Chief, Laboratory of Allergic Diseases, NIAID/NIH

Allergy & Immunology

Dean D. Metcalfe, MD is an expert in the field of Allergy & Immunology. He graduated from University of Tennessee College of Medicine. He received awards:"Super Doctor" and "Whos Who in Medicine and Healthcare". Dean Metcalfe is a published doctor. He has 15 papers published. The most current publication "Subvisible Particle Content, Formulation, and Dose of an Erythropoietin Peptide Mimetic Product Are Associated With Severe Adverse Postmarketing Events."

Publications

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• Subvisible Particle Content, Formulation, and Dose of an Erythropoietin Peptide Mimetic Product Are Associated With Severe Adverse Postmarketing Events.
• Interferon-γ enhances both the anti-bacterial and the pro-inflammatory response of human mast cells to Staphylococcus aureus.
• Abnormal bone marrow histopathology in paediatric mastocytosis.
• Rictor Negatively Regulates High-Affinity Receptors for IgE-Induced Mast Cell Degranulation.
• Functional Deregulation of KIT: Link to Mast Cell Proliferative Diseases and Other Neoplasms.
• Mastocytosis.
• A Truncated Splice-Variant of the FcεRIβ Receptor Subunit Is Critical for Microtubule Formation and Degranulation in Mast Cells.
• Prevention of F-actin assembly switches the response to SCF from chemotaxis to degranulation in human mast cells.
• Mast cell dependent vascular changes associated with an acute response to cold immersion in primary contact urticaria.
• Knockout of the Trpc1 gene reveals that TRPC1 can promote recovery from anaphylaxis by negatively regulating mast cell TNF-? production.
• A novel KIT-deficient mouse mast cell model for the examination of human KIT-mediated activation responses.
• IL-33 induces a hyporesponsive phenotype in human and mouse mast cells.
• The phosphoinositide 3-kinase-dependent activation of Btk is required for optimal eicosanoid production and generation of reactive oxygen species in antigen-stimulated...
• Growth of Human Mast Cells from Bone Marrow and Peripheral Blood-Derived CD34(+) Pluripotent Hematopoietic Cells.

Schools

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• University of Tennessee Memphis College of Medicine amp Surgery

Doctors Specialties

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• Rheumatology
• Allergy
• Immunology

Accepted Insurances

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Awards

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• Super Doctor
• Whos Who in Medicine and Healthcare

Education

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• University of Michigan Hospitals and Health Centers
• University of Tennessee College of Medicine

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