Professor, Internal Medicine, University of Texas Southwestern Medical Center, Southwestern Medical School
Gastroenterology
Dr. John M. Dietschy, MD
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Doctor John M. Dietschy, MD is an expert in the field of Gastroenterology. He studied medicine at Washington University School of Medicine in St. Louis. He received awards:"Fellow (AGAF)" and "Elected Member". John M. Dietschy, MD is a published MD. He has 101 papers published. The most current publication "Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein."
Publications
- Delineation of biochemical, molecular, and physiological changes accompanying bile acid pool size restoration in Cyp7a1-/- mice fed low levels of cholic acid.
- Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment.
- Quantitative role of LAL, NPC2, and NPC1 in lysosomal cholesterol processing defined by genetic and pharmacological manipulations.
- Multiple mechanisms limit the accumulation of unesterified cholesterol in the small intestine of mice deficient in both ACAT2 and ABCA1.
- Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life.
- Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid.
- ABCA1 plays no role in the centripetal movement of cholesterol from peripheral tissues to the liver and intestine in the mouse.
- Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse.
- Inhibiting intestinal NPC1L1 activity prevents diet-induced increase in biliary cholesterol in Golden Syrian hamsters.
- GM2/GD2 and GM3 gangliosides have no effect on cellular cholesterol pools or turnover in normal or NPC1 mice.
- Genetic variations and treatments that affect the lifespan of the NPC1 mouse.
- Liver X receptor activation enhances cholesterol loss from the brain, decreases neuroinflammation, and increases survival of the NPC1 mouse.
- Receptor-mediated and bulk-phase endocytosis cause macrophage and cholesterol accumulation in Niemann-Pick C disease.
- Lysosomal unesterified cholesterol content correlates with liver cell death in murine Niemann-Pick type C disease.
- Cholesterol substrate pools and steroid hormone levels are normal in the face of mutational inactivation of NPC1 protein.
- Cholesterol accumulation and liver cell death in mice with Niemann-Pick type C disease.
- Niemann-Pick C1 expression is not regulated by the amount of cholesterol flowing through cells in the mouse.
- Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption.
- Molecular, anatomical, and biochemical events associated with neurodegeneration in mice with Niemann-Pick type C disease.
- ACAT2 deficiency limits cholesterol absorption in the cholesterol-fed mouse: impact on hepatic cholesterol homeostasis.
- Thematic review series: brain Lipids. Cholesterol metabolism in the central nervous system during early development and in the mature animal.
- Quantitation of two pathways for cholesterol excretion from the brain in normal mice and mice with neurodegeneration.
- Knockout of the cholesterol 24-hydroxylase gene in mice reveals a brain-specific mechanism of cholesterol turnover.
- The intestinal absorption of biliary and dietary cholesterol as a drug target for lowering the plasma cholesterol level.
- Inhibition of cholesterol absorption by SCH 58053 in the mouse is not mediated via changes in the expression of mRNA for ABCA1, ABCG5, or ABCG8 in the enterocyte.
- Fatty acids differentially regulate hepatic cholesteryl ester formation and incorporation into lipoproteins in the liver of the mouse.
- Control of cholesterol turnover in the mouse.
- Alternate pathways of bile acid synthesis in the cholesterol 7alpha-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding.
- Degeneration of neurons and glia in the Niemann-Pick C mouse is unrelated to the low-density lipoprotein receptor.
- Selective neurodegeneration, without neurofibrillary tangles, in a mouse model of Niemann-Pick C disease.
- Cholesterol metabolism in the brain.
- Cholesterol is sequestered in the brains of mice with Niemann-Pick type C disease but turnover is increased.
- Induction of bile acid synthesis by cholesterol and cholestyramine feeding is unimpaired in mice deficient in apolipoprotein AI.
- Is there a connection between the concentration of cholesterol circulating in plasma and the rate of neuritic plaque formation in Alzheimer disease?
- Disruption of the sterol 27-hydroxylase gene in mice results in hepatomegaly and hypertriglyceridemia. Reversal by cholic acid feeding.
