Professor, Medicine, UCSF School of Medicine
Endocrinology
Dr. Daniel D. Bikle, MD
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Dr. Daniel D. Bikle is an expert in the field of Endocrinology. He graduated from University of Pennsylvania School of Medicine. He over the years received 17 awards: "Career Award in Vitamin D Research", "Boy Frame Award for Clinical Excellence in the Field of Bone and Mineral Research", "Fellowship", "Association of American Physicians", "Western Association of Physicians", "Elected Member", "National Institutes of Health Special Postdoctoral Fellowship", "Medical Scientist Fellowship", "Horatio C Wood Prize in Pharmacology", "Bordon Research Award in Medicine", "Spencer Morris Prize", "Alpha Omega Alpha Honorary Medical Society", "Baldwin Lucke Memorial Prize", "Henderson Memorial Prize in Biochemistry", "Magna Cum Laude", "National Science Foundation Summer Fellowship" and "Harvard Honorary Scholarship". Dr. Daniel D. Bikle is also published. He has 98 publications published. The lastest publication: "The Transient Role for Calcium and Vitamin D During the Developmental Hair Follicle Cycle.'
Publications
- Role of IGF-I signaling in muscle bone interactions.
- Antitumor Activity of 3-Indolylmethanamines 31B and PS121912.
- Highlights from the 17th workshop on vitamin d, chicago, IL, june 17-21, 2014.
- Total 25(OH) vitamin D, free 25(OH) vitamin D and markers of bone turnover in cirrhotics with and without synthetic dysfunction.
- UVB induces epidermal 11β-hydroxysteroid dehydrogenase type 1 activity in vivo.
- Osteoblast-Specific Loss of IGF1R signaling Results in Impaired Endochondral Bone Formation during Fracture Healing.
- Gender specific differences in the skeletal response to continuous PTH in mice lacking the IGF1 receptor in mature osteoblasts.
- Novel mechanisms for the vitamin D receptor (VDR) in the skin and in skin cancer.
- Anticancer activity of VDR-coregulator inhibitor PS121912.
- Evidence That Loss-of-Function Filaggrin Gene Mutations Evolved in Northern Europeans to Favor Intracutaneous Vitamin D3 Production.
- Calcium, orai1, and epidermal proliferation.
- Vitamin D and cancer: the promise not yet fulfilled.
- Highlights from the 16th Vitamin D Workshop, San Francisco, CA, June 11-14, 2013.
- Ephrin B2/EphB4 Mediates the Actions of IGF-I Signaling in Regulating Endochondral Bone Formation.
- LncRNA: A New Player in 1α, 25(OH)2 vitaminD3 /VDR Protection against Skin Cancer Formation.
- Development of novel Vitamin D Receptor-Coactivator Inhibitors.
- Vitamin D Metabolism, Mechanism of Action, and Clinical Applications.
- A comparison of direct and calculated free 25(OH) Vitamin D levels in clinical populations.
- Insulin-like growth factor-1 receptor in mature osteoblasts is required for periosteal bone formation induced by reloading.
- Vitamin D3 Effects on Lipids Differ in Statin and Non-Statin-Treated Humans: Superiority of Free 25-OH D Levels in Detecting Relationships.
- Variability in free 25(OH) vitamin D levels in clinical populations.
- Reciprocal role of vitamin D receptor on β-catenin regulated keratinocyte proliferation and differentiation.
- Mammary-specific ablation of the calcium-sensing receptor during lactation alters maternal calcium metabolism, milk calcium transport, and neonatal calcium accrual.
- Role of the calcium-sensing receptor in calcium regulation of epidermal differentiation and function.
- Anabolic effects of IGF-1 signaling on the skeleton.
- Ceramides stimulate caspase-14 expression in human keratinocytes.
- Sex and age modify biochemical and skeletal manifestations of chronic hyperparathyroidism by altering target organ responses to Ca(2+) and PTH in mice.
- Protective actions of vitamin D in UVB induced skin cancer.
- Vitamin D in cutaneous carcinogenesis: Part I.
- Vitamin D in cutaneous carcinogenesis: Part II.
- Protective role of vitamin D signaling in skin cancer formation.
- Ablation of the calcium-sensing receptor in keratinocytes impairs epidermal differentiation and barrier function.
- 1α,25(OH)(2)-Dihydroxyvitamin D(3)/VDR protects the skin from UVB-induced tumor formation by interacting with the β-catenin pathway.
- Calcium regulation of keratinocyte differentiation.
- The Nonskeletal Effects of Vitamin D: An Endocrine Society Scientific Statement.
- Vitamin D and Bone.
- Vitamin D Receptor Mediates DNA Repair and Is UV Inducible in Intact Epidermis but Not in Cultured Keratinocytes.
- Coactivator MED1 Ablation in Keratinocytes Results in Hair-Cycling Defects and Epidermal Alternations.
- Osteoblast extracellular Ca(2+) -sensing receptor regulates bone development, mineralization and turnover.
