Professor, Medicine, UCSF School of Medicine
Pulmonology
Dr. George H. Caughey, MD
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George Caughey works in the field of Pulmonology. He attended Stanford University School of Medicine. Stanford University School of Medicine is a top medical university. Stanford University School of Medicine is ranked 2 in research and 25 in primary care medicine He over the years received 1 awards: "Elected Member". George Caughey has written publications. He has 101 publications published with PubMed. The lastest paper is: 'Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms.'
Publications
- Dipeptidyl Peptidase I Controls Survival from Klebsiella pneumoniae Lung Infection by Processing Surfactant Protein D.
- Bronchoalveolar Lavage Cell Immunophenotyping Facilitates Diagnosis of Lung Allograft Rejection.
- Malaria-associated L-Arginine deficiency induces mast cell-associated disruption to intestinal barrier defenses against non-typhoidal Salmonella bacteremia.
- Cathepsin L Protects Mice from Mycoplasmal Infection and is Essential for Airway Lymphangiogenesis.
- Mutational Tail Loss is an Evolutionary Mechanism for Liberating marapsins and other type I serine proteases from transmembrane anchors.
- Association of large-airway lymphocytic bronchitis with bronchiolitis obliterans syndrome.
- The ?v?6 integrin modulates airway hyperresponsiveness in mice by regulating intraepithelial mast cells.
- Strain-dependent induction of neutrophil histamine production and cell death by Pseudomonas aeruginosa.
- Parasitic infection improves survival from septic peritonitis by enhancing mast cell responses to bacteria in mice.
- Mast cell proteases as protective and inflammatory mediators.
- How immune peptidases change specificity: cathepsin G gained tryptic function but lost efficiency during primate evolution.
- Accumulation of intraepithelial mast cells with a unique protease phenotype in T(H)2-high Asthma.
- Mast cell peptidases: chameleons of innate immunity and host defense.
- Human subjects are protected from mast cell tryptase deficiency despite frequent inheritance of loss-of-function mutations.
- Ex vivo sputum analysis reveals impairment of protease-dependent mucus degradation by plasma proteins in acute Asthma.
- Alpha 2-macroglobulin capture allows detection of mast cell chymase in serum and creates a reservoir of angiotensin II-generating activity.
- Guinea pig chymase is leucine-specific: a novel example of functional plasticity in the chymase/granzyme family of serine peptidases.
- Chimerism, point mutation, and truncation dramatically transformed mast cell delta-tryptases during primate evolution.
- Mast cell alpha and beta tryptases changed rapidly during primate speciation and evolved from gamma-like transmembrane peptidases in ancestral vertebrates.
- Tryptase haplotype in mastocytosis: relationship to Disease variant and diagnostic utility of total tryptase levels.
- Protease-activated receptor 2, dipeptidyl peptidase I, and proteases mediate Clostridium difficile toxin A enteritis.
- Regulation of the epithelial Na+ channel by peptidases.
- Neutrophil histamine contributes to inflammation in mycoplasma pneumonia.
- Prostasin regulates epithelial monolayer function: cell-specific Gpld1-mediated secretion and functional role for GPI anchor.
- A Pulmonary Perspective on GASPIDs: Granule-Associated Serine Peptidases of Immune Defense.
- Tryptase genetics and anaphylaxis.
- Mast cell and neutrophil peptidases attack an inactivation segment in hepatocyte growth factor to generate NK4-like antagonists.
- Mast cells protect mice from Mycoplasma pneumonia.
- Transcript signatures of lymphocytic bronchitis in Lung allograft biopsy specimens.
- Mastin is a gelatinolytic mast cell peptidase resembling a mini-proteasome.
- Prostasin, a membrane-anchored serine peptidase, regulates sodium currents in JME/CF15 cells, a cystic fibrosis airway epithelial cell line.
- Matrix metalloproteinase-2 and -9 expression increases in Mycoplasma-infected airways but is not required for microvascular remodeling.
- Mouse prostasin gene structure, promoter analysis, and restricted expression in Lung and kidney.
- Mast cell dipeptidyl peptidase I mediates survival from sepsis.
- Albumin is a substrate of human chymase. Prediction by combinatorial peptide screening and development of a selective inhibitor based on the albumin cleavage site.
- Structure of human pro-chymase: a model for the activating transition of granule-associated proteases.
- Building a better heparin.
- Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.
- Tryptase's potent mitogenic effects in human airway smooth muscle cells are via nonproteolytic actions.
- Divergent Inhibitor Susceptibility among Airway Lumen-Accessible Tryptic Proteases.
- Mast Cells Present Protrusions into Blood Vessels upon Tracheal Allergen Challenge in Mice.
- Nonbronchoscopic bronchoalveolar lavage for the diagnosis for Pneumocystis carinii pneumonia in the acquired immunodeficiency syndrome.
- Enkephalinase inhibitors potentiate substance P-induced secretion of 35SO4-macromolecules from ferret trachea.
- Dog tracheal epithelial cells in culture synthesize sulfated macromolecular glycoconjugates and release them from the cell surface upon exposure to extracellular prote...
- Expression and function of proteinase-activated receptor 2 in human bronchial smooth muscle.
- Tissue-selective mast cell reconstitution and differential Lung gene expression in mast cell-deficient Kit(W-sh)/Kit(W-sh) sash mice.
- Dipeptidyl peptidase I is essential for activation of mast cell chymases, but not tryptases, in mice.
- Mast cell tissue inhibitor of metalloproteinase-1 is cleaved and inactivated extracellularly by alpha-chymase.
- Mast cell tryptase activates extracellular-regulated kinases (p44/p42) in airway smooth-muscle cells: importance of proteolytic events, time course, and role in mediat...
