Physician
Neurology
Dr. Mark E. Von Zastrow, MD
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Mark Zastrow is an expert in the field of Neurology. He went to medical school at Yale University School of Medicine. Yale University School of Medicine is a top medical college. Yale University School of Medicine has a rank of 7 in research and a 57 in primary care Mark E. Von Zastrow, MD is a published doctor and has 67 publications published. The lastest was: 'Ubiquitination in the first cytoplasmic loop of ?-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation.'
Publications
- An approach to the molecular biology of opiate tolerance: identification of opiate-regulated transcripts.
- Ubiquitination in the first cytoplasmic loop of ?-opioid receptors reveals a hierarchical mechanism of lysosomal down-regulation.
- Role of PDZ proteins in regulating trafficking, signaling, and function of GPCRs: means, motif, and opportunity.
- Investigating G protein-coupled receptor endocytosis and trafficking by TIR-FM.
- Quantitative encoding of the effect of a partial agonist on individual opioid receptors by multisite phosphorylation and threshold detection.
- Endocytosis promotes rapid dopaminergic signaling.
- Analysis of GPCR localization and trafficking.
- SNX27 mediates retromer tubule entry and endosome-to-plasma membrane trafficking of signalling receptors.
- Recovery from mu-opioid receptor desensitization after chronic treatment with morphine and methadone.
- Sequence-dependent sorting of recycling proteins by actin-stabilized endosomal microdomains.
- The role of ubiquitination in lysosomal trafficking of δ-opioid receptors.
- {Beta}-blocker drugs mediate calcium signaling in native central nervous system neurons by {beta}-arrestin-biased agonism.
- Role of ubiquitination in endocytic trafficking of G-protein-coupled receptors.
- Rapid delivery of internalized signaling receptors to the somatodendritic surface by sequence-specific local insertion.
- SNX27 mediates PDZ-directed sorting from endosomes to the plasma membrane.
- DISC1 regulates primary cilia that display specific dopamine receptors.
- Regulation of opioid receptors by endocytic membrane traffic: mechanisms and translational implications.
- Association of mu-opioid receptor variants and response to citalopram treatment in major depressive disorder.
- Dysbindin promotes the post-endocytic sorting of G protein-coupled receptors to lysosomes.
- Functional characterization of vasopressin type 2 receptor substitutions (R137H/C/L) leading to nephrogenic diabetes insipidus and nephrogenic syndrome of inappropriat...
- Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking.
- Endocytosis and signalling: intertwining molecular networks.
- Ubiquitination regulates proteolytic processing of G protein-coupled receptors after their sorting to lysosomes.
- Cargo-mediated regulation of a rapid Rab4-dependent recycling pathway.
- Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons.
- Engineered protein connectivity to actin mimics PDZ-dependent recycling of G protein-coupled receptors but not its regulation by Hrs.
- Alternative splicing determines the post-endocytic sorting fate of G-protein-coupled receptors.
- Differential activation and trafficking of micro-opioid receptors in brain slices.
- The ubiquitin-like protein PLIC-2 is a negative regulator of G protein-coupled receptor endocytosis.
- Regulation of GPCRs by endocytic membrane trafficking and its potential implications.
- Real-time imaging of discrete exocytic events mediating surface delivery of AMPA receptors.
- Endocytosis of neurotransmitter receptors: location matters.
- Signaling on the endocytic pathway.
- N-ethylmaleimide-sensitive factor regulates beta2 adrenoceptor trafficking and signaling in cardiomyocytes.
- Microtubule plus-end-tracking proteins target gap junctions directly from the cell interior to adherens junctions.
- A novel sorting sequence in the beta2-adrenergic receptor switches recycling from default to the Hrs-dependent mechanism.
- Cargo regulates clathrin-coated pit dynamics.
- Functional selectivity and classical concepts of quantitative pharmacology.
- Distinct modes of regulated receptor insertion to the somatodendritic plasma membrane.
- Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways.
- Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons.
- Chemical genetic engineering of G protein-coupled receptor kinase 2.
- Essential role of Hrs in a recycling mechanism mediating functional resensitization of cell signaling.
- Mass spectrometric analysis of agonist effects on posttranslational modifications of the beta-2 adrenoceptor in mammalian cells.
- Type I PDZ ligands are sufficient to promote rapid recycling of G Protein-coupled receptors independent of binding to N-ethylmaleimide-sensitive factor.
- The composition of the beta-2 adrenergic receptor oligomer affects its membrane trafficking after ligand-induced endocytosis.
- A cell biologist''s perspective on physiological adaptation to opiate drugs.
- Identification of protein interactions by yeast two-hybrid screening and coimmunoprecipitation.
- Identification of a novel endocytic recycling signal in the D1 dopamine receptor.
- Role of mammalian vacuolar protein-sorting proteins in endocytic trafficking of a non-ubiquitinated G protein-coupled receptor to lysosomes.
- Opioid receptor regulation.
- Mechanisms regulating membrane trafficking of G protein-coupled receptors in the endocytic pathway.
- A novel endocytic recycling signal that distinguishes the membrane trafficking of naturally occurring opioid receptors.
- Regulated endocytosis of opioid receptors: cellular mechanisms and proposed roles in physiological adaptation to opiate drugs.
- Spatial regulation of Galphai protein signaling in clathrin-coated membrane microdomains containing GAIP.
- Morphine acutely regulates opioid receptor trafficking selectively in dendrites of nucleus accumbens neurons.
- Neurotrophin-regulated sorting of opioid receptors in the biosynthetic pathway of neurosecretory cells.
- Constitutive activation and endocytosis of the complement factor 5a receptor: evidence for multiple activated conformations of a G protein-coupled receptor.
- Ubiquitination-independent trafficking of G protein-coupled receptors to lysosomes.
- A novel anterograde trafficking signal present in the N-terminal extracellular domain of ionotropic glutamate receptors.
- Signal transduction and endocytosis: close encounters of many kinds.
- Modulation of postendocytic sorting of G protein-coupled receptors.
- mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization.
- Control of synaptic strength by glial TNFalpha.
- Regulation of opioid receptor trafficking and morphine tolerance by receptor oligomerization.
- Amplified RNA synthesized from limited quantities of heterogeneous cDNA.
Schools
Yale University
Stanford University
Doctors Specialties
- Psychiatry
- Neurology
Accepted Insurances
Education
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Stanford University -
Yale University School of Medicine
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