Physician
Family Medicine
Dr. Jill Siegfried, MD
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Jill Siegfried practices Family Medicine. He went to University of Wisconsin Medical School. University of Wisconsin Medical School is a top medical college. University of Wisconsin Medical School is ranked 28 in research and 9 in primary care medicine He received awards:"CMS Meaningful Use Stage 1 Certification". Jill Siegfried, MD is a published physician. He published 96 publications, including: 'The clinical significance of hepatocyte growth factor for non-small cell lung cancer.' Jill Siegfried accepts Medicare.
Publications
- Incidence of head and neck squamous cell carcinoma among subjects at high risk of lung cancer: Results from the Pittsburgh Lung Screening Study.
- Co-targeting c-Met and COX-2 Leads to Enhanced Inhibition of Lung Tumorigenesis in a Murine Model with Heightened Airway HGF.
- Matrix Metalloproteinase-19 Promotes Metastatic Behavior In Vitro and is Associated with Increased Mortality in Non-small Cell Lung Cancer.
- Erlotinib, erlotinib-sulindac vs. placebo: a randomized, double-blind, placebo-controlled window trial in operable head and neck cancer.
- RET Rearrangements in Lung Adenocarcinoma and Radiation.
- Dosing to rash: A phase II trial of the first-line erlotinib for patients with advanced non-small-cell lung cancer an Eastern Cooperative Oncology Group Study (E3503).
- Phase I trial of carboplatin and etoposide in combination with panobinostat in patients with lung cancer.
- Genetic variation in ESR2 and estrogen receptor-beta expression in lung tumors.
- Optimal threshold in CT quantification of emphysema.
- The prognostic and predictive value of KRAS oncogene substitutions in lung adenocarcinoma.
- Elevated gastrin-releasing peptide receptor mRNA expression in buccal mucosa: Association with head and neck squamous cell carcinoma.
- c-Src Activation Mediates Erlotinib Resistance in Head and Neck Cancer by Stimulating c-Met.
- Computerized identification of airway wall in CT examinations using a 3D active surface evolution approach.
- 15q12 Variants, Sputum Gene Promoter Hypermethylation, and Lung Cancer Risk: A GWAS in Smokers.
- Prospective study of breast MRI in BRCA1 and BRCA2 mutation carriers: effect of mutation status on cancer incidence.
- Hepatocyte growth factor promotes tumor growth in a novel in vivo model of human lung cancer.
- Combined inhibition of c-Src and epidermal growth factor receptor abrogates growth and invasion of head and neck squamous cell carcinoma.
- Nicotine signals through muscle-type and neuronal nicotinic acetylcholine receptors in both human bronchial epithelial cells and airway fibroblasts.
- Detection of infrequent and multiple K-ras mutations in human tumors and tumor-adjacent tissues.
- Topographic analysis of K- ras mutations in histologically normal lung tissues and tumours of lung cancer patients.
- Comparative genomic hybridization analysis detects frequent, often high-level, overrepresentation of DNA sequences at 3q, 5p, 7p, and 8q in human non-small cell lung c...
- Non-small-cell lung cancer and breast carcinoma: chemotherapy and beyond.
- Phosphorylation of TNF-alpha converting enzyme by gastrin-releasing peptide induces amphiregulin release and EGF receptor activation.
- Detection of low-fraction K-ras mutations in primary lung tumors using a sensitive method.
- Biology and chemoprevention of lung cancer.
- Lung cancer screening in high-risk populations.
- Comparison of p53 mutations between adenocarcinoma and squamous cell carcinoma of the lung: unique spectra involving G to A transitions and G to T transversions in bot...
- Women and lung cancer: does oestrogen play a role?
- Prognostic value of specific KRAS mutations in lung adenocarcinomas.
- Detection of micrometastases in histologically negative lymph nodes in esophageal cancer.
- Kinin b2 receptor mediates induction of cyclooxygenase-2 and is overexpressed in head and neck squamous cell carcinomas.
- Multiple cytokine and growth factor serum biomarkers predict therapeutic response and survival in advanced-stage head and neck cancer patients.
- Promoter methylation of RASSF1A and DAPK and mutations of K-ras, p53, and EGFR in lung tumors from smokers and never-smokers.
- Trinucleotide repeat length variation in the human ribosomal protein L14 gene (RPL14): localization to 3p21.3 and loss of heterozygosity in lung and oral cancers.
- Expression of mRNA for gastrin-releasing peptide receptor by human bronchial epithelial cells. Association with prolonged tobacco exposure and responsiveness to bombes...
- Cross-talk between G protein-coupled receptor and epidermal growth factor receptor signaling pathways contributes to growth and invasion of head and neck squamous cell...
- Association of polymorphisms in the cyclin D1 and XPD genes and susceptibility to cancers of the upper aero-digestive tract.
- Immunohistochemical analysis of phosphotyrosine signal transducer and activator of transcription 3 and epidermal growth factor receptor autocrine signaling pathways in...
- Detection of occult lymph node metastases in esophageal cancer by minimally invasive staging combined with molecular diagnostic techniques.
- Association of the DNA repair gene XPD Asp312Asn polymorphism with p53 gene mutations in tobacco-related non-small cell lung cancer.
- Clinical relevance of chromosome abnormalities in non-small cell lung cancer.
- Lung cancer-derived bombesin-like peptides down-regulate the generation and function of human dendritic cells.
- Downregulation of Dkk3 activates beta-catenin/TCF-4 signaling in lung cancer.
- Mitogenic effects of gastrin-releasing peptide in head and neck squamous cancer cells are mediated by activation of the epidermal growth factor receptor.
- No association between the XPD 312, 751, or XRCC1 399 polymorphisms and K-ras gene mutation in smoking non-small-cell lung cancer.
