Infectious Diseases
Infectious Disease
Dr. Howard E. Gendelman, MD
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Howard Gendelman is an expert in the field of Infectious Disease. He studied medicine at Penn State College of Medicine. Howard Gendelman is a published doctor and has 100 publications published. The lastest was: 'Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease.'
Publications
- Immunomodulation as a neuroprotective and therapeutic strategy for Parkinson's disease.
- A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders.
- The mixed lineage kinase-3 inhibitor URMC-099 improves therapeutic outcomes for long-acting antiretroviral therapy.
- Pharmacodynamics of long-acting folic acid-receptor targeted ritonavir-boosted atazanavir nanoformulations.
- Nanoneuromedicines for degenerative, inflammatory, and infectious nervous system diseases.
- Enabling nanomaterial, nanofabrication and cellular technologies for nanoneuromedicines.
- Brain Region Mapping Using Global Metabolomics.
- Granulocyte-Macrophage Colony Stimulating Factor Exerts Protective and Immunomodulatory Effects in Cortical Trauma.
- Pharmacokinetics, Biodistribution, and Toxicity of Folic Acid-Coated Antiretroviral Nanoformulations.
- Adjunctive and long-acting nanoformulated antiretroviral therapies for HIV-associated neurocognitive disorders.
- Nanomedicine for the Viral Reservoir Drug Delivery and the Fight Against HIV Infection.
- Hyper-synchrony despite pathologically-reduced beta oscillations in patients with Parkinson's disease: A pharmaco-magnetoencephalography study.
- Endosomal Trafficking of Nanoformulated Antiretroviral Therapy Facilitates Drug Particle Carriage and HIV Clearance.
- Cellular Interactions and Signaling in neuroAIDS: Emerging Issues Colloquium.
- Fourth annual conference of the american society for nanomedicine.
- Formulation design facilitates magnetic nanoparticle delivery to diseased cells and tissues.
- Bench-to-bedside translation of magnetic nanoparticles.
- Interview: Nanomedicine and the fight against HIV/AIDS.
- The promise of nanoneuromedicine.
- GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice.
- Lipids and cognition make good bedfellows for neuroAIDS.
- Bridge Between Neuroimmunity and Traumatic Brain Injury.
- Improved visualization of neuronal injury following glial activation by manganese enhanced MRI.
- Small magnetite antiretroviral therapeutic nanoparticle probes for MRI of drug biodistribution.
- Combinatorial assessments of brain tissue metabolomics and histopathology in rodent models of human immunodeficiency virus infection.
- Neuromagnetic Evidence of Abnormal Movement-Related Beta Desynchronization in Parkinson's Disease.
- Macrophage Folate Receptor-Targeted Antiretroviral Therapy Facilitates Drug Entry, Retention, Antiretroviral Activities and Biodistribution for Reduction of Human Immu...
- Enhancement of NMDA Receptor-Mediated Excitatory Postsynaptic Currents by gp120-Treated Macrophages: Implications for HIV-1-Associated Neuropathology.
- Preclinical Pharmacokinetics and Tissue Distribution of Long-Acting Nanoformulated Antiretroviral Therapy.
- Functional Proteome of Macrophage Carried Nanoformulated Antiretroviral Therapy Demonstrates Enhanced Particle Carrying Capacity.
- CCL2 affects ?-amyloidosis and progressive neurocognitive dysfunction in a mouse model of Alzheimer's disease.
- Long-acting parenteral nanoformulated antiretroviral therapy: interest and attitudes of HIV-infected patients.
- Mouse brain fixation to preserve In vivo manganese enhancement for ex vivo manganese-enhanced MRI.
- Change in evolution.
- Pharmacodynamic and antiretroviral activities of combination nanoformulated antiretrovirals in HIV-1-infected human peripheral blood lymphocyte-reconstituted mice.
- CD4+ Regulatory and Effector/Memory T Cell Subsets Profile Motor Dysfunction in Parkinson's Disease.
- Long-acting NanoART ElicitsPotent antiretroviral and neuroprotective responses in HIV-1 Infected Humanized Mice.
- A model of nitric oxide induced α-synuclein misfolding in Parkinson's disease.
- Biochemical and Biologic Characterization of Exosomes and Microvesicles as Facilitators of HIV-1 Infection in Macrophages.
- Mononuclear phagocyte intercellular crosstalk facilitates transmission of cell-targeted nanoformulated antiretroviral drugs to human brain endothelial cells.
- Commentary: Animal models of neuroAIDS.
- Rapid and reliable quantitation of amino acids and myo-inositol in mouse brain by high performance liquid chromatography and tandem mass spectrometry.
- Blood-borne macrophage-neural cell interactions hitchhike endosome networks for cell-based nanozyme brain delivery.
- Can Humanized Mice Reflect the Complex Pathobiology of HIV-Associated Neurocognitive Disorders?
- Landmark optimization using local curvature for point-based nonlinear rodent brain image registration.
- Neuroprotective activities of regulatory T cells.
- Changes in the plasma proteome follows chronic opiate administration in simian immunodeficiency virus infected rhesus macaques.
- Human Immunodeficiency Virus type 1 Endocytic Trafficking Through Macrophage Bridging Conduits Facilitates Spread of Infection.
