President, University of Texas Southwestern Medical Center; Professor of Internal Medicine, Southwestern Medical School
Gastroenterology
Dr. Daniel K. Podolsky, MD
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Daniel Podolsky works in the field of Gastroenterology. He graduated from Harvard Medical School. Harvard Medical School is a top medical college. Harvard Medical School has a rank of 1 in research and a 12 in primary care He has 7 awards "CMS Meaningful Use Stage 1 Certification", "Elected Member", "Distinguished Achievement Award", "Julius Friedenwald Medal", "Merit Award", "Board Member" and "Board of Directors". Doctor Daniel K. Podolsky, MD is a published MD. He published 100 publications, including: 'Detection, purification and characterization of a human cancer-associated galactosyltransferase acceptor.'
Publications
- Public reporting of patient safety metrics: ready or not?
- Gastroenterology's editors-in-chief: historical and personal perspectives of their editorships.
- Toll-like Receptor 4 Variant D299G Induces Features of Neoplastic Progression in Caco-2 Intestinal Cells and Is Associated With Advanced Human Colon Cancer.
- LRRK2 is involved in the IFN-gamma response and host response to pathogens.
- Identification of Drosophila Yin and PEPT2 as evolutionarily conserved phagosome-associated muramyl dipeptide transporters.
- MDP-NOD2 stimulation induces HNP-1 secretion, which contributes to NOD2 antibacterial function.
- TLR2 mediates gap junctional intercellular communication through connexin-43 in intestinal epithelial barrier injury.
- The cytoskeletal scaffold Shank3 is recruited to pathogen-induced actin rearrangements.
- Colitis-associated variant of TLR2 causes impaired mucosal repair because of TFF3 deficiency.
- A novel hybrid yeast-human network analysis reveals an essential role for FNBP1L in antibacterial autophagy.
- Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds.
- TNF receptor type I-dependent activation of innate responses to reduce intestinal damage-associated mortality.
- AKAP13, a RhoA GTPase-specific guanine exchange factor, is a novel regulator of TLR2 signaling.
- TLRs in the Gut. IV. Negative regulation of Toll-like receptors and intestinal homeostasis: addition by subtraction.
- Centaurin beta1 down-regulates nucleotide-binding oligomerization domains 1- and 2-dependent NF-kappaB activation.
- Toll-like receptor signaling and its relevance to intestinal inflammation.
- Th2 cytokines down-regulate TLR expression and function in human intestinal epithelial cells.
- Trypsin-sensitive modulation of intestinal epithelial MD-2 as mechanism of lipopolysaccharide tolerance.
- Case records of the Massachusetts General Hospital. Case 8-2006. A 71-year-old woman with Crohn's disease and altered mental status.
- Vangl1 protein acts as a downstream effector of intestinal trefoil factor (ITF)/TFF3 signaling and regulates wound healing of intestinal epithelium.
- Selective use of selective nonsteroidal anti-inflammatory drugs in inflammatory bowel disease.
- Selective adhesion-molecule therapy and inflammatory bowel disease--a tale of Janus?
- The effect of prior colonic imaging on endoscopic productivity: potential impact of computed tomographic colonography.
- Membrane recruitment of NOD2 in intestinal epithelial cells is essential for nuclear factor-{kappa}B activation in muramyl dipeptide recognition.
- Nucleotide-binding-oligomerization domain proteins and toll-like receptors: sensors of the inflammatory bowel diseases' microbial environment.
- GRIM-19 interacts with nucleotide oligomerization domain 2 and serves as downstream effector of anti-bacterial function in intestinal epithelial cells.
- Commensal flora: wolf in sheep's clothing.
- American Gastroenterological Association. Presidential address.
- An analysis of the potential impact of computed tomographic colonography (virtual colonoscopy) on colonoscopy demand.
- The AGA and future trends in Gastroenterology: CT colonography.
- Toll-like receptor 2 enhances ZO-1-associated intestinal epithelial barrier integrity via protein kinase C.
- Functional modulation of enterocytes by gram-positive and gram-negative microorganisms.
- Mechanisms of cross hyporesponsiveness to Toll-like receptor bacterial ligands in intestinal epithelial cells.
- Chemotherapy- and radiotherapy-induced intestinal damage is regulated by intestinal trefoil factor.
- Control freaks: immune regulatory cells.
- Interferon-gamma augments CARD4/NOD1 gene and protein expression through interferon regulatory factor-1 in intestinal epithelial cells.
- Colonic epithelial functional phenotype varies with type and phase of experimental Colitis.
- Gamma interferon augments the intracellular pathway for lipopolysaccharide (LPS) recognition in human intestinal epithelial cells through coordinated up-regulation of ...
- Intestinal myofibroblasts in innate immune responses of the intestine.
- CARD15/NOD2 functions as an antibacterial factor in human intestinal epithelial cells.
- Transforming growth factor-beta mediates intestinal healing and susceptibility to injury in vitro and in vivo through epithelial cells.
- Trefoil peptide expression and goblet cell number in rat intestine: effects of KGF and fasting-refeeding.
- Commensal-associated molecular patterns induce selective toll-like receptor-trafficking from apical membrane to cytoplasmic compartments in polarized intestinal epithe...
