Associate Professor, Internal Medicine, University of Kentucky College of Medicine

Internal Medicine

Leigh Callahan works in the field of Internal Medicine. She graduated from Medical College of Georgia. Doctor Leigh A. Callahan, MD is a published doctor. She has 22 papers published. The most current publication "Muscle-Specific Calpastatin Overexpression Prevents Diaphragm Weakness in Cecal Ligation Puncture Induced Sepsis."

Publications

---

• Muscle-Specific Calpastatin Overexpression Prevents Diaphragm Weakness in Cecal Ligation Puncture Induced Sepsis.
• β-Hydroxy-β-methylbutyrate (HMB) prevents sepsis-induced diaphragm dysfunction in mice.
• Prevention and Treatment of ICU-Acquired Weakness: Is There a Stimulating Answer?*.
• Increased myocardial short-range forces in a rodent model of diabetes reflect elevated content of β myosin heavy chain.
• Rapid and Complete Recovery in Ventilator Induced Diaphragm Weakness - Problem Solved?
• p38 Mitogen-activated protein kinase modulates endotoxin-induced diaphragm caspase activation.
• Calpain activation contributes to endotoxin-induced diaphragmatic dysfunction.
• Sepsis-induced myopathy.
• The JNK MAP kinase pathway contributes to the development of endotoxin-induced diaphragm caspase activation.
• Invited editorial on "acquired Respiratory muscle weakness in critically ill patients: what is the role of mechanical ventilation-induced diaphragm dysfunction?&q...
• Free radical-mediated skeletal muscle dysfunction in inflammatory conditions.
• The extrinsic caspase pathway modulates endotoxin-induced diaphragm contractile dysfunction.
• Diaphragm and cardiac mitochondrial creatine kinases are impaired in sepsis.
• Polyethylene glycol-superoxide dismutase prevents endotoxin-induced cardiac dysfunction.
• Caspase activation contributes to endotoxin-induced diaphragm weakness.
• Hemin prevents cardiac and diaphragm mitochondrial dysfunction in sepsis.
• Sepsis induces diaphragm electron transport chain dysfunction and protein depletion.
• Downregulation of diaphragm electron transport chain and glycolytic enzyme gene expression in sepsis.
• Diaphragmatic free radical generation increases in an animal model of Heart failure.
• CardioPulmonary responses to exercise in women with sickle cell anemia.
• Hyperglycemia and acquired weakness in critically ill patients: potential mechanisms.

Schools

---

• Medical College of Georgia

Procedures Preformed

---

• Bronchoscopy
• Thoracentesis
• Ventilation Management

Conditions Treated

---

• Acidosis
• Alkalosis
• Asthma
• Atelectasis
• View All

Doctors Specialties

---

• Critical Care Medicine
• Pulmonology
• Internal Medicine

Accepted Insurances

---

Education

---

• Medical College of Georgia
• Medical College of Georgia School of Medicine

Hospital

---

• University of Kentucky Albert B. Chandler Hospital

Helpful Reviews

---

Give Anonymous Review

Similar Doctors

---

	Dr. Samer A. Kseibi, MD This Doctor is OpenDoctor Recommended.
	Dr. Robert T. Davis, MD
	Dr. Subir K. Ghosh, MD This Doctor is OpenDoctor Recommended.
	Dr. John M. Harrison, MD This Doctor is OpenDoctor Recommended.
	Dr. Paul Mandelstam, MD This Doctor is OpenDoctor Recommended. This doctor has more publications
	Dr. Grant H. Breazeale, MD This Doctor is OpenDoctor Recommended.
	Dr. Theodore N. Guiglia, MD This Doctor is OpenDoctor Recommended.
	Dr. Christopher M. Yost, MD This Doctor is OpenDoctor Recommended.
	Dr. Lynnell C. Dupont, MD
	Dr. Dan E. Calleja, MD This Doctor is OpenDoctor Recommended.
	Dr. Ezzat El-Bayoumi, MD This Doctor is OpenDoctor Recommended.
	Dr. Matthew M. McIntosh, MD This Doctor is OpenDoctor Recommended.
	Dr. Edward A. Hirschowitz, MD This Doctor is OpenDoctor Recommended.
	Dr. Theresa V. Case, DO
	Dr. Maria G. Tupayachi Ortiz, MD This Doctor is OpenDoctor Recommended.

---

Doctor Directory | TOS | twitter | FB | Angel | blog