Physician
Internal Medicine
Dr. Ira D. Goldfine, MD
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Goldfine practices Internal Medicine. He studied medicine at University of Illinois College of Medicine. He has 1 awards "Elected Member". Ira D. Goldfine, MD is a published doctor and has 102 publications published. The lastest was: 'Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals.'
Publications
- Differential Pathway Coupling of the Activated Insulin Receptor Drives Signaling Selectivity by XMetA, an Allosteric Partial Agonist Antibody.
- Acute Treatment with XMetA Activates Hepatic Insulin Receptors and Lowers Blood Glucose in Normal Mice.
- Selective Allosteric Antibodies to the Insulin Receptor for the Treatment of Hyperglycemic and Hypoglycemic Disorders.
- Inhibition of insulin receptor function by a human, allosteric monoclonal antibody: A potential new approach for the treatment of hyperinsulinemic hypoglycemia.
- Detailed Mechanistic Analysis of Gevokizumab, an Allosteric Anti-IL-1β Antibody with Differential Receptor-Modulating Properties.
- Evidence that an HMGA1 Gene Variant Associates with Type 2 Diabetes, Body Mass Index, and High-Density Lipoprotein Cholesterol in a Hispanic-American Population.
- XMetA, an allosteric monoclonal antibody to the insulin receptor, improves glycaemic control in mice with diet-induced obesity.
- XOMA 052, an anti-IL-1? monoclonal antibody, prevents IL-1? mediated insulin resistance in 3T3-L1 adipocytes.
- Functional variants of the HMGA1 gene and type 2 diabetes mellitus.
- Insulin Resistance in Non-Obese Subjects Is Associated with Activation of the JNK Pathway and Impaired Insulin Signaling in Skeletal Muscle.
- Effects of controlled-release alpha lipoic acid in lean, nondiabetic patients with polycystic ovary syndrome.
- Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects.
- Influence of gender on the relationship between insulin sensitivity, adiposity, and plasma lipids in lean nondiabetic subjects.
- Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.
- Design, synthesis, and structure-activity relationships of novel insulin receptor tyrosine kinase activators.
- Inhibitory effects of nordihydroguaiaretic acid (NDGA) on the IGF-1 receptor and androgen dependent growth of LAPC-4 prostate cancer cells.
- Technical evaluation of in vivo abdominal fat and IMCL quantification using MRI and MRSI at 3 T.
- Nordihydroguaiaretic acid (NDGA), an inhibitor of the HER2 and IGF-1 receptor tyrosine kinases, blocks the growth of HER2-overexpressing human breast cancer cells.
- The role of membrane glycoprotein plasma cell antigen 1/ectonucleotide pyrophosphatase phosphodiesterase 1 in the pathogenesis of insulin resistance and related abnorm...
- Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
- Expression of insulin-like growth factor-1 receptor in local and metastatic prostate cancer.
- Parallel synthesis of diarylureas and their evaluation as inhibitors of insulin-like growth factor receptor.
- IGF-binding protein-1 levels are related to insulin-mediated glucose disposal and are a potential serum marker of insulin resistance.
- Overexpression of the insulin receptor inhibitor PC-1/ENPP1 induces insulin resistance and hyperglycemia.
- Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth.
- Variants of ENPP1 are associated with childhood and adult obesity and increase the risk of glucose intolerance and type 2 diabetes.
- The molecular basis for oxidative stress-induced insulin resistance.
- Analysis of insulin-stimulated insulin receptor activation and glucose transport in cultured skeletal muscle cells from obese subjects.
- Increased hepatic levels of the insulin receptor inhibitor, PC-1/NPP1, induce insulin resistance and glucose intolerance.
- Effective treatments for insulin resistance: trim the fat and douse the fire.
- In vitro and in vivo prevention of HIV protease inhibitor-induced insulin resistance by a novel small molecule insulin receptor activator.
- Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?
- Inadvertent sulfonylurea overdosage and hypoglycemia in an elderly woman: failure of serum hypoglycemia screening.
- Regulation of insulin receptor function by a small molecule insulin receptor activator.
- Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes.
- Decreased insulin receptor (IR) autophosphorylation in fibroblasts from patients with PCOS: effects of serine kinase inhibitors and IR activators.
- Elevated plasma cell membrane glycoprotein levels and diminished insulin receptor autophosphorylation in obese, insulin-resistant rhesus monkeys.
- Pharmacokinetics, tolerability, and fructosamine-lowering effect of a novel, controlled-release formulation of alpha-lipoic acid.
- Insulin resistance induced by hyperinsulinemia coincides with a persistent alteration at the insulin receptor tyrosine kinase domain.
- Improved glucose metabolism in vitro and in vivo by an allosteric monoclonal antibody that increases insulin receptor binding affinity.
- Hyperleydigism: a cause of severe pubertal gynecomastia.
- PC-1 nucleoside triphosphate pyrophosphohydrolase deficiency in idiopathic infantile arterial calcification.
- An analysis of insulin receptor expression and binding on MHC class I positive and negative human lymphoblastoid cells.
- Differential phosphorylation of the progesterone receptor by insulin, epidermal growth factor, and platelet-derived growth factor receptor tyrosine protein kinases.
- Insulin resistance and insulin secretion are determinants of oral glucose tolerance in normal individuals.
- Insulin-like growth factor-I receptors are overexpressed and predict a low risk in human breast cancer.
- Characterization of human placental insulin-like growth factor-I/insulin hybrid receptors by protein microsequencing and purification.
- Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor, p62, and GTPase-activating protein.