- Proteomic biosignatures for monocyte-macrophage differentiation.
- Methamphetamine-Associated Psychosis.
- UPLC-MS/MS quantification of nanoformulated ritonavir, indinavir, atazanavir, and efavirenz in mouse serum and tissues.
- Macrophage Bridging Conduit Trafficking of HIV-1 Through the Endoplasmic Reticulum and Golgi Network.
- Pulsed Stable Isotope Labeling of Amino Acids in Cell Culture Uncovers the Dynamic Interactions between HIV-1 and the Monocyte-Derived Macrophage.
- Cell-mediated transfer of catalase nanoparticles from macrophages to brain endothelial, glial and neuronal cells.
- Murine Motor and Behavior Functional Evaluations for Acute 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) Intoxication.
- Macrophage endocytic trafficking of antiretroviral nanoparticles.
- Loss of neuronal integrity during progressive HIV-1 infection of humanized mice.
- Pharmacotoxicology of monocyte-macrophage nanoformulated antiretroviral drug uptake and carriage.
- Functional proteomic analysis for regulatory T cell surveillance of the HIV-1-infected macrophage.
- Nanoformulated antiretroviral drug combinations extend drug release and antiretroviral responses in HIV-1-infected macrophages: implications for neuroAIDS therapeutics.
- Links between progressive HIV-1 infection of humanized mice and viral neuropathogenesis.
- Rebuilding synaptic architecture in HIV-1 associated neurocognitive disease: a therapeutic strategy based on modulation of mixed lineage kinase.
- Plasma proteomic analysis of simian immunodeficiency virus infection of rhesus macaques.
- Immunoregulation of a CB2 receptor agonist in a murine model of neuroAIDS.
- CNS expression of anti-inflammatory cytokine interleukin-4 attenuates Alzheimer's disease-like pathogenesis in APP+PS1 bigenic mice.
- CD8+ cell depletion accelerates HIV-1 immunopathology in humanized mice.
- Molecular mechanisms involving sigma receptor-mediated induction of MCP-1: implication for increased monocyte transmigration.
- Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease.
- Control of neuroinflammation as a therapeutic strategy for amyotrophic lateral sclerosis and other neurodegenerative disorders.
- HIV-1 neuroimmunity in the era of antiretroviral therapy.
- Neuroprotective activities of CEP-1347 in models of neuroAIDS.
- Methods development for blood borne macrophage carriage of nanoformulated antiretroviral drugs.
- Simvastatin inhibits the activation of p21ras and prevents the loss of dopaminergic neurons in a mouse model of Parkinson's disease.
- A coat of many colors: neuroimmune crosstalk in human immunodeficiency virus infection.
- 4-Aminopyridine improves spatial memory in a murine model of HIV-1 encephalitis.
- Innate and adaptive immunity for the pathobiology of Parkinson's disease.
- Proteomic studies of nitrated alpha-synuclein microglia regulation by CD4+CD25+ T cells.
- Macrophage delivery of nanoformulated antiretroviral drug to the brain in a murine model of neuroAIDS.
- AAV1/2-mediated CNS gene delivery of dominant-negative CCL2 mutant suppresses gliosis, beta-amyloidosis, and learning impairment of APP/PS1 mice.
- Nitrated {alpha}-synuclein-induced alterations in microglial immunity are regulated by CD4+ T cell subsets.
- Lithium therapy for human immunodeficiency virus type 1-associated neurocognitive impairment.
- Neuromodulatory activities of CD4+CD25+ regulatory T cells in a murine model of HIV-1-associated neurodegeneration.
- Monocyte chemotactic protein-1 regulates voltage-gated K+ channels and macrophage transmigration.
- Facilitated monocyte-macrophage uptake and tissue distribution of superparmagnetic iron-oxide nanoparticles.
- CCL2 accelerates microglia-mediated Abeta oligomer formation and progression of neurocognitive dysfunction.
- HIV-1 transforms the monocyte plasma membrane proteome.
- HIV-1-infected astrocytes and the microglial proteome.
- The promise and perils of CNS drug delivery: a video debate.
- Disseminating research discovery through an interactive video: a paradigm shift for journal publication.
- Nitrated alpha-synuclein and microglial neuroregulatory activities.
- STAT1 signaling modulates HIV-1-induced inflammatory responses and leukocyte transmigration across the blood-brain barrier.
- Modulation of innate immunity by copolymer-1 leads to neuroprotection in murine HIV-1 encephalitis.
- Adaptive immune neuroprotection in G93A-SOD1 amyotrophic lateral sclerosis mice.
- Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons.
- Proteomic modeling for HIV-1 infected microglia-astrocyte crosstalk.
- Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease.
- Cerebrospinal fluid proteomic profiling of HIV-1-infected patients with cognitive impairment.
- Neuroprotective activities of CD4+CD25+ regulatory T cells in an animal model of Parkinson's disease.
Schools
Pennsylvania State University College of Medicine
Montefiore Med Center
Johns Hopkins University
Doctors Specialties
- Internal Medicine
- Infectious Disease
Accepted Insurances
Education
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Johns Hopkins University -
Albert Einstein - Montefiore Medical Center -
Penn State College of Medicine
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