Professor, Medicine, Stony Brook University SOM
Internal Medicine
Dr. Lina M. Obeid, MD
Lina M. Obeid, MD practices Internal Medicine. Dr. Lina M. Obeid has written publications. She has 102 publications published with PubMed. The lastest paper is: 'Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.'
Publications
- Intracellular sphingosine kinase 2-derived sphingosine-1-phosphate mediates epidermal growth factor-induced ezrin-radixin-moesin phosphorylation and cancer cell invasion.
- Structural Basis for Ceramide Recognition and Hydrolysis by Human Neutral Ceramidase.
- A novel role of sphingosine kinase-1 in the invasion and angiogenesis of VHL mutant clear cell renal cell carcinoma.
- Critical determinants of mitochondria-associated neutral sphingomyelinase (MA-nSMase) for mitochondrial localization.
- Evolving concepts in cancer therapy through targeting sphingolipid metabolism.
- Sustained PKCβII activity confers oncogenic properties in a phospholipase D- and mTOR-dependent manner.
- Impact of sphingosine kinase 2 deficiency on the development of TNF-alpha-induced inflammatory arthritis.
- Sphingosine Kinase 1 Regulates Tumor Necrosis Factor-mediated RANTES Induction through p38 Mitogen-activated Protein Kinase but Independently of Nuclear Factor κB Acti...
- Sphingolipid regulation of ezrin, radixin, and moesin proteins family: Implications for cell dynamics.
- Sphingosine-1-phosphate receptor 2.
- Epidermal growth factor-induced cellular invasion requires sphingosine-1-phosphate/sphingosine-1-phosphate 2 receptor-mediated ezrin activation.
- Effect of sphingosine kinase 1 inhibition on blood pressure.
- Sphingosine 1-phosphate induces filopodia formation through S1PR2 activation of ERM proteins.
- Inhibition of sphingosine kinase-2 in a murine model of lupus nephritis.
- Sphingosine kinase 1 in cancer.
- Loss of neutral ceramidase increases inflammation in a mouse model of inflammatory bowel disease.
- Targeting the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway in Disease: Review of Sphingosine Kinase Inhibitors.
- Communication between host organism and cancer cells is transduced by systemic sphingosine kinase 1/sphingosine 1-phosphate signalling to regulate tumour metastasis.
- Cell density-dependent reduction of dihydroceramide desaturase activity in neuroblastoma cells.
- Phospholipase C and Protein Kinase C-{beta} 2 Mediate Insulin-Like Growth Factor II-Dependent Sphingosine Kinase 1 Activation.
- CERT depletion predicts chemotherapy benefit and mediates cytotoxic and polyploid-specific cancer cell death through autophagy induction.
- A dihydroceramide-based response to hypoxia.
- Impact of Sphingosine Kinase on Inflammatory Pathways in Fibroblast-Like Synoviocytes.
- Ceramide and Apoptosis: Exploring the Enigmatic Connections Between Sphingolipid Metabolism and Programmed Cell Death.
- Many Ceramides.
- Novel pathway of ceramide production in mitochondria: Thioesterase and neutral ceramidase produce ceramide from sphingosine and acyl-COA.
- Sphingosine-1-phosphate acting via the S1P(1) receptor is a downstream signaling pathway in ceramide-induced hyperalgesia.
- Intraplantar-injected ceramide in rats induces hyperalgesia through an NF-{kappa}B- and p38 kinase-dependent cyclooxygenase 2/prostaglandin E2 pathway.
- Ceramide Synthase-dependent Ceramide Generation and Programmed Cell Death: INVOLVEMENT OF SALVAGE PATHWAY IN REGULATING POSTMITOCHONDRIAL EVENTS.
- Identification of Dihydroceramide Desaturase as a Direct in vitro target for Fenretinide.
- A deficiency of ceramide biosynthesis causes cerebellar purkinje cell neurodegeneration and lipofuscin accumulation.
