Professor Emeritus, Internal Medicine, UCSF School of Medicine
Cardiology
Dr. Joel S. Karliner, MD
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Doctor Joel S. Karliner, MD practices Cardiology. He went to Columbia University College of Physicians & Surgeons. Columbia University College of Physicians & Surgeons is a top medical university. Columbia University College of Physicians & Surgeons is ranked 8/52 in Research/PrimaryCare. Joel Karliner is a published doctor. He has 102 publications published. The most current publication "Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts."
Publications
- IL-15: A Novel Prosurvival Signaling Pathway in Cardiomyocytes.
- Arsonists and Firefighters: The Perpetual Inflammatory Civil War for Survival.
- The Immunosuppressant FTY720 Prolongs Survival in a Mouse Model of Diet-induced Coronary Atherosclerosis and Myocardial Infarction.
- Sphingolipids in cardiovascular and cerebrovascular systems: Pathological implications and potential therapeutic targets.
- Sphingosine kinase and sphingosine 1-phosphate in the Heart: A decade of progress.
- A novel intracellular isoform of matrix metalloproteinase-2 induced by oxidative stress activates innate immunity.
- S1P lyase: a novel therapeutic target for ischemia-reperfusion injury of the Heart.
- A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning.
- Altering pyrroloquinoline quinone nutritional status modulates mitochondrial, lipid, and energy metabolism in rats.
- Minocycline protects cardiac myocytes against simulated ischemia–reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1.
- High-density lipoprotein determines adult mouse cardiomyocyte fate after hypoxia-reoxygenation through lipoprotein-associated sphingosine 1-phosphate.
- Vincristine attenuates N-methyl-N'-nitro-N-nitrosoguanidine-induced poly-(ADP) ribose polymerase activity in cardiomyocytes.
- Lessons from the besotted Heart.
- Vincristine Attenuates MNNG-Induced PARP Activity in Cardiomyocytes.
- Sphingosine 1-phosphate is an important endogenous cardioprotectant released by ischemic pre- and postconditioning.
- Cardiac transgenic matrix metalloproteinase-2 expression induces myxomatous Valve degeneration: a potential model of mitral Valve prolapse disease.
- Cardiomyocyte S1P1 receptor-mediated extracellular signal-related kinase signaling and desensitization.
- Sphingolipid signaling and treatment during remodeling of the uninfarcted ventricular wall after Myocardial infarction.
- Myocardial survival signaling in response to stem cell transplantation.
- Sphingosine kinase and sphingosine 1-phosphate in cardioprotection.
- Combined sphingosine, S1P and ischemic postconditioning rescue the Heart after protracted ischemia.
- Vincristine attenuates doxorubicin cardiotoxicity.
- Sphingosine can pre- and post-condition Heart and utilizes a different mechanism from sphingosine 1-phosphate.
- Expression of a Gi-coupled receptor in the heart causes impaired Ca2+ handling, myofilament injury, and dilated Cardiomyopathy.
- Pyrroloquinoline quinone preserves mitochondrial function and prevents oxidative injury in adult rat cardiac myocytes.
- Differences among cell types in NAD(+) compartmentalization: a comparison of neurons, astrocytes, and cardiac myocytes.
- Signals from type 1 sphingosine 1-phosphate receptors enhance adult mouse cardiac myocyte survival during hypoxia.
- Redox-dependent change of nucleotide affinity to the active site of the mammalian complex I.
- Epinephrine is required for normal cardiovascular responses to stress in the phenylethanolamine N-methyltransferase knockout mouse.
- Transgenic MMP-2 expression induces latent cardiac mitochondrial dysfunction.
- Cardiac matrix metalloproteinase-2 expression independently induces marked ventricular remodeling and systolic dysfunction.
- Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat Heart.
- Cardiac ischemia-reperfusion injury induces matrix metalloproteinase-2 expression through the AP-1 components FosB and JunB.
- Toward solving the riddle: the enigma becomes less mysterious.
