Professor of Pathology, UT Southwestern Medical Center

Pathology

Dennis K. Burns is an expert in the field of Pathology. He attended University of Texas Southwestern Medical School. He received 2 awards: "Super Doctor" and "Top MD". Dennis Burns is a published MD. He published 40 publications, including: 'A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females.'

Publications

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• Hepatic entrapment of esterified cholesterol drives continual expansion of whole body sterol pool in lysosomal acid lipase-deficient mice.
• Expression of MAP 2 by haemangioblastomas: an immunohistochemical study with implications for diagnosis.
• High expression of the stem cell marker nestin is an adverse prognostic factor in WHO grade II-III astrocytomas and oligoastrocytomas.
• Hippocampal sclerosis in dementia, epilepsy, and ischemic injury: differential vulnerability of hippocampal subfields.
• Somatic gain-of-function mutations in PIK3CA in patients with macrodactyly.
• A restricted cell population propagates glioblastoma growth after chemotherapy.
• Solitary liver mass in a patient with Hepatitis C.
• A sodium channel knockin mutant (NaV1.4-R669H) mouse model of hypokalemic periodic paralysis.
• Tsc1 mutant neural stem/progenitor cells exhibit migration deficits and give rise to subependymal lesions in the lateral ventricle.
• Unesterified cholesterol accumulation in late endosomes/lysosomes causes neurodegeneration and is prevented by driving cholesterol export from this compartment.
• Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.
• Progressive motor weakness in transgenic mice expressing human TDP-43.
• Fetal akinesia deformation sequence and neuroaxonal dystrophy without PLA2G6 mutation.
• Weekly cyclodextrin administration normalizes cholesterol metabolism in nearly every organ of the Niemann-Pick type C1 mouse and markedly prolongs life.
• Dystrophinopathy in girls with limb girdle muscular dystrophy phenotype.
• Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas.
• Neuroanatomic profile of polyglutamine immunoreactivity in Huntington disease brains.
• Reversal of defective lysosomal transport in NPC disease ameliorates liver dysfunction and neurodegeneration in the npc1-/- mouse.
• Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model.
• Pten haploinsufficiency accelerates formation of high-grade astrocytomas.
• Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation.
• The Werner syndrome helicase is a cofactor for HIV-1 long terminal repeat transactivation and retroviral replication.
• Inactivation of NF1 in CNS causes increased glial progenitor proliferation and optic glioma formation.
• Primary Lateral Sclerosis: Clinical and Laboratory Features in 25 Patients.
• Early inactivation of p53 tumor suppressor gene cooperating with NF1 loss induces malignant astrocytoma.
• Neurocytoma-like neoplasm of the thoracic spine in a 15-month-old child presenting with diffuse leptomeningeal dissemination and communicating hydrocephalus. Case report.
• Rabies encephalomyelitis: clinical, neuroradiological, and pathological findings in 4 transplant recipients.
• HIV-1 Tat interactions with p300 and PCAF transcriptional coactivators inhibit histone acetylation and neurotrophin signaling through CREB.
• Gene transduction in skin cells: preventing cancer in xeroderma pigmentosum mice.
• Comparative pathology of nerve sheath tumors in mouse models and humans.
• Fatal type 3 adenoviral pneumonia in immunocompetent adult identical twins.
• Benefit of IVIg for long-standing ataxic sensory neuronopathy with Sjögren's syndrome.
• Adult polyglucosan body disease associated with lewy bodies and tremor.
• Cytology of subependymoma.
• Cystic fibrosis and Chiari type I malformation: autopsy study of two infants with a rare association.
• Neurofibromas in NF1: Schwann cell origin and role of tumor environment.
• A PAX1 enhancer locus is associated with susceptibility to idiopathic scoliosis in females.
• TDP-43, an ALS Linked Protein, Regulates Fat Deposition and Glucose Homeostasis.
• Mouse models of Alzheimer's disease: a quest for plaques and tangles.

Schools

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• University of Texas Southwestern Medical Center At Dallas

• University Tex SwParkland Meml Hospital

• University Tex Sw Parkland Meml Hospital

Doctors Specialties

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• Neuropathology
• Pathology

Accepted Insurances

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Awards

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• Super Doctor
• Top MD

Education

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• University of Texas Southwestern Medical School

Hospital

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• University of Texas Southwestern Medical Center

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