Assistant Professor, Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Southwestern Medical School

Neurology

Doctor Juan M. Pascual, MD is an expert in the field of Neurology. Juan Pascual is a published physician. He published 83 publications, including: '[Experimental animal models in cerebral ischemia].'

Publications

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• Glucose Transporter Type I Deficiency (G1D) at 25 (1990-2015): Presumptions, Facts, and the Lives of Persons With This Rare Disease.
• Acute effect of glucose on cerebral blood flow, blood oxygenation, and oxidative metabolism.
• Triheptanoin for Glucose Transporter Type I Deficiency (G1D): Modulation of Human Ictogenesis, Cerebral Metabolic Rate, and Cognitive Indices by a Food Supplement.
• Diagnostic yield of clinical next-generation sequencing panels for Epilepsy.
• Alternating Hemiplegia of Childhood With a de Novo Mutation in ATP1A3 and Changes in SLC2A1 Responsive to a Ketogenic Diet.
• Molecular and clinical characterization of the myopathic form of mitochondrial DNA depletion syndrome caused by mutations in the thymidine kinase (TK2) gene.
• Modeling of brain metabolism and pyruvate compartmentation using (13)C NMR in vivo: caution required.
• Heptanoate as a neural fuel: energetic and neurotransmitter precursors in normal and glucose transporter I-deficient (G1D) brain.
• Cortical metabolism in pyruvate dehydrogenase deficiency revealed by ex vivo multiplet (13)C NMR of the adult mouse brain.
• Effect of hypoxia and hyperoxia on cerebral blood flow, blood oxygenation, and oxidative metabolism.
• Analysis of tumor metabolism reveals mitochondrial glucose oxidation in genetically diverse human glioblastomas in the mouse brain in vivo.
• Unsuspected stroke signals: From extravascular blood to vessel lumen.
• Metabolism of U-(13) Cglucose in human brain tumors in vivo.
• Animal models of the human mind: Is there anything like being autistic?
• High-resolution detection of (13)C multiplets from the conscious mouse brain by ex vivo NMR spectroscopy.
• Cerebral folate deficiency syndromes in childhood: clinical, analytical, and etiologic aspects.
• Measurement of glycine in the human brain in vivo by (1) H-MRS at 3 T: application in brain tumors.
• Pyruvate carboxylase deficiency: mechanisms, mimics and anaplerosis.
• Childhood chorea with cerebral hypotrophy: a treatable GLUT1 energy failure syndrome.
• Protean phenotypic features of the A3243G mitochondrial DNA mutation.
• Functional studies of the T295M mutation causing Glut1 deficiency: glucose efflux preferentially affected by T295M.
• Epilepsy in inherited metabolic disorders.
• Structural signatures and membrane helix 4 in GLUT1: inferences from human blood-brain glucose transport mutants.
• Immunophenotypic characterization and quantification of the epithelial Inflammatory infiltrate in eosinophilic esophagitis through stereology: an analysis of the cellu...
• Brain glucose supply and the syndrome of infantile neuroglycopenia.
• Nerve conduction abnormalities in patients with MELAS and the A3243G mutation.
• Glut-1 deficiency syndrome: clinical, genetic, and therapeutic aspects.
• Eosinophilic esophagitis in adults: an emerging Disease.
• Functional studies of threonine 310 mutations in Glut1: T310I is pathogenic, causing Glut1 deficiency.
• Imaging the metabolic footprint of Glut1 deficiency on the brain.
• Changes in glucose transport and water permeability resulting from the T310I pathogenic mutation in Glut1 are consistent with two transport channels per monomer.
• Glucose transporter protein syndromes.
• [Ambulatory arterial pressure and left ventricular hypertrophy in untreated hypertensive patients].
• [Insertion/deletion polymorphism of the gene encoding for angiotensin-converting enzyme and microalbuminuria in essential arterial hypertension].
• [Factors associated with changes in microalbuminuria during antihypertensive treatment].
• Penetrating ballistic-like frontal brain injury caused by a metallic rod.
• [Giant cavernous sinus haemangioma. Case report].
• Spontaneous acute hemorrhage within a subependymoma of the lateral ventricle: successful emergent surgical removal through a frontal transcortical approach.
• Zonisamide versus diazepam in the treatment of alcohol withdrawal syndrome.
• Multiple residues specify external tetraethylammonium blockade in voltage-gated potassium channels.
• Preventing misfolded neuronal protein aggregation by molecular diplomacy.
• Synaptic transporters are deceived if they think themselves free.