- Comparison of pyrroloquinoline quinone and/or metoprolol on Myocardial infarct size and mitochondrial damage in a rat model of ischemia/reperfusion injury.
- Sustained preconditioning induced by cardiac transgenesis with the tetracycline transactivator.
- MnSOD in mouse heart: Acute responses to ischemic preconditioning and ischemia-reperfusion injury.
- A rapid radioassay for sphingosine kinase.
- Pyrroloquinoline quinone (PQQ) decreases Myocardial infarct size and improves cardiac function in rat models of ischemia and ischemia/reperfusion.
- Sphingosine kinase activation mediates ischemic preconditioning in murine Heart.
- Mechanisms of cardioprotection by lysophospholipids.
- Second hand smoke stimulates tumor angiogenesis and growth.
- Protein kinase C epsilon dependence of the recovery from down-regulation of S1P1 G protein-coupled receptors of T lymphocytes.
- Moderate alcohol consumption induces sustained cardiac protection by activating PKC-epsilon and Akt.
- Cardioprotection mediated by sphingosine-1-phosphate and ganglioside GM-1 in wild-type and PKC epsilon knockout mouse Hearts.
- N-terminal truncated intracellular matrix metalloproteinase-2 induces cardiomyocyte hypertrophy, inflammation and systolic Heart failure.
- FTY720 postconditions isolated perfused Heart by a mechanism independent of sphingosine kinase 2 and different from S1P or ischemic postconditioning.
- The lysophospholipids sphingosine-1-phosphate and lysophosphatidic acid enhance survival during hypoxia in neonatal rat cardiac myocytes.
- Neonatal mouse cardiac myocytes exhibit cardioprotection induced by hypoxic and pharmacologic preconditioning and by transgenic overexpression of human Cu/Zn superoxid...
- Mechanisms of lysolipid phosphate effects on cellular survival and proliferation.
- Gelsolin binding and cellular presentation of lysophosphatidic acid.
- Endothelin-1 stimulates cardiac fibroblast proliferation through activation of protein kinase C.
- Hypoxia differentially regulates stress proteins in cultured cardiomyocytes: role of the p38 stress-activated kinase signaling cascade, and relation to cytoprotection.
- Fulminant myocarditis.
- The green fluorescent protein is an efficient biological marker for cardiac myocytes.
- United Nations Development Program solicits funds from corporations.
- Altered gene expression during hypoxia and reoxygenation of the Heart.
- Angiotensin II stimulates cardiac myocyte hypertrophy via paracrine release of TGF-beta 1 and endothelin-1 from fibroblasts.
- Expression and regulation of adhesion molecules in cardiac cells by cytokines: response to Acute hypoxia.
- A selective epsilon-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induced cell death.
- Chronic hypoxia modulates the interleukin-1beta-stimulated inducible nitric oxide synthase pathway in cardiac myocytes.
- Cross talk between angiotensin AT1 and alpha 1-adrenergic receptors: angiotensin II downregulates alpha 1a-adrenergic receptor subtype mRNA and density in neonatal rat...
- Chronic hypoxia increases beta 1-adrenergic receptor mRNA and density but not signaling in neonatal rat cardiac myocytes.
- An improved permeabilization protocol for the introduction of peptides into cardiac myocytes. Application to protein kinase C research.
- Alpha1-adrenergic receptor subtype mRNAs are differentially regulated by alpha1-adrenergic and other hypertrophic stimuli in cardiac myocytes in culture and in vivo. R...
- A phorbol ester augments cAMP content and adenylyl cyclase activity in neonatal rat cardiac myocytes despite reduced beta adrenoceptor density.
- Preserved beta-adrenoceptor-mediated adenylyl cyclase activity despite receptor and postreceptor dysfunction in Acute myocardial ischemia.
- Receptor crosstalk: effects of prolonged carbachol exposure on beta 1-adrenoceptors and adenylyl cyclase activity in neonatal rat ventricular myocytes.
