Associate Professor, Immunology, Allergy and Rheumatology, Baylor College of Medicine
Allergy & Immunology
Dr. Frank M. Orson, MD
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Dr. Frank M. Orson practices Allergy & Immunology. He studied medicine at Baylor College of Medicine. He received 1 awards: "Fellow (FAAAAI)". Frank Orson is also a published doctor. He has 63 paper published. The most recent paper is: Triple helix formation: binding avidity of acridine-conjugated AG motif third strands containing natural, modified and surrogate bases opposed to pyrimidine interrupti...
Publications
- Altered methamphetamine place conditioning in mice vaccinated with a succinyl-methamphetamine-tetanus-toxoid vaccine.
- Attenuation of cocaine-induced locomotor activity in male and female mice by active immunization.
- The future potential for cocaine vaccines.
- Vaccine for cocaine dependence: A randomized double-blind placebo-controlled efficacy trial.
- A morphine conjugate vaccine attenuates the behavioral effects of morphine in rats.
- A vaccine against methamphetamine attenuates its behavioral effects in mice.
- Vaccines against stimulants: Cocaine and Methamphetamine.
- Prospects, promise and problems on the road to effective vaccines and related therapies for substance abuse.
- Spontaneous Development of IgM Anti-Cocaine Antibodies in Habitual Cocaine Users: Effect on IgG Antibody Responses to a Cocaine Cholera Toxin B Conjugate Vaccine.
- Probing cocaine-antibody interactions in buffer and human serum.
- Delayed diagnosis of hereditary angioedema.
- Active immunotherapy for the Treatment of Cocaine Dependence.
- Cocaine vaccine for the treatment of cocaine dependence in methadone-maintained patients: a randomized, double-blind, placebo-controlled efficacy trial.
- Vaccines for cocaine abuse.
- Substance abuse vaccines.
- The future of vaccines in the management of addictive disorders.
- Hepatocyte growth factor gene transfer to alveolar septa for effective suppression of lung fibrosis.
- Intravenous immunoglobulin therapy suppresses manifestations of the angioedema with hypereosinophilia syndrome.
- Topical gene therapy for pulmonary diseases with PEI-DNA aerosol complexes.
- Targeted delivery of expression plasmids to the lung via macroaggregated polyethylenimine-albumin conjugates.
- Vaccines against drug abuse.
- Various factors (allergen nature, mouse strain, CpG/recombinant protein expressed) influence the immune response elicited by genetic immunization.
- Gene delivery to the lung using protein/polyethylenimine/plasmid complexes.
- Aerosol delivery of robust polyethyleneimine-DNA complexes for gene therapy and genetic immunization.
- Genetic immunization with lung-targeting macroaggregated polyethyleneimine-albumin conjugates elicits combined systemic and mucosal immune responses.
- Role of endogenous endonucleases and tissue site in transfection and CpG-mediated immune activation after naked DNA injection.
- Triple helix formation: binding avidity of acridine-conjugated AG motif third strands containing natural, modified and surrogate bases opposed to pyrimidine interrupti...
- Comparison of triple helix formation by polypurine versus polypyrimidine oligodeoxynucleotides when conjugated to a DNA intercalator.
- A 15-base acridine-conjugated oligodeoxynucleotide forms triplex DNA with its IL-2R alpha promoter target with greatly improved avidity.
- Sequence-specific binding and cleavage of duplex DNA by a radioiodinated, intercalator-linked, triplex-forming oligonucleotide.
- Linkage structures strongly influence the binding cooperativity of DNA intercalators conjugated to triplex forming oligonucleotides.
- Photodocumentation of UV shadowing with DNA gels.
- Anti-mu antibody stimulates the phosphatidylinositol cycle and immunoglobulin secretion in a human lymphoblastoid B-cell line, LA350.
- Abnormalities of immunoregulation in juvenile rheumatoid arthritis.
- HIV-1-stimulated expression of CD11/CD18 integrins and ICAM-1: a possible mechanism for extravascular dissemination of HIV-1-infected cells.
- Interleukin 2 receptor expression by T cells in human aging.
- Modulation of a human lymphoblastoid B cell line by cyclic AMP. Ig secretion and phosphatidylcholine metabolism.
- Hybrids from fusion of normal human T lymphocytes with immortal human cells exhibit limited life span.
- Oligonucleotide inhibition of IL2R alpha mRNA transcription by promoter region collinear triplex formation in lymphocytes.
- Cyclic AMP-mediated modulation of immunoglobulin production in B cells by prostaglandin E1.
- Soluble interleukin-2 receptors in children with Kawasaki syndrome.
- Inhibition of transcription of HIV-1 in infected human cells by oligodeoxynucleotides designed to form DNA triple helices.
- Suppressor T cells and autoimmune disease.
- Regulatory mechanisms in cell-mediated immune responses. VI. Interaction of H-2 and non-H-2 genes in elaboration of mixed leukocyte reaction suppressor factor.
- Glucocorticosteroids stimulate polyclonal immunoglobulin production by cord blood mononuclear cells.
- T cell-replacing factor for glucocorticosteroid-induced immunoglobulin production. A unique steroid-dependent cytokine.
- Human peripheral blood monocytes release a 30,000 dalton factor (30 KD MF) that stimulates immunoglobulin production by activated B cells.
- Chronic Morganella morganii arthritis in an elderly patient.
- Glucocorticosteroid-induced immunoglobulin production requires intimate contact between B cells and monocytes.
- Phorbol ester binding to a human lymphoblastoid B-cell line, LA350, stimulates 32P incorporation into selected phospholipids and immunoglobulin secretion.
- T cell replacing factor for steroids (TRF-S): a 40,000 dalton protein produced by a T4+ T cell.
- Abnormalities of immunoregulation in Kawasaki syndrome.
- Seizures and dermatitis after exposure to caprolactam.
- Isolation and characterization of two complete Ara h 2 isoforms cDNA.
- Non-viral gene delivery to the lungs.
- Enhancement of both cellular and humoral responses to genetic immunization by co-administration of an antigen-expressing plasmid and a plasmid encoding the pro-apoptot...
- Protection against influenza infection by cytokine-enhanced aerosol genetic immunization.
- Monocyte CD49e and 110-120 kDa fibronectin fragments: HIV prognostic indicators independent of viral load and CD4 T-cell counts.
- Anti-drug vaccines to treat substance abuse.
- The concept of pharmacologic cocaine interception as a treatment for drug abuse.
- Anti-cocaine vaccine development.
- Anti-addiction vaccines.
Schools
Baylor University
St Lukes Episcopal Hospital
Baylor
National Institute Of Health
Doctors Specialties
- Internal Medicine
- Allergy
- Immunology
Accepted Insurances
Awards
- Fellow (FAAAAI)
Education
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National Institutes of Health Clinical Center -
Baylor College of Medicine
Hospital
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Michael E. DeBakey Veterans Affairs Medical Center
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