• Manometric findings in adult eosinophilic oesophagitis: a study of 12 cases.
• A mouse model for Glut-1 haploinsufficiency.
• [Glucose transport hereditary Diseases].
• Fever, molecular excitability and Epilepsy.
• [Progresses in studies on the glucose transporter deficiency syndrome].
• Rectal biopsy in the diagnosis of neuronal intranuclear hyaline inclusion Disease.
• GLUT1 deficiency and other glucose transporter Diseases.
• Clinical spectrum of mitochondrial DNA depletion due to mutations in the thymidine kinase 2 gene.
• Autosomal dominant glut-1 deficiency syndrome and familial Epilepsy.
• [Type 1 glucose transporter (Glut1) deficiency: manifestations of a hereditary neurological syndrome].
• State-dependent accessibility and electrostatic potential in the channel of the acetylcholine receptor. Inferences from rates of reaction of thiosulfonates with substi...
• The intrinsic electrostatic potential and the intermediate ring of charge in the acetylcholine receptor channel.
• [Neurological phenocopying].
• Nonhistological diagnosis of human cerebral tumors by 1H magnetic resonance spectroscopy and amino acid analysis.
• Intraventricular craniopharyngiomas: topographical classification and surgical approach selection based on an extensive overview.
• Natural history of MELAS associated with mitochondrial DNA m.3243A>G genotype.
• [Neonatal myasthenic syndromes].
• [Glucose transporter type 1 deficiency: a treatable neuro-metabolic disorder].
• Delimiting the binding site for quaternary ammonium lidocaine derivatives in the acetylcholine receptor channel.
• Contribution of the NH2 terminus of Kv2.1 to channel activation.
• Pattern recognition analysis of 1H NMR spectra from perchloric acid extracts of human brain tumor biopsies.
• [Cerebral palsy: prenatal risk factors].
• Glutamate, glutamine, and GABA as substrates for the neuronal and glial compartments after focal cerebral ischemia in rats.
• [Experimental animal models in cerebral ischemia].
• A novel de novo KIF21A mutation in a patient with congenital fibrosis of the extraocular muscles and Möbius syndrome.
• [The role of the extra-intracranial anastomosis and interventionist endovascular therapy in the treatment of complex cerebral aneurysms].
• Third ventricle glioblastoma. Case report and review of literature.
• Occipital air sinus causing intracerebral pneumocephalus. Case illustration.
• Functional role of a conserved aspartate in the external mouth of voltage-gated potassium channels.
• [Urinary albumin excretion during the night in essential arterial hypertension].
• [Papilloma virus infection and cancer of the cervix uteri in carriers of human immunodeficiency virus].
• [Microalbuminuria in essential arterial hypertension].
• [Nutritional changes in patients with advanced chronic obstructive pulmonary Disease].
• [Sublingual captopril in the treatment of hypertensive crises].
• [Comparative study of nosocomial Legionella pneumophila pneumonia and other microorganisms].
• [Nosocomial pneumonia caused by Legionella micdadei].
• [Legionella pneumophila pneumonia. Clinical characteristics of 52 cases].
• [Nosocomial pneumonia caused by Legionella pneumophila: a prospective study].
• [Impact of diabetes mellitus on hospitalization costs].
• [Renin-angiotensin system genetic polymorphisms and essential hypertension in the Spanish population].

Schools

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• Universidad De Granada Facultad De Medicina

Procedures Preformed

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• EEG (Electroencephalogram)

Conditions Treated

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• Ataxia
• Cerebrovascular Disease
• Convulsions
• Diplopia
• View All

Doctors Specialties

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• Pediatric Neurology
• Neurology

Accepted Insurances

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• Aetna HMO
• Choice Plus POS II
• Blue Card PPO
• Blue Choice
• Cigna HMO
• Cigna PPO
• Great West Healthcare-Cigna PPO
• LocalPlus
• Open Access Plus
• Choice Care PPO
• Preferred PPO
• PHCS Network PPO
• Choice Plus POS
• Navigate HMO
• Navigate POS
• Options PPO

Education

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• New York Presbyterian Hospital
• Washington University
• Universidad de Granada Faculty of Medicine

Hospital

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• University of Texas Southwestern Medical Center
• Children's Health System of Texas

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