- Regulation of absorption and ABC1-mediated efflux of cholesterol by RXR heterodimers.
- Centripetal cholesterol flow from the extrahepatic organs through the liver is normal in mice with mutated Niemann-Pick type C protein (NPC1).
- Cholesterol accumulation in tissues of the Niemann-pick type C mouse is determined by the rate of lipoprotein-cholesterol uptake through the coated-pit pathway in each...
- Genetic differences in cholesterol absorption in 129/Sv and C57BL/6 mice: effect on cholesterol responsiveness.
- Cholesterol balance and metabolism in mice with loss of function of Niemann-Pick C protein.
- Centripetal cholesterol flux to the liver is dictated by events in the peripheral organs and not by the plasma high density lipoprotein or apolipoprotein A-I concentra...
- Gender-related differences in bile acid and sterol metabolism in outbred CD-1 mice fed low- and high-cholesterol diets.
- Marked reduction in bile acid synthesis in cholesterol 7alpha-hydroxylase-deficient mice does not lead to diminished tissue cholesterol turnover or to hypercholesterol...
- Preferential utilization of newly synthesized cholesterol for brain growth in neonatal lambs.
- Dietary fatty acids and the regulation of plasma low density lipoprotein cholesterol concentrations.
- Identification of a metabolic difference accounting for the hyper- and hyporesponder phenotypes of cynomolgus monkey.
- Design criteria for studies examining individual fatty acid effects on cardiovascular disease risk factors: human and animal studies.
- Theoretical considerations of what regulates low-density-lipoprotein and high-density-lipoprotein cholesterol.
- Regulation of fecal bile acid excretion in male golden Syrian hamsters fed a cereal-based diet with and without added cholesterol.
- Brain does not utilize low density lipoprotein-cholesterol during fetal and neonatal development in the sheep.
- Effect of feeding psyllium and cholestyramine in combination on low density lipoprotein metabolism and fecal bile acid excretion in hamsters with dietary-induced hyper...
- Centripetal cholesterol flux from extrahepatic organs to the liver is independent of the concentration of high density lipoprotein-cholesterol in plasma.
- Apolipoprotein E competitively inhibits receptor-dependent low density lipoprotein uptake by the liver but has no effect on cholesterol absorption or synthesis in the ...
- The interaction of dietary cholesterol and specific fatty acids in the regulation of LDL receptor activity and plasma LDL-cholesterol concentrations.
- Regulation of plasma LDL-cholesterol levels by dietary cholesterol and fatty acids.
- Role of liver in the maintenance of cholesterol and low density lipoprotein homeostasis in different animal species, including humans.
- Reevaluation and application of the dual-isotope plasma ratio method for the measurement of intestinal cholesterol absorption in the hamster.
- Psyllium augments the cholesterol-lowering action of cholestyramine in hamsters by enhancing sterol loss from the liver.
- Effect of long-chain fatty acids on low-density-lipoprotein-cholesterol metabolism.
- Role of the low density lipoprotein receptor in the flux of cholesterol through the plasma and across the tissues of the mouse.
- Dietary trans fatty acids and lipoprotein cholesterol.
- Trans-9-octadecenoic acid is biologically neutral and does not regulate the low density lipoprotein receptor as the cis isomer does in the hamster.
- Regulation of hepatic cholesterol metabolism in the rat in vivo: effect of a synthetic fat-free diet on sterol synthesis and low-density lipoprotein transport.
- Role of liver in the synthesis of cholesterol and the clearance of low density lipoproteins in the cynomolgus monkey.
- Mechanisms of LDL-cholesterol lowering action of psyllium hydrophillic mucilloid in the hamster.
- Sterol metabolism in fetal, newborn, and suckled lambs and their response to cholesterol after weaning.
- The contribution of newly synthesized cholesterol to biliary cholesterol in the rat.
- Intestinal kinetic parameters: effects of unstirred layers and transport preparation.
- Permeability characteristics of muscle membrane.
