Physician
Pediatrics
Dr. Gary Posner, MD
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Gary Posner works in the field of Pediatrics. He studied medicine at State University of New York Downstate Medical Center College of Medicine. Doctor Gary Posner, MD has written publications. He has 100 publications published with PubMed. The lastest paper is: 'Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family.' Gary Posner accepts Medicare payments and is registered with Medicare.gov.
Publications
- Antimalarial chemotherapy: Orally curative artemisinin-derived trioxane dimer esters.
- Antimalarial chemotherapy: Artemisinin-derived dimer carbonates and thiocarbonates.
- The survival times of malaria-infected mice are prolonged more by several new two-carbon-linked artemisinin-derived dimer carbamates than by the trioxane antimalarial ...
- A THIAZOLE DERIVATIVE OF ARTEMISININ MODERATELY REDUCES TOXOPLASMA GONDII CYST BURDEN IN INFECTED MICE.
- In vitro combination of anti-Cytomegalovirus compounds acting through different targets -- role of the slope parameter and insights into mechanisms of action.
- Unique and highly selective anticytomegalovirus activities of artemisinin-derived dimer diphenyl phosphate stem from combination of dimer unit and a diphenyl phosphate...
- Artemisinin-derived dimer phosphate esters as potent anti-cytomegalovirus (anti-CMV) and anti-cancer agents: A structure-activity study.
- Synthesis and Antimalarial Efficacy of Two-Carbon-Linked, Artemisinin-Derived Trioxane Dimers in Combination with Known Antimalarial Drugs.
- Artemisinin-derived dimers have greatly improved anti-cytomegalovirus activity compared to artemisinin monomers.
- Iron(II)-induced degradation of antimalarial beta-sulfonyl endoperoxides: evidence for the generation of potentially cytotoxic carbocations.
- A non-calcemic sulfone version of the vitamin D(3) analogue seocalcitol (EB 1089): chemical synthesis, biological evaluation and potency enhancement of the anticancer ...
- Antimalarial simplified 3-aryltrioxanes: synthesis and preclinical efficacy/toxicity testing in rodents.
- A non-calcemic analog of 1 alpha,25 dihydroxy vitamin D(3) (JKF) upregulates the induction of creatine kinase B by 17 beta estradiol in osteoblast-like ROS 17/2.8 cell...
- Conformationally restricted hybrid analogues of the hormone 1 alpha,25-dihydroxyvitamin D(3): design, synthesis, and biological evaluation.
- A rationale for treatment of hereditary vitamin D-resistant rickets with analogs of 1 alpha,25-dihydroxyvitamin D(3).
- Cancer chemoprevention using natural vitamin D and synthetic analogs.
- Examination of structurally selective derivatization of vitamin D(3) analogues by electrospray mass spectrometry.
- Metabolites and analogs of 1alpha,25-dihydroxyvitamin D(3): evaluation of actions in bone.
- Synthesis, antimalarial activity, biomimetic iron(II) chemistry, and in vivo metabolism of novel, potent C-10-phenoxy derivatives of dihydroartemisinin.
- Conceptually new 20-epi-22-oxa sulfone analogues of the hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and biological evaluation.
- Antimalarial sulfide, sulfone, and sulfonamide trioxanes.
- Conceptually new deltanoids (vitamin D analogs) inhibit multistage skin tumorigenesis.
- Antimalarial, antiproliferative, and antitumor activities of artemisinin-derived, chemically robust, trioxane dimers.
- Biological effects of 1alpha-hydroxy- and 1beta-(hydroxymethyl)-vitamin D compounds relevant for potential colorectal cancer therapy.
- Conceptually new sulfone analogues of the hormone 1alpha, 25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation.
- Physiological importance of the 1,25(OH)2D3 membrane receptor and evidence for a membrane receptor specific for 24,25(OH)2D3.
- 1,25-(OH)2D3 modulates growth plate chondrocytes via membrane receptor-mediated protein kinase C by a mechanism that involves changes in phospholipid metabolism and th...
- Orally active, hydrolytically stable, semisynthetic, antimalarial trioxanes in the artemisinin family.
- Synthesis and in vitro antimalarial activity of sulfone endoperoxides.
- Noncalcemic, antiproliferative, transcriptionally active, 24-fluorinated hybrid analogues of the hormone 1alpha, 25-dihydroxyvitamin D3. Synthesis and preliminary biol...