- Fibulin-5 suppresses lung cancer invasion by inhibiting matrix metalloproteinase-7 expression.
- Gastrin-releasing peptide activates Akt through the epidermal growth factor receptor pathway and abrogates the effect of gefitinib.
- Impact of tumor size on outcomes after anatomic lung resection for stage 1A non-small cell lung cancer based on the current staging system.
- Multiplexed analysis of serum cytokines as biomarkers in squamous cell carcinoma of the head and neck patients.
- Sex and gender differences in lung cancer.
- Association of radiographic emphysema and airflow obstruction with lung cancer.
- Therapeutic targeting of human hepatocyte growth factor with a single neutralizing monoclonal antibody reduces lung tumorigenesis.
- Doubling times and CT screen–detected lung cancers in the Pittsburgh Lung Screening Study.
- Association of the EGFR intron 1 CA repeat length with lung cancer risk.
- HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer.
- Elevated hepatocyte growth factor level correlates with poor outcome in early-stage and late-stage adenocarcinoma of the lung.
- SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells.
- Molecular analysis of plasma DNA for the early detection of lung cancer by quantitative methylation-specific PCR.
- Fluorescence bronchoscopic surveillance after curative surgical resection for non-small-cell lung cancer.
- Influence of Age and IB Status After Resection of Node-Negative Non-Small Cell Lung Cancer.
- Association of immunoreactive hepatocyte growth factor with poor survival in resectable non-small cell lung cancer.
- Mutation and polymorphism in the EGFR-TK domain associated with lung cancer.
- Increased levels of tumor-infiltrating lymphocytes are associated with improved recurrence-free survival in stage 1A non-small-cell lung cancer.
- Nicotine activates cell-signaling pathways through muscle-type and neuronal nicotinic acetylcholine receptors in non-small cell lung cancer cells.
- Frequent inactivation of RAMP2, EFEMP1 and Dutt1 in lung cancer by promoter hypermethylation.
- Pilot study of gefitinib and fulvestrant in the treatment of post-menopausal women with advanced non-small cell lung cancer.
- Gastrin-releasing peptide receptor mediates activation of the epidermal growth factor receptor in lung cancer cells.
- Antitumor mechanisms of combined gastrin-releasing peptide receptor and epidermal growth factor receptor targeting in head and neck cancer.
- The Pittsburgh Lung Screening Study (PLuSS): outcomes within 3 years of a first computed tomography scan.
- Cross-talk between estrogen receptor and epidermal growth factor receptor in head and neck squamous cell carcinoma.
- Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells.
- Diagnostic accuracy of MALDI mass spectrometric analysis of unfractionated serum in lung cancer.
- HGF-independent potentiation of EGFR action by c-Met.
- Unlocking biomarker discovery: large scale application of aptamer proteomic technology for early detection of lung cancer.
- Combining the Multitargeted Tyrosine Kinase Inhibitor Vandetanib with the Antiestrogen Fulvestrant Enhances Its Antitumor Effect in Non-small Cell Lung Cancer.
- Multianalyte profiling of serum cytokines for detection of pancreatic cancer.
- Lung cancer serum biomarker discovery using label-free liquid chromatography-tandem mass spectrometry.
- Inhibition of human non-small cell lung tumors by a c-Met antisense/U6 expression plasmid strategy.
- Estrogen receptor pathways in lung cancer.
- Gastrin-releasing peptide receptor-mediated autocrine growth in squamous cell carcinoma of the head and neck.
- Transgenic mice overexpressing hepatocyte growth factor in the airways show increased susceptibility to lung cancer.
- Early detection of head and neck cancer: development of a novel screening tool using multiplexed immunobead-based biomarker profiling.
- Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer.
- Signaling pathways involved in cyclooxygenase-2 induction by hepatocyte growth factor in non small-cell lung cancer.
- Estrogen receptor signaling in lung cancer.
- Evidence for autocrine actions of neuromedin B and gastrin-releasing peptide in non-small cell lung cancer.
- The clinical significance of hepatocyte growth factor for non-small cell lung cancer.
- Combined analysis of estrogen receptor beta-1 and progesterone receptor expression identifies lung cancer patients with poor outcome.
- Human non-small cell lung tumors and cells derived from normal lung express both estrogen receptor alpha and beta and show biological responses to estrogen.
- Regulation of endogenous gene expression in human non-small cell lung cancer cells by estrogen receptor ligands.
- Combined targeting of the estrogen receptor and the epidermal growth factor receptor in non-small cell lung cancer shows enhanced antiproliferative effects.
- Serum biomarker profiles as diagnostic tools in lung cancer.
- Lung cancer serum biomarker discovery using glycoprotein capture and liquid chromatography mass spectrometry.
- Early changes in pulmonary gene expression following tobacco exposure shed light on the role of estrogen metabolism in lung carcinogenesis.
- Estrogen receptor beta (ERbeta) subtype-specific ligands increase transcription, p44/p42 mitogen activated protein kinase (MAPK) activation and growth in human non-sma...
Schools
University of Pittsburgh School of Medicine
Doctors Specialties
- Family Medicine
Accepted Insurances
- Aetna HMO
- Choice Plus POS II
- Pathway X Bronze Direct CACA IN HIX
- Anthem Blue Cross Blue Shield PPO
- Blue Card PPO
- Cigna HMO
- Cigna PPO
- Great West Healthcare-Cigna PPO
- Open Access Plus
- Cofinity PPO
- MultiPlan PPO
- PHCS Network PPO
- Choice Plus POS
- Navigate HMO
- Navigate POS
- Options PPO
Awards
- CMS Meaningful Use Stage 1 Certification
Education
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University of Wisconsin Medical School -
University of Pittsburgh School of Medicine
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