Professor, Pediatrics, Baylor College of Medicine

Pediatric Endocrinology

Doctor Kenneth Gabbay, MD works in the field of Pediatric Endocrinology. He graduated from University of Rochester School of Medicine and Dentistry. He has 1 awards "Elected Member". Dr. Kenneth Gabbay is a published doctor and has 101 publications published. The lastest was: 'The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.'

Publications

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• LUNG SURFACTANTS, COUNTERIONS, AND HYSTERESIS.
• Paperchromatography of cholesterol esters.
• Cyclosporine A inhibits the adaptive responses to hypertonicity: a potential mechanism of nephrotoxicity.
• Characterization of the human aldehyde reductase gene and promoter.
• Osmotic response element enhancer activity. Regulation through p38 kinase and mitogen-activated extracellular signal-regulated kinase kinase.
• Factors affecting counteraction by methylamines of urea effects on aldose reductase.
• The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
• Linkage analyses in type I diabetes mellitus using CASPAR, a software and statistical program for conditional analysis of polygenic diseases.
• Identification and characterization of multiple osmotic response sequences in the human aldose reductase gene.
• Analysis of candidate genes for susceptibility to type I diabetes: a case-control and family-association study of genes on chromosome 2q31-35.
• Characterization of an element resembling an androgen response element (ARE) in the human aldose reductase promoter.
• Characterization of a novel murine aldo-keto reductase.
• Aldehyde reductase. Catalytic mechanism and substrate recognition.
• The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity.
• Characterization of the osmotic response element of the human aldose reductase gene promoter.
• The search for IDDM susceptibility genes: the next generation.
• Cys298 is responsible for reversible thiol-induced variation in aldose reductase activity.
• Characterization of the human aldose reductase gene promoter.
• Localization of a type I diabetes susceptibility locus to the variable tandem repeat region flanking the insulin gene.
• Retinal circulatory abnormalities in type 1 diabetes.
• Tyrosine-48 is the proton donor and histidine-110 directs substrate stereochemical selectivity in the reduction reaction of human aldose reductase: enzyme kinetics and...
• An anion binding site in human aldose reductase: mechanistic implications for the binding of citrate, cacodylate, and glucose 6-phosphate.
• Mechanism of aldose reductase inhibition: binding of NADP+/NADPH and alrestatin-like inhibitors.
• Expression, crystallization and preliminary crystallographic analysis of human carbonyl reductase.
• Linkage of the VNTR/insulin-gene and type I diabetes mellitus: increased gene sharing in affected sibling pairs.
• The HOXD8 locus (2q31) is linked to type I diabetes. Interaction with chromosome 6 and 11 disease susceptibility genes.
• Mechanism of human aldehyde reductase: characterization of the active site pocket.
• Human aldose reductase: pK of tyrosine 48 reveals the preferred ionization state for catalysis and inhibition.
• Human aldose reductase: subtle effects revealed by rapid kinetic studies of the C298A mutant enzyme.
• Human aldose reductase: rate constants for a mechanism including interconversion of ternary complexes by recombinant wild-type enzyme.
• Glycosylation of variant hemoglobins in normal and diabetic subjects.
• The insulinopathies.
• Hemoglobin carbamylation in uremia.
• Human pancreatic polypeptide: studies in fasting and in the growth hormone deficient state.
• Hyperglycemia and plasma lipid levels: a prospective study of young insulin-dependent diabetic patients.
• Hyperglycemia and plasma lipid levels: covariations in insulin-dependent diabetes.
• Kinetics of an orally absorbed aldose reductase inhibitor, sorbinil.
• Umbilical cord glycosylated hemoglobin in infants of diabetic mothers: relationships to neonatal hypoglycemia, macrosomia, and cord serum C-peptide.
• Glycosylated hemoglobin and diabetes mellitus.
• Extended major histocompatibility complex haplotypes in type I diabetes mellitus.
• Muscle capillary basement-membrane thickness and long-term glycemia in type I diabetes mellitus.
• [The biochemical basis of the complications of diabetes].
• Aldose reductase inhibition improves nerve conduction velocity in diabetic patients.
• Sequence of cDNA encoding human insulin-like growth factor I precursor.
• Chemical quantitation of hemoglobin glycosylation: fluorometric detection of formaldehyde released upon periodate oxidation of glycoglobin.
• HLA antigens of insulin-dependent diabetics. I. PLT colonies detecting Dw10 and a new class II determinant distinct from HLA-D, DR, MB(DC), MT, and SB.
• Radioimmunoassay for catfish pancreatic somatostatin-22.
• Effects of E coli endotoxin on pancreatic hormones and blood flow.