- Sphingosine kinase-1 and sphingosine 1-phosphate receptor 2 mediate Bcr-Abl1 stability and drug resistance by modulation of protein phosphatase 2A.
- Regulation of CC ligand 5/RANTES by acid sphingomyelinase and acid ceramidase.
- A role of sphingosine kinase 1 in head and neck carcinogenesis.
- Developmentally regulated ceramide synthase 6 increases mitochondrial Ca2+ loading capacity and promotes apoptosis.
- Mitochondrially targeted ceramides preferentially promote autophagy, retard cell growth, and induce apoptosis.
- Accumulation of Long-Chain Glycosphingolipids during Aging Is Prevented by Caloric Restriction.
- Selective knockdown of ceramide synthases reveals complex interregulation of sphingolipid metabolism.
- Differential effects of ceramide and sphingosine 1-phosphate on ERM phosphorylation: probing sphingolipid signaling at the outer plasma membrane.
- Alkaline ceramidase 2 (ACER2) and its product dihydrosphingosine mediate the cytotoxicity of N-(4-hydroxyphenyl)retinamide in tumor cells.
- Genetic sphingosine kinase 1 deficiency significantly decreases synovial inflammation and joint erosions in murine TNF-alpha-induced arthritis.
- Role of sphingosine kinase-1 in paracrine/transcellular angiogenesis and lymphangiogenesis in vitro.
- Role of alkaline ceramidases in the generation of sphingosine and its phosphate in erythrocytes.
- Sphingosine 1-phosphate and sphingosine kinase are involved in a novel signaling pathway leading to acrosomal exocytosis.
- The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.
- Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2).
- Alkaline ceramidase 3 (ACER3) hydrolyzes unsaturated long-chain ceramides, and its down-regulation inhibits both cell proliferation and apoptosis.
- An overview of sphingolipid metabolism: from synthesis to breakdown.
- AMPK inhibitor Compound C stimulates ceramide production and promotes Bax redistribution and apoptosis in MCF7 breast carcinoma cells.
- Acid beta-glucosidase 1 counteracts p38delta-dependent induction of interleukin-6: possible role for ceramide as an anti-inflammatory lipid.
- Involvement of acid beta-glucosidase 1 in the salvage pathway of ceramide formation.
- ISC1-dependent metabolic adaptation reveals an indispensable role for mitochondria in induction of nuclear genes during the diauxic shift in Saccharomyces cerevisiae.
- Role for sphingosine kinase 1 in colon carcinogenesis.
- Alkaline ceramidase 2 regulates beta1 integrin maturation and cell adhesion.
- A role for sphingosine kinase 1 in dextran sulfate sodium-induced colitis.
- Ceramide generated by sphingomyelin hydrolysis and the salvage pathway is involved in hypoxia/reoxygenation-induced Bax redistribution to mitochondria in NT-2 cells.
- Long-chain ceramide is a potent inhibitor of the mitochondrial permeability transition pore.
- De novo N-palmitoylsphingosine synthesis is the major biochemical mechanism of ceramide accumulation following p53 up-regulation.
- Hyaluronan constitutively regulates activation of COX-2-mediated cell survival activity in intestinal epithelial and colon carcinoma cells.
- Dual and distinct roles for sphingosine kinase 1 and sphingosine 1 phosphate in the response to inflammatory stimuli in RAW macrophages.
- Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2.
- Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes.
- A novel role for protein kinase Cdelta-mediated phosphorylation of acid sphingomyelinase in UV light-induced mitochondrial injury.
- The insulin-like growth factor type 1 and insulin-like growth factor type 2/mannose-6-phosphate receptors independently regulate ERK1/2 activity in HEK293 cells.
- The functional effects of acid ceramidase overexpression in prostate cancer progression and resistance to chemotherapy.
- JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction.
- The localization and activity of sphingosine kinase 1 are coordinately regulated with actin cytoskeletal dynamics in macrophages.
- Involvement of dihydroceramide desaturase in cell cycle progression in human neuroblastoma cells.
