Physician
Endocrinology
Dr. Marc K. Hellerstein, MD
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Marc K. Hellerstein is an expert in the field of Endocrinology. He graduated from Yale University School of Medicine. Yale University School of Medicine is a one of the best medicals schools. Yale University School of Medicine is ranked 7/57 in Research/PrimaryCare. He received awards:"Elected Member". Marc K. Hellerstein is a published doctor. He has 102 papers published. The most current publication "Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans."
Publications
- Isocaloric manipulation of macronutrients Within a high-carbohydrate/moderate-fat diet induces unique effects on hepatic lipogenesis, steatosis and liver injury.
- Continuous Antigenic Stimulation of DO11.10 TCR Transgenic Mice in the Presence or Absence of IL-1β: Possible Implications for Mechanisms of T Cell Depletion in HIV Di...
- Reduced in vivo hepatic proteome replacement rates but not cell proliferation rates predict maximum lifespan extension in mice.
- PPARα inhibition modulates multiple reprogrammed metabolic pathways in kidney cancer and attenuates tumor growth.
- Potential Mechanisms Leading to the Abnormal Lipid Profile in Patients With Rheumatoid Arthritis Versus Healthy Volunteers and Reversal by Tofacitinib.
- Kinetics of Precursor Labeling in Stable Isotope Labeling in Cell Cultures (SILAC) Experiments.
- Treatment of diabetic rats With insulin or a synthetic insulin receptor agonist peptide leads to divergent metabolic responses.
- Total body skeletal muscle mass: estimation by creatine (methyl-d3) dilution in humans.
- You are what you eat: fatty acid profiles as a method to track the habitat movement of an insect.
- Greater muscle protein synthesis and mitochondrial biogenesis in males compared With females during sprint interval training.
- Reverse cholesterol transport fluxes.
- Inhibition of intestinal cholesterol absorption With ezetimibe increases components of reverse cholesterol transport in humans.
- Calorie restriction does not increase short-term or long-term protein synthesis.
- Mass spectrometry imaging for in situ kinetic histochemistry.
- Dexamethasone-Mediated Changes in Adipose Triacylglycerol Metabolism Are Exaggerated, Not Diminished, in the Absence of a Functional GR Dimerization Domain.
- Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance.
- Large increases in adipose triacylglycerol flux in Cushingoid CRH-Tg mice are explained by futile cycling.
- Regional Cell Proliferation in Microdissected Human Prostate Specimens after Heavy Water Labeling In Vivo: Correlation With Prostate Epithelial Cells Isolated from Sem...
- In Vivo Adipogenesis in Rats Measured by Cell Kinetics in Adipocytes and Plastic-Adherent Stroma-Vascular Cells in Response to High-Fat Diet and Thiazolidinedione.
- Intra-clonal complexity in chronic lymphocytic leukemia: fractions enriched in recently born/divided and older/quiescent cells.
- Measurement of human plasma proteome dynamics With (2)H(2)O and liquid chromatography tandem mass spectrometry.
- Desnutrin/ATGL Is Regulated by AMPK and Is Required for a Brown Adipose PhenoType.
- Long-term synthesis rates of skeletal muscle DNA and protein are higher during aerobic training in older humans than in sedentary young subjects but are not altered by...
- Deuterium and neutrophil kinetics.
- The effects of physiological adaptations to calorie restriction on global cell proliferation rates.
- A dual sugar challenge test for lipogenic sensitivity to dietary fructose.
- Cholecystokinin is up-regulated in obese mouse islets and expands beta-cell mass by increasing beta-cell survival.
- Differential in vivo effects on target pathways of a novel arylpyrazole glucocorticoid receptor modulator compared With prednisolone.
- Improvements in body fat distribution and circulating adiponectin by alternate-day fasting versus calorie restriction.
- Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates.
- In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia.
- Modified alternate-day fasting and cardioprotection: relation to adipose tissue dynamics and dietary fat intake.
- Consuming fructose-sweetened, not glucose-sweetened, beverages increases visceral adiposity and lipids and decreases insulin sensitivity in overweight/obese humans.