• Formation of biologically active peptides.
• Isolation and characterization of immunoreactive somatostatin from fish pancreatic islets.
• Sorbitol pathway: presence in nerve and cord with substrate accumulation in diabetes.
• The effect of an aldose reductase inhibitor on the galactose-exposed rabbit lens.
• The sorbitol pathway in diabetes and galactosemia: enzyme and sobstrate localization and changes in kidney.
• Purification and immunologic identification of aldose reductases.
• Mechanism of development and possible prevention of sugar cataracts.
• Pancreatic beta-cell web: its possible role in insulin secretion.
• Purification and immunological identification of bovine retinal aldose reductase.
• Inhibition of glucose-induced release of insulin by aldose reductase inhibitors.
• The sorbitol pathway. Enzyme localization and content in normal and diabetic nerve and cord.
• Polyol accumulation in galactosemic and diabetic rats: control by an aldose reductase inhibitor.
• Role of sorbitol pathway in neuropathy.
• The sorbitol pathway and the complications of diabetes.
• Histamine release from human leukocytes: modulation by a cytochalasin B-sensitive barrier.
• Growth hormone, sorbitol, and diabetic capillary disease.
• A minor subset of HLA-DR3 haplotypes is preferentially increased in type 1 (insulin-dependent) diabetes.
• Growth hormone regulates the abundance of insulin-like growth factor I RNA in adult rat liver.
• Secretion of an insulin-like growth factor-I-related protein by human breast cancer cells.
• Primary structure of aldehyde reductase from human liver.
• T-cell-defined DR4 subtypes as markers for type 1 diabetes.
• Oligonucleotide probes for HLA-DQA and DQB genes define susceptibility to type 1 (insulin-dependent) diabetes mellitus.
• Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.
• Primary association of HLA-DQw8 with type I diabetes in DR4 patients.
• The aldo-keto reductase superfamily. cDNAs and deduced amino acid sequences of human aldehyde and aldose reductases.
• Two unrelated patients with familial hyperproinsulinemia due to a mutation substituting histidine for arginine at position 65 in the proinsulin molecule: identificatio...
• Multigenic basis for type I diabetes. Association of HRAS1 polymorphism with HLA-DR3, DQw2/DR4, DQw8.
• Effect of puberty on insulinlike growth factor I and HbA1 in type I diabetes.
• Expression of human aldose and aldehyde reductases. Site-directed mutagenesis of a critical lysine 262.
• An unlikely sugar substrate site in the 1.65 A structure of the human aldose reductase holoenzyme implicated in diabetic complications.
• Catalytic effectiveness of human aldose reductase. Critical role of C-terminal domain.
• Further identification of the nature and linkage of the carbohydrate in hemoglobin A1c.
• Aldose reductases from mammalian tissues.
• Vesicular binesis: glucose effect on insulin secretory vesicles.
• Editorial: Glycosylated hemoglobin and diabetic control.
• The biosynthesis of human hemoglobin A1c. Slow glycosylation of hemoglobin in vivo.
• Glycosylated hemoglobins and long-term blood glucose control in diabetes mellitus.
• Ultrastructural localization of pancreatic polypeptide in human pancreas.
• Familial hyperproinsulinemia. An autosomal dominant defect.
• Somatostatin and pancreatic polypeptide secretion: effects of glucagon, insulin, and arginine.
• The glycosylation of hemoglobin: relevance to diabetes mellitus.
• The infant of the diabetic mother: correlation of increased cord C-peptide levels with macrosomia and hypoglycemia.
• Structural heterogeneity of human hemoglobin A due to nonenzymatic glycosylation.
• Glycosylated hemoglobins: increased glycosylation of hemoglobin A in diabetic patients.
• Aldose reductase in retinal mural cells.
• The development and regulation of the endocrine pancreas.
• "Somatostatinoma": a somatostatin-containing tumor of the endocrine pancreas.
• Familial hyperproinsulinemia: partial characterization of circulating proinsulin-like material.
• Hyperglycemia, polyol metabolism, and complications of diabetes mellitus.
• Hypoglycemia of infancy and nesidioblastosis. Studies with somatostatin.
• Aldose reductase inhibition: studies with alrestatin.
• Genetic marker for insulin-dependent diabetes mellitus.

Schools

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• University Of Rochester

Doctors Specialties

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• Internal Medicine
• Other
• Pediatric Endocrinology

Accepted Insurances

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Awards

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• Elected Member

Education

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• Massachusetts General Hospital
• Sinai Hospital of Baltimore
• University of Rochester School of Medicine and Dentistry

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