Adjunct Professor, Anesthesiology, University of Maryland School of Medicine

Pulmonology

James H. Shelhamer works in the field of Pulmonology. He over the years received 1 awards: "Elected Member". James H. Shelhamer, MD is a published doctor. He has 35 publications published. The most current publication "Validation of Normal Human Bronchial Epithelial Cells as a Model for Influenza A Infections in Human Distal Trachea."

Publications

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• Validation of Normal Human Bronchial Epithelial Cells as a Model for Influenza A Infections in Human Distal Trachea.
• SARS-Coronavirus Open Reading Frame-9b Suppresses Innate Immunity by Targeting Mitochondria and the MAVS/TRAF3/TRAF6 Signalosome.
• Low molecular weight hyaluronan activates cytosolic phospholipase a2α and eicosanoid production in monocytes and macrophages.
• Changes in MicroRNA and mRNA expression with Differentiation of Human Bronchial Epithelial Cells.
• Abnormal Nasal Nitric Oxide Production, Ciliary Beat Frequency and TLR Response in Pulmonary NTM Disease Epithelium.
• National Institutes of Health Chronic Graft-versus-Host Disease Staging in Severely Affected Patients: Organ and Global Scoring Correlate with Established Indicators o...
• A cytosolic phospholipase A2-initiated lipid mediator pathway induces autophagy in macrophages.
• Lung Size Mismatch in Bilateral Lung Transplantation Is Associated With Allograft Function and Bronchiolitis Obliterans Syndrome.
• Prostaglandin E2 potentiates heat shock-induced heat shock protein 72 expression in A549 cells.
• Concentration-dependent noncysteinyl leukotriene type 1 receptor-mediated inhibitory activity of leukotriene receptor antagonists.
• Cytosolic phospholipase A2alpha activation induced by S1P is mediated by the S1P3 receptor in lung epithelial cells.
• IL-10 inhibits cysteinyl leukotriene-induced activation of human monocytes and monocyte-derived dendritic cells.
• Leukotriene D(4) induces gene expression in human monocytes through cysteinyl leukotriene type I receptor.
• IFN-gamma induces cysteinyl leukotriene receptor 2 expression and enhances the responsiveness of human endothelial cells to cysteinyl leukotrienes.
• Polyamine-mediated reduction in human airway epithelial migration in response to wounding is PGE2 dependent through decreases in COX-2 and cPLA2 protein levels.
• TLR4-NOX4-AP-1 signaling mediates lipopolysaccharide-induced CXCR6 expression in human aortic smooth muscle cells.
• Gene expression profiles of peripheral blood leukocytes after endotoxin challenge in humans.
• Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages.
• Functional characterization of human cysteinyl leukotriene 1 receptor gene structure.
• Influence of IFN-gamma on gene expression in normal human bronchial epithelial cells: modulation of IFN-gamma effects by dexamethasone.
• Cytosolic phospholipase A2 Group IValpha but not secreted phospholipase A2 Group IIA, V, or X induces interleukin-8 and cyclooxygenase-2 gene and protein expression th...
• Transforming growth factor-beta (TGF-beta) activates cytosolic phospholipase A2alpha (cPLA2alpha)-mediated prostaglandin E2 (PGE)2/EP1 and peroxisome proliferator-acti...
• Blood mononuclear cell gene expression profiles characterize the oxidant, hemolytic, and inflammatory stress of sickle cell disease.
• Involvement of p38 and p42/44 MAP kinases and protein kinase C in the interferon-gamma and interleukin-1alpha-induced phosphorylation of 85-kDa cytosolic phospholipase...
• PPARgamma ligands inhibit cholangiocarcinoma cell growth through p53-dependent GADD45 and p21 pathway.
• Inflammation-promoting activity of HMGB1 on human microvascular endothelial cells.
• Interferon-gamma induces p11 gene and protein expression in human epithelial cells through interferon-gamma-activated sequences in the p11 promoter.
• Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway.
• Oxidant-induced cell death in respiratory epithelial cells is due to DNA damage and loss of ATP.
• Epidermal growth factor induces p11 gene and protein expression and down-regulates calcium ionophore-induced arachidonic acid release in human epithelial cells.
• 85-kDa cytosolic phospholipase A2 mediates peroxisome proliferator-activated receptor gamma activation in human lung epithelial cells.
• Involvement of 85-kd cytosolic phospholipase A(2) and cyclooxygenase-2 in the proliferation of human cholangiocarcinoma cells.
• 85-kDa cPLA(2) plays a critical role in PPAR-mediated gene transcription in human hepatoma cells.
• CT virtual bronchoscopy of the central airways in patients with Wegener's granulomatosis.

Schools

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• Baylor University

Doctors Specialties

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• Critical Care Medicine
• Pulmonology

Accepted Insurances

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Awards

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• Elected Member

Hospital

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• University of Maryland Medical Center

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