- Alternate-day fasting reduces global cell proliferation rates independently of dietary fat content in mice.
- Adipose overexpression of desnutrin promotes fatty acid use and attenuates diet-induced obesity.
- AdPLA ablation increases lipolysis and prevents obesity induced by high-fat feeding or leptin deficiency.
- A pilot study of the effects of pioglitazone and rosiglitazone on de novo lipogenesis in type 2 Diabetes.
- Centrosomal PKCbetaII and pericentrin are critical for human prostate cancer growth and angiogenesis.
- Central memory CD8+ T cells appear to have a shorter lifespan and reduced abundance as a function of HIV disease progression.
- Do calorie restriction or alternate-day fasting regimens modulate adipose tissue physiology in a way that reduces chronic disease risk?
- A gene expression network model of type 2 Diabetes links cell cycle regulation in islets with Diabetes susceptibility.
- The effect of dietary carbohydrate on genes for fatty acid synthase and inflammatory cytokines in adipose tissues from lean and obese subjects.
- Exploiting complexity and the robustness of network architecture for drug discovery.
- Measurement of pancreatic islet cell proliferation by heavy water labeling.
- Measurement of brain microglial proliferation rates in vivo in response to neuroinflammatory stimuli: application to drug discovery.
- Stabilization of hyperdynamic microtubules is neuroprotective in amyotrophic lateral sclerosis.
- Dose effects of modified alternate-day fasting regimens on in vivo cell proliferation and plasma insulin-like growth factor-1 in mice.
- Alternate-day fasting and chronic disease prevention: a review of human and animal trials.
- Measurement of liver collagen synthesis by heavy water labeling: effects of profibrotic toxicants and antifibrotic interventions.
- Whole-body glycolysis measured by the deuterated-glucose disposal test correlates highly With insulin resistance in vivo.
- Discovery of novel hippocampal neurogenic agents by using an in vivo stable isotope labeling technique.
- Measurement of mouse vascular smooth muscle and atheroma cell proliferation by 2H2O incorporation into DNA.
- Delayed secretory pathway contributions to VLDL-triglycerides from plasma NEFA, diet, and de novo lipogenesis in humans.
- Thematic review series: patient-oriented research. Recent advances in liver triacylglycerol and fatty acid metabolism using stable isotope labeling techniques.
- Heavy water labeling of keratin as a non-invasive biomarker of skin turnover in vivo in rodents and humans.
- Physiologic and pharmacologic factors influencing glyceroneogenic contribution to triacylglyceride glycerol measured by mass isotopomer distribution analysis.
- In vivo measurement of DNA synthesis rates of colon epithelial cells in carcinogenesis.
- Effects of caloric restriction on cell proliferation in several tissues in mice: role of intermittent feeding.
- In vivo measurements document the dynamic cellular kinetics of chronic lymphocytic leukemia B cells.
- In vivo measurement of microtubule dynamics using stable isotope labeling With heavy water. Effect of taxanes.
- Dynamics of keratinocytes in vivo using HO labeling: a sensitive marker of epidermal proliferation state.
- Effect of nucleoside reverse transcriptase inhibitors on mitochondrial DNA synthesis in rats and humans.
- Isolation of nuclei from label-retaining cells and measurement of their turnover rates in rat colon.
- New stable isotope-mass spectrometric techniques for measuring fluxes through intact metabolic pathways in mammalian systems: introduction of moving pictures into func...
- Subpopulations of long-lived and short-lived T cells in advanced HIV-1 infection.
- Measurement of mitochondrial DNA synthesis in vivo using a stable isotope-mass spectrometric technique.
- In vivo measurement of fluxes through metabolic pathways: the missing link in functional genomics and pharmaceutical research.
- Turnover of adipose components and mitochondrial DNA in humans: kinetic biomarkers for human immunodeficiency virus-associated lipodystrophy and mitochondrial toxicity?