- Antimalarial cyclic peroxy ketals.
- Effects of the sulforaphane analog compound 30, indole-3-carbinol, D-limonene or relafen on glutathione S-transferases and glutathione peroxidase of the rat digestive ...
- Differential use of transcription activation function 2 domain of the vitamin D receptor by 1,25-dihydroxyvitamin D3 and its A ring-modified analogs.
- Design, synthesis, derivatization, and structure-activity relationships of simplified, tricyclic, 1,2,4-trioxane alcohol analogues of the antimalarial artemisinin.
- Orally active antimalarial 3-substituted trioxanes: new synthetic methodology and biological evaluation.
- Trioxane dimers have potent antimalarial, antiproliferative and antitumor activities in vitro.
- Hybrid structural analogues of 1,25-(OH)2D3 regulate chondrocyte proliferation and proteoglycan production as well as protein kinase C through a nongenomic pathway.
- A-ring analogues of 1, 25-(OH)2D3 with low affinity for the vitamin D receptor modulate chondrocytes via membrane effects that are dependent on cell maturation.
- A 20-epi side chain restores growth-regulatory and transcriptional activities of an A ring-modified hybrid analog of 1 alpha, 25-dihydroxyvitamin D3 without increasing...
- Antimalarial activity of artemisinin (qinghaosu) and related trioxanes: mechanism(s) of action.
- New vitamin D analogues.
- Design and synthesis of bifunctional isothiocyanate analogs of sulforaphane: correlation between structure and potency as inducers of anticarcinogenic detoxication enz...
- Mechanism-based design, synthesis, and in vitro antimalarial testing of new 4-methylated trioxanes structurally related to artemisinin: the importance of a carbon-cent...
- New, antimalarial, tricyclic 1,2,4-trioxanes: evaluations in mice and monkeys.
- Anticarcinogenic activities of sulforaphane and structurally related synthetic norbornyl isothiocyanates.
- Vitamin D3 analogs stimulate calcium currents in rat osteosarcoma cells.
- Structure-activity relationships of lactone ring-opened analogs of the antimalarial 1,2,4-trioxane artemisinin.
- Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.
- 1 alpha,25-dihydroxyvitamin D3 analogs featuring aromatic and heteroaromatic rings: design, synthesis, and preliminary biological testing.
- Specificity of chemiluminescence in the metabolism of benzo[a]pyrene to its carcinogenic diol epoxide.
- A chemiluminescence assay specific for the microsomal metabolite, benzo[a]pyrene-7,8-dihydrodiol.
- A chemiluminescent probe specific for singlet oxygen.
- Chemiluminescent probes for singlet oxygen in biological reactions.
- Microsomal chemiluminescence of benzo[a]pyrene-7,8-dihydrodiol and its synthetic analogues trans- and cis-1-methoxyvinylpyrene.
- Extraordinarily potent antimalarial compounds: new, structurally simple, easily synthesized, tricyclic 1,2,4-trioxanes.
- A major inducer of anticarcinogenic protective enzymes from broccoli: isolation and elucidation of structure.
- Spectroscopic quantitation of organic isothiocyanates by cyclocondensation with vicinal dithiols.
- New vitamin D3 derivatives with unexpected antiproliferative activity: 1-(hydroxymethyl)-25-hydroxyvitamin D3 homologs.
- Alkylation of enolate ions generated regiospecifically via organocopper reactions. Synthesis of decalin sesquiterpene valerane and of prostaglandin model systems.
- A covalent fluorescence probe based on excited-state proton transfer.
- Second-generation antimalarial endoperoxides.
- 1,25-Dihydroxyvitamin D and three low-calcemic analogs decrease UV-induced DNA damage via the rapid response pathway.
- Membranal effects of phytoestrogens and carboxy derivatives of phytoestrogens on human vascular and bone cells: new insights based on studies with carboxy-biochanin A.
- Vitamin D analogs as anti-carcinogenic agents.
- Systemic treatments with the low-calcemic 1,25(OH)(2)D(3) analogs JKF or QW increase both the morphological and biochemical responses to estradiol-17beta in rat tibiae.
- Less-calcemic vitamin D analogs enhance creatine kinase specific activity and modulate responsiveness to gonadal steroids in rat skeletal tissues.