- TFF2/SP-deficient mice show decreased gastric proliferation, increased acid secretion, and increased susceptibility to NSAID injury.
- Role of tumor necrosis factor receptor 2 (TNFR2) in colonic epithelial hyperplasia and chronic intestinal inflammation in mice.
- Innate immunity in inflammatory bowel disease.
- Enhanced innate immune responsiveness and intolerance to intestinal endotoxins in human biliary epithelial cells contributes to chronic cholangitis.
- Functionally defective germline variants of sialic acid acetylesterase in autoimmunity.
- In vivo action of trefoil factor 2 (TFF2) to speed gastric repair is independent of cyclooxygenase.
- Synthesis of biologically active biotinylated muramyl dipeptides.
- Beyond tumor necrosis factor: next-generation biologic therapy for inflammatory bowel disease.
- Intestinal epithelial TOLLerance versus inTOLLerance of commensals.
- Evolving knowledge and therapy of inflammatory bowel disease.
- Trefoil factors: initiators of mucosal healing.
- The future of IBD treatment.
- The current future understanding of inflammatory bowel disease.
- SO(4) theory of antiferromagnetism and superconductivity in Bechgaard salts.
- Mott transition between a spin-liquid insulator and a metal in three dimensions.
- Nernst effect and diamagnetism in phase fluctuating superconductors.
- Unravelling the pathogenesis of inflammatory bowel disease.
- Toll-like receptor 2 controls mucosal inflammation by regulating epithelial barrier function.
- The role of the Toll receptor pathway in susceptibility to inflammatory bowel diseases.
- Inflammatory bowel disease 1999: present and future promises.
- Pride and prejudice: inflammatory bowel disease models and drug development.
- IBD: the dialectic of clinical advances and challenges.
- Paradoxical roles of different nitric oxide synthase isoforms in colonic injury.
- Exploring the interplay of barrier function and leukocyte recruitment in intestinal inflammation by targeting fucosyltransferase VII and trefoil factor 3.
- "For whom the bell tolls!" -- innate defense mechanisms and survival strategies of the intestinal epithelium against lumenal pathogens.
- Selective reduction of intestinal trefoil factor in untreated coeliac disease.
- Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease.
- Mitogen-activated protein kinase activation regulates intestinal epithelial differentiation.
- The trefoil gene family are coordinately expressed immediate-early genes: EGF receptor- and MAP kinase-dependent interregulation.
- Infliximab for the treatment of fistulas in patients with Crohn's disease.
- Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3.
- Effects of growth factors and trefoil peptides on migration and replication in primary oxyntic cultures.
- Goblet-cell-specific transcription of mouse intestinal trefoil factor gene results from collaboration of complex series of positive and negative regulatory elements.
- Cancer-associated serum galactosyltransferase activity. Demonstration in an animal model system.
- Detection, purification and characterization of a human cancer-associated galactosyltransferase acceptor.
- Galactosyltransferase activities in human sera: detection of a cancer-associated isoenzyme.
- Inhibition of growth of transformed cells and tumors by an endogenous acceptor of galactosyltransferase.
- Purification of galactosyltransferase "isoenzymes" I and II. Comparison of cancer-associated and normal galactosyltransferase activities.
- A cancer-associated galactosyltransferase isoenzyme.
- Role of cell membrane galactosyltransferase in concanavalin A agglutination of erythrocytes.
- The synthesis, binding, and agglutinating activity of 6-aminohexyl beta-D-mannopyranoside.
- Cancer-associated isoenzyme of serum galactosyltransferase.
- Mechanism of human lymphocyte stimulation by concanavalin A: role of valence and surface binding sites.
- Expression of vascular adhesion molecules in inflammatory bowel disease.
- Peptide growth factors: role in epithelial-lamina propria cell interactions.
- The molecular basis of colon cancer.
- Identification and characterization of rat intestinal trefoil factor: tissue- and cell-specific member of the trefoil protein family.
- Inflammatory bowel disease (1)
- Inflammatory bowel disease (2)
- Mucosal immunity and inflammation. V. Innate mechanisms of mucosal defense and repair: the best offense is a good defense.
- Glucocorticoids have pleiotropic effects on small intestinal crypt cells.
- New life in a sleeper: thalidomide and Crohn's disease.
- A paradoxical reduction in susceptibility to colonic injury upon targeted transgenic ablation of goblet cells.
- Lipopolysaccharide activates distinct signaling pathways in intestinal epithelial cell lines expressing Toll-like receptors.
- Intestinal trefoil factor confers colonic epithelial resistance to apoptosis.
- Nutrition and Crohn's disease: a case study in ambiguity.
Schools
HARVARD MED SCH
Massachusetts General Hospital
University of Texas Southwestern Medical Center President
University of Texas Southwestern Medical Center Professor Department of Internal Medicine
Conditions Treated
- Ulcerative Colitis
Doctors Specialties
- Gastroenterology
Accepted Insurances
Awards
- CMS Meaningful Use Stage 1 Certification
- Elected Member
- Distinguished Achievement Award
- Julius Friedenwald Medal
- Merit Award
- Board Member
- Board of Directors
Education
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Massachusetts General Hospital -
Harvard Medical School
Hospital
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University of Texas Southwestern Medical Center
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