Professor of Medicine, Case West Res University
Gastroenterology
Dr. Fabio Cominelli, MD
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Dr. Fabio Cominelli works in the field of Gastroenterology. He received 2 awards: "America's Top Doctors" and "Elected Member". Fabio Cominelli is also published. He has 99 publications published. The lastest publication: "Treatment of Crohn's disease at the turn of the century.' He accepts Medicare.
Publications
- Colitis-associated and sporadic colon Cancers: different diseases, different mutations?
- IL-33 Interleukin-33 Drives Eosinophil Infiltration and Pathogenic Type 2 Helper T-Cell Immune Responses Leading to Chronic Experimental Ileitis.
- SAMP1/YitFc Mice Develop Ileitis via Loss of CCL21 and Defects in Dendritic Cell Migration.
- Ulcerative Colitis: What is the Optimal Treatment Goal and How Do We Achieve It?
- Targeting leukocyte trafficking for the treatment of inflammatory bowel Disease.
- Cytokines and mucosal immunity.
- Occurrence of Spontaneous Periodontal Disease in the SAMP1/YitFc Murine Model of Crohn's Disease.
- Functional defects in NOD2 signaling in experimental and human Crohn Disease.
- The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine System in intestinal inflammation.
- RIP2 activity in inflammatory Disease and implications for novel therapeutics.
- Dysregulated NOD2 predisposes SAMP1/YitFc mice to chronic Intestinal inflammation.
- Vercirnon for the treatment of Crohn's Disease.
- Probiotic Bacteria Regulate Intestinal Epithelial Permeability in Experimental Ileitis by a TNF-Dependent Mechanism.
- New insights into the dichotomous role of innate cytokines in gut homeostasis and inflammation.
- Tregs are dysfunctional in vivo in a spontaneous murine model of Crohn's Disease.
- A multicenter retrospective experience of infliximab in Crohn's Disease patients: infusion reaction rates and treatment persistency.
- Spontaneous, Immune-Mediated Gastric Inflammation in SAMP1/YitFc Mice, a Model of Crohn's-Like Gastritis.
- SAMP1/YitFc mouse strain: a spontaneous model of Crohn's Disease-like ileitis.
- Beta7 integrin deficiency suppresses B cell homing and attenuates chronic ileitis in SAMP1/YitFc mice.
- Probiotics promote gut health through stimulation of epithelial innate immunity.
- Emerging drugs for the treatment of Ulcerative colitis.
- Leukocytapheresis in Ulcerative colitis: a possible alternative to biological therapy?
- AGA Institute Future Trends Committee report: the future of gastroenterology training programs in the United States.
- Commensal bacteria and "oncologic surveillance": suggestions from an experimental model.
- Innate and adaptive Immune responses related to IBD pathogenesis.
- Early and late gut Immune responses in IBD.
- A CD8+/CD103high T cell subset regulates TNF-mediated chronic murine ileitis.
- MNK kinases regulate multiple TLR pathways and innate proinflammatory cytokines in macrophages.
- Resistin-like molecule beta (RELMbeta/FIZZ2) is highly expressed in the ileum of SAMP1/YitFc mice and is associated with initiation of ileitis.
- Immunopathogenesis of inflammatory bowel Disease: current concepts.
- Report of the American Gastroenterological Association (AGA) Institute Obesity Task Force.
- Cloning IL-1 and the birth of a new era in cytokine biology.
- Probiotics in experimental and human inflammatory bowel Disease: discussion points.
- The attrition of young physician-scientists: problems and potential solutions.
- Commensal bacteria exacerbate Intestinal inflammation but are not essential for the development of murine ileitis.
- Cytokine therapy for Crohn's Disease: advances in translational research.
- Antibody blockade of CCL25/CCR9 ameliorates early but not late chronic murine ileitis.
- Discovering the cause of inflammatory bowel Disease: lessons from animal models.
- Absence of bacterially induced RELMbeta reduces injury in the dextran sodium sulfate model of colitis.
- Role of interleukin 6 in a murine model of Crohn''s ileitis: are cytokine/anticytokine strategies the future for IBD therapies?
- Do patient preferences influence decisions on treatment for patients with steroid-refractory Ulcerative colitis?
- Novel strategies to attenuate immune activation in Crohn''s Disease.
- Role of TL1A and its receptor DR3 in two models of chronic murine ileitis.
- Critical role of endothelial P-selectin glycoprotein ligand 1 in chronic murine ileitis.
- The primary defect in experimental ileitis originates from a nonhematopoietic source.
- Targeting mucosal addressin cellular adhesion molecule (MAdCAM)-1 to noninvasively image experimental Crohn's Disease.
- New concepts in the pathophysiology of inflammatory bowel Disease.
- Activation of A2A adenosine receptor attenuates intestinal inflammation in animal models of inflammatory bowel Disease.
- Altered epithelial cell lineage allocation and global expansion of the crypt epithelial stem cell population are associated with ileitis in SAMP1/YitFc mice.
- Proinflammatory effects of TH2 cytokines in a murine model of chronic small Intestinal inflammation.
- A randomized, double-blind, placebo-controlled trial of CDP571, a humanized monoclonal antibody to tumour necrosis factor-alpha, in patients with corticosteroid-depend...
- L-selectin, alpha 4 beta 1, and alpha 4 beta 7 integrins participate in CD4+ T cell recruitment to chronically inflamed small intestine.