- Activation of sphingosine-1-phosphate receptor S1P5 inhibits oligodendrocyte progenitor migration.
- Alterations of ceramide/sphingosine 1-phosphate rheostat involved in the regulation of resistance to imatinib-induced apoptosis in K562 human chronic myeloid leukemia ...
- Combination of C(17) sphingoid base homologues and mass spectrometry analysis as a new approach to study sphingolipid metabolism.
- Protein kinase C-induced activation of a ceramide/protein phosphatase 1 pathway leading to dephosphorylation of p38 MAPK.
- Necessary role for the Lag1p motif in (dihydro)ceramide synthase activity.
- Insulin-like growth factors mediate heterotrimeric G protein-dependent ERK1/2 activation by transactivating sphingosine 1-phosphate receptors.
- Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P.
- Acid ceramidase but not acid sphingomyelinase is required for tumor necrosis factor-{alpha}-induced PGE2 production.
- Potent antitumor activity of a novel cationic pyridinium-ceramide alone or in combination with gemcitabine against human head and neck squamous cell carcinomas in vitr...
- Cationic long-chain ceramide LCL-30 induces cell death by mitochondrial targeting in SW403 cells.
- Differentiation-associated expression of ceramidase isoforms in cultured keratinocytes and epidermis.
- Modulation of total Akt kinase by increased expression of a single isoform: requirement of the sphingosine-1-phosphate receptor, Edg3/S1P3, for the VEGF-dependent expr...
- Loss of sphingosine kinase-1 activates the intrinsic pathway of programmed cell death: modulation of sphingolipid levels and the induction of apoptosis.
- Oxidized LDL immune complexes induce release of sphingosine kinase in human U937 monocytic cells.
- Sphingosine kinase 1 is up-regulated in colon carcinogenesis.
- The mechanism of membrane targeting of human sphingosine kinase 1.
- Immunohistochemical distribution of sphingosine kinase 1 in normal and tumor lung tissue.
- The coordination of prostaglandin E2 production by sphingosine-1-phosphate and ceramide-1-phosphate.
- Tumor necrosis factor induces the loss of sphingosine kinase-1 by a cathepsin B-dependent mechanism.
- Positively charged ceramide is a potent inducer of mitochondrial permeabilization.
- Sphingosine kinase 1 (SK1) is recruited to nascent phagosomes in human macrophages: inhibition of SK1 translocation by Mycobacterium tuberculosis.
- Golgi fragmentation is associated with ceramide-induced cellular effects.
- Inhibition of growth and telomerase activity by novel cationic ceramide analogs with high solubility in human head and neck squamous cell carcinoma cells.
- Sphingosine-1-phosphate signaling promotes critical migratory events in vasculogenesis.
- Defects in cell growth regulation by C18:0-ceramide and longevity assurance gene 1 in human head and neck squamous cell carcinomas.
- Role for mammalian neutral sphingomyelinase 2 in confluence-induced growth arrest of MCF7 cells.
- Down-regulation of sphingosine kinase-1 by DNA damage: dependence on proteases and p53.
- Rapid shortening of telomere length in response to ceramide involves the inhibition of telomere binding activity of nuclear glyceraldehyde-3-phosphate dehydrogenase.
- Involvement of endogenous ceramide in the inhibition of telomerase activity and induction of morphologic differentiation in response to all-trans-retinoic acid in huma...
- Ceramide, stress, and a "LAG" in aging.
- Role of human sphingosine-1-phosphate phosphatase 1 in the regulation of intra- and extracellular sphingosine-1-phosphate levels and cell viability.
- Cloning and characterization of a mouse endoplasmic reticulum alkaline ceramidase: an enzyme that preferentially regulates metabolism of very long chain ceramides.
- Loss of neutral ceramidase protects cells from nutrient- and energy -deprivation-induced cell death.
Doctors Specialties
- Internal Medicine
Accepted Insurances
Education
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Duke University Hospital -
American University of Beirut Faculty of Medicine
Hospital
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Stony Brook University Medical Center -
Duke University Hospital
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