- Vitamin D analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cells.
- The response of creatine kinase specific activity in rat pituitary to estrogenic compounds and vitamin d less-calcemic analogs.
- Skin cancer prevention: a possible role of 1,25dihydroxyvitamin D3 and its analogs.
- The effects of native and synthetic estrogenic compounds as well as vitamin D less-calcemic analogs on adipocytes content in rat bone marrow.
- Vitamin D metabolites and analogs induce lipoxygenase mRNA expression and activity as well as reactive oxygen species (ROS) production in human bone cell line.
- Mutual interaction of special phytoestrogenic compounds, their synthetic carboxy-derivatives and the less-calcemic vitamin D analog activities in human derived female ...
- Sequential Michael-Michael-aldol additions for easy, one-pot, 2 + 2 + 2 construction of polyfunctionalized cyclohexanols.
- Correction to Malaria-Infected Mice Are Completely Cured by One 6 mg/kg Oral Dose of a New Monomeric Trioxane Sulfide Combined with Mefloquine.
- Malaria-infected mice are completely cured by one 6 mg/kg oral dose of a new monomeric trioxane sulfide combined with mefloquine.
- An artemisinin-derived dimer has highly potent anti-cytomegalovirus (CMV) and anti-cancer activities.
- Cyanocuprates convert carboxylic acids directly into ketones.
- Three-component, one-flask synthesis of rhodanines (thiazolidinones).
- Highly stereocontrolled and regiocontrolled syntheses of 2,3,4-trisubstituted alkanoates and lactones.
- Recombinant luciferase-expressing human cytomegalovirus (CMV) for evaluation of CMV inhibitors.
- A single, low, oral dose of a 5-carbon-linked trioxane dimer orthoester plus mefloquine cures malaria-infected mice.
- ?-Chloro-?,?-ethylenic esters: enantiocontrolled synthesis and substitutions.
- Apc(MIN) modulation of vitamin D secosteroid growth control.
- A-ring hydroxymethyl 19-nor analogs of the natural hormone 1alpha,25-dihydroxyvitamin D(3): synthesis and preliminary biological evaluation.
- Asymmetric, organocatalytic, three-step synthesis of alpha-hydroxy-(E)-beta,gamma-unsaturated esters.
- Thiazole, oxadiazole, and carboxamide derivatives of artemisinin are highly selective and potent inhibitors of Toxoplasma gondii.
- Vitamin D analogues targeting CYP24 in chronic kidney disease.
- Malaria-infected mice live until at least day 30 after a new monomeric trioxane combined with mefloquine are administered together in a single low oral dose.
- ''Novel alkyl side chain sulfone 1alpha,25-dihydroxyvitamin D3 analogs: a comparison of in vitro antiproliferative activities and in vivo calcemic activities''.
- Malaria-infected mice are cured by a single oral dose of new dimeric trioxane sulfones which are also selectively and powerfully cytotoxic to cancer cells.
- Vitamin D receptor modulates the neoplastic phenotype through antagonistic growth regulatory signals.
- Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent.
- Artemisinin derivatives inhibit Toxoplasma gondii in vitro at multiple steps in the lytic cycle.
- Asymmetric, organocatalytic, three-step synthesis of gamma-hydroxy-(E)-alpha,beta-unsaturated sulfones and esters.
- Effect of artemisinins and other endoperoxides on nitric oxide-related signaling pathway in RAW 264.7 mouse macrophage cells.
- Electronically stabilized versions of the antimalarial acetal trioxanes artemether and artesunate.
- Malaria-infected mice are cured by oral administration of new artemisinin derivatives.
- Low-calcemic, highly antiproliferative, 23-oxa ether analogs of the natural hormone 1 alpha,25-dihydroxyvitamin D3: design, synthesis, and preliminary biological evalu...
- Differentiation-inducing potency of the seco-steroid JK-1624F2-2 can be increased by combination with an antioxidant and a p38MAPK inhibitor which upregulates the JNK ...
Schools
SUNY Downstate Medical Center College Of Medicine
L a Co Usc Med Center
Doctors Specialties
- Pediatrics
Accepted Insurances
Education
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University of Southern California - LAC+USC Medical Center -
State University of New York Downstate Medical Center College of Medicine
Hospital
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LAC-Olive View-UCLA Medical Center
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