- Linkage to peroxisome proliferator-activated receptor-gamma in SAMP1/YitFc mice and in human Crohn''s Disease.
- Cytokine-based therapies for Crohn's Disease--new paradigms.
- Expanded B cell population blocks regulatory T cells and exacerbates ileitis in a murine model of Crohn Disease.
- Differential contribution of IL-1Ra isoforms to allele-specific IL-1Ra mRNA accumulation.
- Optimal dosing of 5-aminosalicylic acid: 5 decades of choosing between politicians.
- Effect of Digestive health care services integration on resource use and outcomes in patients with Digestive disorders.
- The Th1 immune pathway as a therapeutic target in Crohn''s Disease.
- Future therapies for inflammatory bowel Disease.
- Expression, localization, and functional activity of TL1A, a novel Th1-polarizing cytokine in inflammatory bowel Disease.
- Identification of a quantitative trait locus for ileitis in a spontaneous mouse model of Crohn's Disease: SAMP1/YitFc.
- TNF-alpha neutralization ameliorates the severity of murine Crohn's-like ileitis by abrogation of Intestinal epithelial cell apoptosis.
- Mouse models for the study of Crohn''s Disease.
- Emergence of perianal fistulizing Disease in the SAMP1/YitFc mouse, a spontaneous model of chronic ileitis.
- Genetic dissection of the cellular pathways and signaling mechanisms in modeled tumor necrosis factor-induced Crohn's-like inflammatory bowel Disease.
- Down-regulation of intestinal lymphocyte activation and Th1 cytokine production by antibiotic therapy in a murine model of Crohn's Disease.
- Effect of misoprostol on ibuprofen-induced renal dysfunction in patients with decompensated Cirrhosis: results of a double-blind placebo-controlled parallel group study.
- A possible role of IL-1ra 3'-untranslated region in modulation of protein production.
- Intestinal ischemia and peripheral gangrene in a patient with chronic renal failure.
- Antibody blockade of ICAM-1 and VCAM-1 ameliorates inflammation in the SAMP-1/Yit adoptive transfer model of Crohn's Disease in mice.
- A ''minimal'' approach in design of flavivirus infectious DNA.
- The incidence of lymphoid and myeloid malignancies among hospitalized Crohn's Disease patients.
- Cost-utility of initial medical management for Crohn's Disease perianal fistulae.
- A new strategy in design of +RNA virus infectious clones enabling their stable propagation in E. coli.
- Th1-type responses mediate spontaneous ileitis in a novel murine model of Crohn's Disease.
- Recombinant interleukin 10 for the treatment of active Crohn's Disease: lessons in biologic therapy.
- Lessons from genetically engineered animal models XI. Novel mouse models to study pathogenic mechanisms of Crohn's Disease.
- The relationship between infliximab treatment and lymphoma in Crohn's Disease.
- Functional and ethnic association of allele 2 of the interleukin-1 receptor antagonist gene in Ulcerative colitis.
- IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's Disease: expression and localization in intestinal mucosal cells.
- Impaired on/off regulation of TNF biosynthesis in mice lacking TNF AU-rich elements: implications for joint and gut-associated immunopathologies.
- Treatment of Crohn's Disease at the turn of the century.
- Proinflammatory cytokines differentially modulate their own expression in human Intestinal mucosal mesenchymal cells.
- Inflammatory bowel Disease: short- and long-term treatments.
- Hyponatremia of Cirrhosis: role of vasopressin and decreased ''effective'' plasma volume.
- Interleukin-1 receptor antagonist: a "novel" acute phase protein with antiinflammatory activities.
- A new syndrome of Crohn's Disease and pachydermoperiostosis in a family.
- Interleukin-1 and interleukin-1 receptor antagonist in inflammatory bowel Disease.
- A randomized double-blind comparison of placebo, etodolac, and naproxen on gastroIntestinal injury and prostaglandin production.
- Localization of Intestinal interleukin 1 activity and protein and gene expression to lamina propria cells.
- Neutralization of endogenous IL-1 receptor antagonist exacerbates and prolongs inflammation in rabbit Immune colitis.
- Mucosal imbalance of IL-1 and IL-1 receptor antagonist in inflammatory bowel Disease. A novel mechanism of chronic intestinal inflammation.
- Anti-inflammatory effects of CGP 47969A, a novel inhibitor of proinflammatory cytokine synthesis, in rabbit Immune colitis.
- Interaction of NSAIDs and Helicobacter pylori on gastroIntestinal injury and prostaglandin production: a controlled double-blind trial.
- Rabbit interleukin-1 receptor antagonist. Cloning, expression, functional characterization, and regulation during Intestinal inflammation.
- Molecular mechanism underlying impaired platelet responsiveness in liver Cirrhosis.
- Systemic haemodynamics, renal and platelet function during chronic propranolol administration in patients with compensated cirrhosis.
Schools
University Of Florence
Procedures Preformed
- Colonoscopy, Proctosigmoidoscopy, and Sigmoidoscopy
- Endoscopy (Esophagus, Stomach, Small Intestine)
Conditions Treated
- Abdominal Pain
- Anemia
- Benign Neoplasm of the Digestive System
- Biliary Atresia
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Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- America's Top Doctors
- Elected Member
Education
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University of Florence Faculty of Medicine
Hospital
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University Hospitals Case Medical Center
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1912042904 |
| Last Name Of The Provider | COMINELLI |
| First Name Of The Provider | FABIO |
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