Chief of Cardiology Professor of Medicine
Cardiology
Dr. Kirk U. Knowlton, MD
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Kirk Knowlton practices Cardiology. He went to University of Utah School of Medicine. He over the years received 3 awards: "CMS Meaningful Use Stage 1 Certification", "Elected Member" and "Fellow (FACC)". Kirk Knowlton is also a published physician. He has 60 paper published. The most recent paper is: Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff? He accepts Medicare payments and is registered with Medicare.gov.
Publications
- Hypermorphic mutation of the voltage-gated sodium channel encoding gene Scn10a causes a dramatic stimulus-dependent neurobehavioral phenotype.
- Absence of SOCS3 in the Cardiomyocyte Increases Mortality in a gp130-Dependent Manner Accompanied by Contractile Dysfunction and Ventricular Arrhythmias.
- Loss of enigma homolog protein results in dilated Cardiomyopathy.
- Viral myocarditis: from the perspective of the virus.
- Viral myocarditis: is infection of the Heart required?
- Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine Heart.
- Antiviral and myocyte protective effects of murine interferon-beta and -{alpha}2 in coxsackievirus B3-induced myocarditis and epicarditis in Balb/c mice.
- Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated Cardiomyopathy.
- Innate defense mechanism against virus infection within the cardiac myocyte requiring gp130-STAT3 signaling.
- alpha-E-catenin inactivation disrupts the cardiomyocyte adherens junction, resulting in Cardiomyopathy and susceptibility to wall rupture.
- Prion-induced amyloid Heart disease with high blood infectivity in transgenic mice.
- Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle.
- Highlights of the year in JACC 2004.
- Interleukin-10: biomarker or pathologic cytokine in fulminant myocarditis?
- Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection.
- Preoperative partitioning of pulmonary vascular resistance correlates with early outcome after thromboendarterectomy for Chronic thromboembolic pulmonary hypertension.
- Highlights of the year in JACC 2003.
- Electrocardiographic manifestations: wide complex tachycardia due to accessory pathway.
- The suppressor of cytokine signaling-1 (SOCS1) is a novel therapeutic target for enterovirus-induced cardiac injury.
- Dystrophin deficiency markedly increases enterovirus-induced cardiomyopathy: a genetic predisposition to viral Heart disease.
- Catheter-directed neodymium:YAG laser injury of the left ventricle for arrhythmia ablation: dosimetry and hemodynamic, hematologic, and electrophysiologic effects.
- Two brothers with unexplained cardiomegaly Initial clues to the molecular basis of a hereditary cardiac Disease.
- Peripartum vascular collapse Dissection of a genetic disease.
- The immune response following Myocardial infarction: a role for T-cell-mediated myocyte damage.
- Adrenergic control of circulating lymphocyte subpopulations. Effects of congestive Heart failure, dynamic exercise, and terbutaline treatment.
- Alpha 1-adrenergic stimulation inhibits 3,5,3'-triiodothyronine-induced expression of the rat Heart sarcoplasmic reticulum Ca2+ adenosine triphosphatase gene.
- Regulated expression of a contractile protein gene correlates with recovery of contractile function after reversible metabolic inhibition in cultured myocytes.
- The immune system in viral myocarditis: maintaining the balance.
- NF-kappaB-mediated inhibition of apoptosis is required for encephalomyocarditis virus virulence: a mechanism of resistance in p50 knockout mice.
- Inflammatory pathways and cardiac repair: the affliction of Infarction.
- CVB infection and mechanisms of viral Cardiomyopathy.
- Transcriptional regulation during cardiac growth and development.
- Unsolved medical issues and new targets for further research in viral myocarditis and dilated Cardiomyopathy.
- Cardiovascular molecular biology. Introduction to the series.
- Treatment of coxsackievirus-B3-infected BALB/c mice with the soluble coxsackie adenovirus receptor CAR4/7 aggravates cardiac injury.
- Cleavage of Poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: another mechanism for host protein synthesis shutoff?