- Angiotensin II generation by mast cell alpha- and beta-chymases.
- Characterization of human gamma-tryptases, novel members of the chromosome 16p mast cell tryptase and prostasin gene families.
- Dipeptidyl peptidase I cleaves matrix-associated proteins and is expressed mainly by mast cells in normal dog airways.
- Agonists of proteinase-activated receptor 2 induce inflammation by a neurogenic mechanism.
- Proteinase-activated receptor-2 in human skin: tissue distribution and activation of keratinocytes by mast cell tryptase.
- Inflammatory mast cells up-regulate angiogenesis during squamous epithelial carcinogenesis.
- Thrombin and mast cell tryptase regulate guinea-pig myenteric neurons through proteinase-activated receptors-1 and -2.
- Mast cell expression of gelatinases A and B is regulated by kit ligand and TGF-beta.
- Clustering of activating mutations in c-KIT's juxtamembrane coding region in canine mast cell neoplasms.
- Characterization of genes encoding known and novel human mast cell tryptases on chromosome 16p13.3.
- Neutrophil elastase and elastase-rich cystic fibrosis sputum degranulate human eosinophils in vitro.
- Porcine origin of human sputum trypsin?
- Regulated expression, processing, and secretion of dog mast cell dipeptidyl peptidase I.
- Mast cell chymase-like protease(s) modulates Escherichia coli lipopolysaccharide-induced vasomotor dysfunction in skeletal muscle in vivo.
- Cloning and expression of the dog mast cell alpha-chymase gene.
- Canine mast cell adenosine receptors: cloning and expression of the A3 receptor and evidence that degranulation is mediated by the A2B receptor.
- Dog mast cell alpha-chymase activates progelatinase B by cleaving the Phe88-Gln89 and Phe91-Glu92 bonds of the catalytic domain.
- Mast cell tryptase regulates rat colonic myocytes through proteinase-activated receptor 2.
- Of mites and men: trypsin-like proteases in the Lungs.
- Purification and characterization of defensins from cystic fibrosis sputum.
- Mast cell tryptase potentiates histamine-induced contraction in human sensitized bronchus.
- Classical second messengers are not involved in proteinase-induced degranulation of airway gland cells.
- Mast cell tryptase: hoisted by its own petard?
- Dog mastocytoma cells secrete a 92-kD gelatinase activated extracellularly by mast cell chymase.
- The human mast cell chymase gene (CMA1): mapping to the cathepsin G/granzyme gene cluster and lineage-restricted expression.
- Bis(5-amidino-2-benzimidazolyl)methane and related amidines are potent, reversible inhibitors of mast cell tryptases.
- Should alpha 1-antitrypsin-deficient patients with emphysema continue to receive alpha 1-antitrypsin after Lung transplantation?
- Mast cell and neutrophil expression of dog mast cell protease-3. A novel tryptase-related serine protease.
- Modulation of thrombin and thrombin receptor peptide mitogenicity by human Lung mast cell tryptase.
- Serine proteinases of mast cell and leukocyte granules. A league of their own.
- Tryptase-induced mitogenesis in airway smooth muscle cells. Potency, mechanisms, and interactions with other mast cell mediators.
- Purification and characterization of dog mast cell protease-3, an oligomeric relative of tryptases.
- Tryptase, the dominant secretory granular protein in human mast cells, is a potent mitogen for cultured dog tracheal smooth muscle cells.
- Arachidonate 15-lipoxygenase (omega-6 lipoxygenase) from human leukocytes. Purification and structural homology to other mammalian lipoxygenases.
- Arachidonate 15-lipoxygenase from human eosinophil-enriched leukocytes: partial purification and properties.
- Mast cell chymase potentiates histamine-induced wheal formation in the skin of ragweed-allergic dogs.
- Dog mast cell chymase: molecular cloning and characterization.
- Protease inhibitors potentiate smooth muscle relaxation induced by vasoactive intestinal peptide in isolated human bronchi.
- Human mast cell tryptase: multiple cDNAs and genes reveal a multigene serine protease family.
- Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells.
- Tryptase and chymase in dog mast cells.
- Structure, chromosomal assignment, and deduced amino acid sequence of a human gene for mast cell chymase.
- The structure and airway biology of mast cell proteinases.
- Mast cell exocytosis: evidence that granule proteoglycan processing is not coupled to degranulation.
- Mast cell tryptase is a mitogen for cultured fibroblasts.
- Degradation of airway neuropeptides by human Lung tryptase.
- Human tryptase as a potent, cell-specific mitogen: role of signaling pathways in synergistic responses.
- Distribution of chymase-containing mast cells in human bronchi.
- Mast cell proteoglycans modulate the secretagogue, proteoglycanase, and amidolytic activities of dog mast cell chymase.
- Effect of phenytoin (DPH) treatment on methoxyflurane metabolism in rats.
- Proteolytic inactivation of dog Lung surfactant-associated proteins by neutrophil elastase.
Schools
Stanford University
Pennsylvania Hospital
University Calif
Conditions Treated
- Asthma
- Bronchiectasis
- COPD (Chronic Obstructive Pulmonary Disease)
- Lung Cancer
- View All
Doctors Specialties
- Pulmonology
Accepted Insurances
- CHAMPVA
- GEHA
- Medicare Advantage PFFS
- Mail Handlers Benefit Plan (MHBP)
- Medicare MCR
- United Healthcare
Awards
- Elected Member
Education
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Pennsylvania Hospital - University of Pennsylvania Health System -
Stanford University School of Medicine
Hospital
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San Francisco VA Medical Center -
UCSF Medical Center
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