- CD4+ T cell kinetics and activation in human immunodeficiency virus-infected patients who remain viremic despite long-term treatment With protease inhibitor-based ther...
- Increased lipogenesis and resistance of lipoproteins to oxidative modification in two patients with glycogen storage disease Type 1a.
- Metabolic Complications of HIV and AIDS.
- Fibroblast growth factor 21 is not required for the reductions in circulating insulin-like growth factor-1 or global cell proliferation rates in response to moderate c...
- Consumption of clarified grapefruit juice ameliorates high-fat diet induced insulin resistance and weight gain in mice.
- Adipose Weight Gain during Chronic Insulin Treatment of Mice Results from Changes in Lipid Storage Without Affecting De Novo Synthesis of Palmitate.
- Time course and dynamics of adipose tissue development in obese and lean Zucker rat pups.
- Nutrition support in clinical practice: review of published data and recommendations for future research directions.
- Measuring synthesis rates of muscle creatine kinase and myosin With stable isotopes and mass spectrometry.
- Effect of ibuprofen and acetaminophen on postexercise muscle protein synthesis.
- Is in vivo nuclear magnetic resonance spectroscopy currently a quantitative method for whole-body carbohydrate metabolism?
- Nutrition support in clinical practice: review of published data and recommendations for future research directions. Summary of a conference sponsored by the National ...
- Monitoring changes in fat-free mass in HIV-positive men With hypotestosteronemia and AIDS wasting syndrome treated With gonadal hormone replacement therapy.
- Effects of nandrolone decanoate therapy in borderline hypogonadal men With HIV-associated weight loss.
- Factors influencing T-cell turnover in HIV-1-seropositive patients.
- Methods for measuring polymerisation biosynthesis: three general solutions to the problem of the "true precursor".
- The etiology of wasting in the human immunodeficiency virus and acquired immunodeficiency syndrome.
- Directly measured kinetics of circulating T lymphocytes in normal and HIV-1-infected humans.
- Antimitotic peptide characterized from soybean: role in protection from cancer?
- Divergent tolerance to metabolic and cardiovascular effects of nicotine in smokers With low and high levels of cigarette consumption.
- Human fatty acid synthesis is stimulated by a eucaloric low fat, high carbohydrate diet.
- Influence of pravastatin on hepatic metabolism of cholesterol.
- Nutrition support in clinical practice: review of published data and recommendations for future research directions. National Institutes of Health, American Society fo...
- Altered fluxes responsible for reduced hepatic glucose production and gluconeogenesis by exogenous glucose in rats.
- Measurement of hepatic Ra UDP-glucose in vivo in rats: relation to glycogen deposition and labeling patterns.
- Regulation of hepatic de novo lipogenesis in humans.
- Synthesis of fat in response to alterations in diet: insights from new stable isotope methodologies.
- Short-term alterations in carbohydrate energy intake in humans. Striking effects on hepatic glucose production, de novo lipogenesis, lipolysis, and whole-body fuel sel...
- Effects of recombinant monokines on hepatic pyruvate dehydrogenase, pyruvate dehydrogenase kinase, lipogenesis de novo and plasma triacylglycerols. Abolition by prior ...
- Mechanisms of fructose-induced hypertriglyceridaemia in the rat. Activation of hepatic pyruvate dehydrogenase through inhibition of pyruvate dehydrogenase kinase.
- Mass isotopomer distribution analysis: a technique for measuring biosynthesis and turnover of polymers.
- Effects of dietary n-3 fatty acid supplementation in men With weight loss associated With the acquired immune deficiency syndrome: Relation to indices of cytokine prod...
- Differences in in vivo cellular kinetics in abdominal and femoral subcutaneous adipose tissue in women.
Schools
Yale University
University Vt Mc Hospital
Tufts University
Conditions Treated
- Diabetes Type 2
- Diabetes With Renal Manifestations
Doctors Specialties
- Endocrinology
Accepted Insurances
Awards
- Elected Member
Education
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Tufts Medical Center -
University of Vermont - Fletcher Allen Health Care -
Yale University School of Medicine
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