elastase in cyclic and severe congenital neutropenia.
• Prevention of hepatocyte allograft rejection in rats by transferring adenoviral early region 3 genes into donor cells.
• A phylogenetic approach to mapping cell fate.
• Adenovirus RIDalphabeta complex inhibits lipopolysaccharide signaling without altering TLR4 cell surface expression.
• Phylogenetic fate mapping.
• Mechanism for removal of tumor necrosis factor receptor 1 from the cell surface by the adenovirus RIDalpha/beta complex.
• Adenovirus early region 3 transgenes expressed in beta cells prevent autoimmune diabetes in nonobese diabetic mice: effects of deleting the adenovirus death protein 11...
• Inhibition of tumor necrosis factor (TNF) signal transduction by the adenovirus group C RID complex involves downregulation of surface levels of TNF receptor 1.
• Inhibition of chemokine expression by adenovirus early region three (E3) genes.
• Inhibition of tumor necrosis factor alpha-induced NF-kappa B activation by the adenovirus E3-10.4/14.5K complex.
• Evolution of adenoviruses as gene therapy vectors.
• Genome sequencing of idiopathic pulmonary fibrosis in conjunction with a medical school human anatomy course.

Schools

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• University Of Washington School Of Medicine

Doctors Specialties

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• Clinical Genetics
• Internal Medicine

Accepted Insurances

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Awards

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• Super Doctor

Education

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• University of Washington
• University of Washington School of Medicine

Hospital

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• Seattle Children's Hospital
• University of Washington Medical Center

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