- Regulation of cardiac gene expression during Myocardial growth and hypertrophy: molecular studies of an adaptive physiologic response.
- Cardioselective infection with coxsackievirus B3 requires intact type I interferon signaling: implications for mortality and early viral replication.
- Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by Coxsackievirus 2A protease.
- Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium.
- A mutation in the puff region of VP2 attenuates the myocarditic phenotype of an infectious cDNA of the Woodruff variant of coxsackievirus B3.
- The alpha 1A-adrenergic receptor subtype mediates biochemical, molecular, and morphologic features of cultured Myocardial cell hypertrophy.
- Gq- and ras-dependent pathways mediate hypertrophy of neonatal rat ventricular myocytes following alpha 1-adrenergic stimulation.
- Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired Cardiomyopathy.
- Enteroviral Cardiomyopathy: bad news for the dystrophin-glycoprotein complex.
- Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue.
- Low-level expression of a mutant coxsackieviral cDNA induces a myocytopathic effect in culture: an approach to the study of enteroviral persistence in cardiac myocytes.
- Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for my...
- Segregation of Atrial-specific and inducible expression of an Atrial natriuretic factor transgene in an in vivo murine model of cardiac hypertrophy.
- Endothelin induction of inositol phospholipid hydrolysis, sarcomere assembly, and cardiac gene expression in ventricular myocytes. A paracrine mechanism for Myocardial...
- Co-regulation of the Atrial natriuretic factor and cardiac myosin light chain-2 genes during alpha-adrenergic stimulation of neonatal rat ventricular cells. Identifica...
- Transgenic expression of replication-restricted enteroviral genomes in Heart muscle induces defective excitation-contraction coupling and dilated cardiomyopathy.
- Nitric oxide inhibits dystrophin proteolysis by coxsackieviral protease 2A through S-nitrosylation: A protective mechanism against enteroviral Cardiomyopathy.
- Dissociation of sarcoglycans and the dystrophin carboxyl terminus from the sarcolemma in enteroviral Cardiomyopathy.
- Apoptosis and oncosis in the early progression of left ventricular dysfunction in the cardiomyopathic hamster.
- Dystrophin disruption in enterovirus-induced myocarditis and dilated Cardiomyopathy: from bench to bedside.
- Long-term cardiac gene expression using a coxsackieviral vector.
- Selective deletion of long but not short Cypher isoforms leads to late-onset dilated Cardiomyopathy.
- Cardiac-Specific Deletion of SOCS-3 Prevents Development of Left Ventricular Remodeling After Acute Myocardial Infarction.
Schools
University Of Utah School Of Medicine
Duke University Med Center
University Of California San Diego
Procedures Preformed
- Cardiac Catheterization (incl. Coronary Angiography)
- Cardiac Imaging
- Cardiac Myocardial Perfusion Imaging
- Cardioversion, Elective
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Conditions Treated
- Aneurysm and Dissection of Heart
- Angina and Acute Coronary Syndrome
- Aortic Aneurysm
- Aortic Dissection
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Doctors Specialties
- Cardiology
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- American Republic
- Amerigroup (Wellpoint)
- Blue Card PPO
- Blue Cross Blue Shield of California PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Commercial Insurance Company
- Coventry Health Care
- Federal Employee Program (FEP)
- Medicare Advantage PFFS
- Humana
- Kaiser Permanente
- Medicaid
- Medicare MCR
- Medico
- Molina
- Kaiser PHCS Network PPO
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
- United Healthcare
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
- Fellow (FACC)
Education
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Duke University Hospital -
University of California San Diego -
University of Utah School of Medicine
Hospital
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UC San Diego Health
Drug Facts
| NPI NUMBER | 1376591339 | |
| NPPES Provider LastName | KNOWLTON | |
| NPPES Provider FirstName | KIRK | |
| NPPES Provider ZIPCode | 921039000 | |
| NPPES Provider State | CA | |
| Specialty Description | Cardiology | |
| Total Claim Count | 475.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1376591339 |
| Last Name Of The Provider | KNOWLTON |
| First Name Of The Provider | KIRK |
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