- Experimental demonstration of the effect of the unstirred water layer on the kinetic constants of the membrane transport of D-glucose in rabbit jejunum.
- Rates of sterol synthesis and uptake in the major organs of the rat in vivo.
- Kinetic parameters of the lipoprotein transport systems in the adrenal gland of the rat determined in vivo. Comparison of low and high density lipoproteins of human an...
- Regulation of rates of cholesterol synthesis in vivo in the liver and carcass of the rat measured using [3H]water.
- Binding of Salmonella typhimurium lipopolysaccharides to rat high-density lipoproteins.
- Sites of tissue binding and uptake in vivo of bacterial lipopolysaccharide-high density lipoprotein complexes: studies in the rat and squirrel monkey.
- In vivo modulation of rat liver acyl-coenzyme A:cholesterol acyltransferase by phosphorylation and substrate supply.
- Alteration of the degree of biliary cholesterol saturation in the hamster and rat by manipulation of the pools of preformed and newly synthesized cholesterol.
- Sterol synthesis in vivo in 18 tissues of the squirrel monkey, guinea pig, rabbit, hamster, and rat.
- Absolute rates of cholesterol synthesis in rat intestine in vitro and in vivo: a comparison of different substrates in slices and isolated cells.
- Dual modulation of hepatic and intestinal acyl-CoA: cholesterol acyltransferase activity by (de-)phosphorylation and substrate supply in vitro.
- Relative rates of sterol synthesis in the liver and various extrahepatic tissues of normal and cholesterol-fed rabbits. Relationship to plasma lipoprotein and tissue c...
- Biological activity, lipoprotein-binding behavior, and in vivo disposition of extracted and native forms of Salmonella typhimurium lipopolysaccharides.
- Modulation of the stimulatory effect of pregnenolone-16 alpha-carbonitrile on biliary cholesterol output in the rat by manipulation of the rate of hepatic cholesterol ...
- Synthesis and coenzyme A-dependent esterification of cholesterol in rat intestinal epithelium. Differences in cellular localization and mechanisms of regulation.
- Dissociation of hepatic cholesterol synthesis from hepatic low-density lipoprotein uptake and biliary cholesterol saturation in female and male hamsters of different a...
- Measurement of rates of cholesterol synthesis using tritiated water.
- Age-related decreases in tissue sterol acquisition are mediated by changes in cholesterol synthesis and not low density lipoprotein uptake in the rat.
- Regulation of low density lipoprotein uptake and degradation in different animals species.
- Regulation of cholesterol metabolism in man and in other species.
- Quantitative importance of different organs for cholesterol synthesis and low-density-lipoprotein degradation.
- Cholesterol synthesis and low density lipoprotein uptake are regulated independently in rat small intestinal epithelium.
- Rates of receptor-dependent and -independent low density lipoprotein uptake in the hamster.
- Cholesterol synthesis in vivo and in vitro in the WHHL rabbit, an animal with defective low density lipoprotein receptors.
- Correlation of low and high density lipoprotein binding in vivo with rates of lipoprotein degradation in the rat. A comparison of lipoproteins of rat and human origin.
- Effects of clofibrate, cholestyramine, zanchol, probucol, and AOMA feeding on hepatic and intestinal cholesterol metabolism and on biliary lipid secretion in the rat.
- Effects of bile salts on intermediate metabolism of the intestinal mucosa.
- Bile acid metabolism. I. Studies on the mechanisms of intestinal transport.
- A gas-liquid chromatographic procedure for the measurement of mevalonic acid synthesis.
- Active transport of 5,5-dimethyl-2,4-oxazolidinedione.
- Cholesterol synthesis by the gastrointestinal tract: localization and mechanisms of control.
Schools
Washington Center School of Medicine
Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- Fellow (AGAF)
- Elected Member
Education
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Boston University Medical Center -
Exempla St Joseph Hospital -
Washington University School of Medicine in St. Louis
Hospital
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University of Texas Southwestern Medical Center
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