- Insulin-resistant MDA-MB231 human breast cancer cells contain a tyrosine kinase inhibiting activity.
- Deletion of residues 485-599 from the human insulin receptor abolishes antireceptor antibody binding and influences tyrosine kinase activation.
- Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002.
- Inhibitors of insulin receptor tyrosine kinase in fibroblasts from diverse patients with impaired insulin action: evidence for a novel mechanism of postreceptor insuli...
- Inhibition of insulin receptor phosphorylation by PC-1 is not mediated by the hydrolysis of adenosine triphosphate or the generation of adenosine.
- Role of p85 subunit of phosphatidylinositol-3-kinase as an adaptor molecule linking the insulin receptor to insulin receptor substrate 1.
- Insulin receptor overexpression in 184B5 human mammary epithelial cells induces a ligand-dependent transformed phenotype.
- Insulin receptor gene expression and insulin resistance.
- Rodent insulin receptors are immunologically different from other mammalian insulin receptors.
- Binding of thyroid hormones and analogues to the human plasma protein prealbumin.
- Effect of amiodarone on L-triiodothyronine stimulation of [3H] thymidine incorporation into GH3 cells.
- Chloroquine stimulation of insulin binding to IM-9 lymphocytes: evidence for action at a nonlysosomal site.
- Comparison of the in vitro effect of biguanides and sulfonylureas on insulin binding of its receptors in target cells.
- Production of antibodies that inhibit the binding of insulin to its receptor.
- Phenformin stimulation of insulin binding to human cultured lymphocytes.
- Interaction of insulin, polypeptide hormones, and growth factors with intracellular membranes.
- Insulin-ricin B chain conjugate. A hybrid molecule with ricin-binding activity and insulin biological activity.
- Electron microscope autoradiographic analysis of [125I]iodoinsulin entry into adult rat hepatocytes in vivo: evidence for multiple sites of hormone localization.
- Insulin action in pancreatic acini from streptozotocin-treated rats. III. Electron microscope autoradiography of 125I-insulin.
- Insulin action in pancreatic acini from streptozotocin-treated rats. II. Binding of 125I-insulin to receptors.
- Rapid regulation of plasma membrane insulin receptors.
- Bile secretory apparatus: evidence for a vesicular transport mechanism for proteins in the rat, using horseradish peroxidase and [125I]insulin.
- Insulin regulation of sugar transport in isolated pancreatic acini from diabetic mice.
- Action of insulin at the nuclear envelope.
- Effects of biguanides and sulfonylureas on insulin receptors in cultured cells.
- Regulation of pancreatic acinar cell insulin receptors by insulin.
- Methylamine and monensin do not block insulin internalization but do influence the intracellular distribution and action of insulin in pancreatic acini from diabetic m...
- ATP and other nucleoside triphosphates inhibit the binding of insulin to its receptor.
- In vivo localization of insulin binding to cells of the rat pancreas.
- Characterization of the serum from a patient with insulin resistance and hypoglycemia. Evidence for multiple populations of insulin receptor antibodies with different ...
- Degradation of insulin by isolated mouse pancreatic acini. Evidence for cell surface protease activity.
- The effect of chloroquine on the binding, intracellular distribution, and action of insulin on isolated mouse pancreatic acini.
- Regulation of the insulin receptor by a monoclonal anti-receptor antibody. Evidence that receptor down regulation can be independent of insulin action.
- Regulation of insulin receptor kinase activity by insulin mimickers and an insulin antagonist.
- Insulin receptor antiserum and plant lectins mimic the direct effects of insulin on nuclear envelope phosphorylation.
- Insulin-ricin B chain conjugate has enhanced biological activity in insulin-insensitive cells.
- The effect of phenformin and other adenosine triphosphate (ATP)-lowering agents on insulin binding to IM-9 human cultured lymphocytes.
- Cholecystokinin and insulin regulate insulin-like growth factor II binding to pancreatic receptors; evidence of a role for intracellular calcium.
- Pancreatic CCK receptors: characterization of covalently labeled subunits.
- Insulinlike growth factors bind to specific receptors in isolated pancreatic acini.
- Characterization of cholecystokinin receptor subunits on pancreatic plasma membranes.
- Interactions of a monoclonal antibody to the insulin receptor with receptors for insulin-like growth factors.
- Insulin regulation of protein phosphorylation in isolated rat liver nuclear envelopes: potential relationship to mRNA metabolism.
- The CCK receptor on pancreatic plasma membranes: binding characteristics and covalent cross-linking.
- Quantitative electron microscope autoradiographs of 125I-cholecystokinin in pancreatic acini.
- Alterations of brain cholecystokinin receptors in mice made obese with goldthioglucose.
- Insulin stimulation of nucleoside triphosphatase activity in isolated nuclear envelopes.
- Characterization of receptors for cholecystokinin and related peptides in mouse cerebral cortex.
- Receptors for cholecystokinin and insulin in isolated pancreatic acini: hormonal control of secretion and metabolism.
- Alterations of brain cerebral cortex CCK receptors in the ob/ob mouse.
- Regenerating rat liver: insulin and glucagon serum levels and receptor binding.
- Alterations in brain cholecystokinin receptors after fasting.
- A New Road for Treating the Vascular Complications of Diabetes: So Let's Step on the Gas.
Schools
University Of Illinois College Of Medicine Chicago
Conditions Treated
- Hyperlipidemia
- Hyperparathyroidism
Doctors Specialties
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
-
University of Chicago -
University of Illinois College of Medicine
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