- Prolonged incubation with neuropeptide Y upregulates beta-adrenoceptors yet does not cause supersensitivity of beta-adrenoceptor signaling.
- Alpha 1-adrenoceptor-mediated inhibition of cellular cAMP accumulation in neonatal rat ventricular myocytes.
- Chronic hypoxia differentially regulates alpha 1-adrenergic receptor subtype mRNAs and inhibits alpha 1-adrenergic receptor-stimulated cardiac hypertrophy and signaling.
- The response of left ventricular function and size to atrial pacing, volume loading and afterload stress in patients with Coronary artery disease.
- The creatine kinase curve area and peak creatine kinase after Acute myocardial infarction: usefulness and limitations.
- Peak systolic blood pressure/end-systolic volume ratio: assessment at rest and during exercise in normal subjects and patients with Coronary heart disease.
- First-third ejection fraction at rest compared with exercise radionuclide angiography in assessing patients with Coronary artery disease.
- Comparison of early systolic and holosystolic ejection phase indexes by contrast ventriculography in patients with Coronary artery disease.
- Human lung adrenoceptors identified by radioligand binding [proceedings].
- Enhanced left ventricular shortening during chronic volume overload in conscious dogs.
- Right and left ventricular dysfunction in patients with chronic obstructive lung Disease. Assessment by first-pass radionuclide angiography.
- Left ventricular ejection fraction and first third ejection fraction early after Acute myocardial infarction: value for predicting mortality and morbidity.
- Assessment of right ventricular function at rest and during exercise in patients with Coronary heart disease: a new approach using equilibrium radionuclide angiography.
- Safety of electrical cardioversion in patients without digitalis toxicity.
- Enhanced noradrenaline response in cardiomyopathic hamsters: possible relation to changes in adrenoceptors studied by radioligand binding.
- A method for the estimation of right ventricular volume by equilibrium radionuclide angiography.
- Left ventricular size and function after subcutaneous administration of terbutaline.
- Evaluation of left ventricular function in chronic pulmonary Disease by exercise gated equilibrium radionuclide angiography.
- The isovolumic index: a new noninvasive approach to the assessment of left ventricular function in man.
- A simple teaching device for examination of the arterial and venous pulse.
- Scintigraphic study of relation between left ventricular peak systolic pressure and end-systolic volume in patients with Coronary artery disease and normal subjects.
- Tocainide therapy for treatment of ventricular Arrhythmias: assessment with ambulatory electrocardiographic monitoring and treadmill exercise.
- Effect of nitrates on left ventricular size and function during exercise: comparison of sublingual nitroglycerin and nitroglycerin paste.
- Assessment of isovolumic and ejection phase indices of left ventricular performance.
- The initial chest x-ray in Acute myocardial infarction. Prediction of early and late mortality and survival.
- Perioperative cardiac cure.
- In vivo identification and distribution of alpha- and beta-adrenoceptors in rat Heart and lung.
- Human lung adrenoreceptors studied by radioligand binding.
- Chronic Heart failure in the guinea pig increases cardiac alpha 1- and beta-adrenoceptors.
- Alpha-adrenoceptor binding in guinea-pig lung using [3H]-prazosin [proceedings].
- Verapamil competitively inhibits alpha 1-adrenergic and muscarinic but not beta-adrenergic receptors in rat myocardium.
- Metabolism of pirprofen in man, monkey, rat, and mouse.
- Human plasma platelet-derived exosomes: effects of aspirin.
Schools
Columbia University College of Physicians And Surgeons
Bronx Muni Hospital
Georgetown University Hospital
Conditions Treated
- Angina and Acute Coronary Syndrome
- Aortic Valve Disease
- Arrhythmias (incl. Atrial Fibrillation)
- Cardiomegaly
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Doctors Specialties
- Cardiology
Accepted Insurances
Education
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Albert Einstein College of Medicine at Jacobi Medical Center -
Columbia University College of Physicians & Surgeons
Hospital
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San Francisco VA Medical Center -
UCSF Medical Center
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