- Skeletal unloading induced insulin-like growth factor-I (IGF-I) non-responsiveness is not shared by platelet-derived growth factor: the selective role of integrins in ...
- Vitamin D and the skin: Physiology and pathophysiology.
- Overexpression of Hedgehog Signaling Is Associated with Epidermal Tumor Formation in Vitamin D Receptor-Null Mice.
- Insulin Like Growth Factor-I: A Critical Mediator of the Skeletal Response to Parathyroid Hormone.
- Vitamin D metabolism and function in the skin.
- The calcium-sensing receptor-dependent regulation of cell-cell adhesion and keratinocyte differentiation requires rho and filamin a.
- IGF-1R Signaling in chondrocytes modulates growth plate development by interacting with the PTHrP/Ihh pathway.
- Lineage-specific effects of 1,25-dihydroxyvitamin D(3) on the development of effector CD4 T cells.
- Vitamin D regulation of immune function.
- The vitamin D receptor: a tumor suppressor in skin.
- The transcriptional coactivator DRIP/mediator complex is involved in vitamin D receptor function and regulates keratinocyte proliferation and differentiation.
- Vitamin D: newly discovered actions require reconsideration of physiologic requirements.
- Vitamin D and immune function: understanding common pathways.
- Vitamin D receptor and coactivators SRC2 and 3 regulate epidermis-specific sphingolipid production and permeability barrier formation.
- Hypercalcemia and overexpression of CYP27B1 in a patient with nephrogenic systemic fibrosis: clinical vignette and literature review.
- Phosphatidylinositol-4-phosphate 5-kinase 1alpha mediates extracellular calcium-induced keratinocyte differentiation.
- Quantification of the vitamin D receptor-coregulator interaction.
- Nonclassic actions of vitamin D.
- Vitamin D receptor, UVR, and skin cancer: a potential protective mechanism.
- Growth hormone/insulin-like growth factor-1/PTH axis in bone.
- Histone acetylation in keratinocytes enables control of the expression of cathelicidin and CD14 by 1,25-dihydroxyvitamin D3.
- Inactivation of the calcium sensing receptor inhibits E-cadherin-mediated cell-cell adhesion and calcium-induced differentiation in human epidermal keratinocytes.
- Vitamin D insufficiency/deficiency in gastrointestinal disorders.
- IGF-I receptor is required for the anabolic actions of parathyroid hormone on bone.
- Constitutive activity of the osteoblast Ca2+-sensing receptor promotes loss of cancellous bone.
- What is new in vitamin D: 2006-2007.
- Insulin-like growth factor I stimulates recovery of bone lost after a period of skeletal unloading.
- The role of the calcium sensing receptor in regulating intracellular calcium handling in human epidermal keratinocytes.
- Regulation of human epidermal keratinocyte differentiation by the vitamin D receptor and its coactivators DRIP205, SRC2, and SRC3.
- The recruitment of phosphatidylinositol 3-kinase to the E-cadherin-catenin complex at the plasma membrane is required for calcium-induced phospholipase C-gamma1 activa...
- Injury enhances TLR2 function and antimicrobial peptide expression through a vitamin D-dependent mechanism.
- Insulin-like growth factor-I is essential for embryonic bone development.
- Role of IGF-I signaling in regulating osteoclastogenesis.
- Development and progression of alopecia in the vitamin D receptor null mouse.
- Hairless suppresses vitamin D receptor transactivation in human keratinocytes.
- Calcium-induced human keratinocyte differentiation requires src- and fyn-mediated phosphatidylinositol 3-kinase-dependent activation of phospholipase C-gamma1.
- Phospholipase cgamma1 is required for activation of store-operated channels in human keratinocytes.
- Vitamin D and skin cancer.
- The effect of LXR activators on AP-1 proteins in keratinocytes.
- Vitamin D regulated keratinocyte differentiation.
- Skeletal unloading induces resistance to insulin-like growth factor-I (IGF-I) by inhibiting activation of the IGF-I signaling pathways.
- PTH differentially regulates expression of RANKL and OPG.
- Two distinct coactivators, DRIP/mediator and SRC/p160, are differentially involved in vitamin D receptor transactivation during keratinocyte differentiation.
- Human keratinocyte ATP2C1 localizes to the Golgi and controls Golgi Ca2+ stores.
- The impact of skeletal unloading on bone formation.
- Role of protein kinase C alpha in calcium induced keratinocyte differentiation: defective regulation in squamous cell carcinoma.
- Biochemical regulation of breast cancer cell expression of S1P2 (Edg-5) and S1P3 (Edg-3) G protein-coupled receptors for sphingosine 1-phosphate.
- The vitamin D response element of the involucrin gene mediates its regulation by 1,25-dihydroxyvitamin D3.
- The mechanism of 1,25-dihydroxyvitamin D(3) autoregulation in keratinocytes.
- Insulin-like growth factor I is required for the anabolic actions of parathyroid hormone on mouse bone.
- Epidermal expression of the full-length extracellular calcium-sensing receptor is required for normal keratinocyte differentiation.
- Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth.
- Ablation of coactivator med1 switches the cell fate of dental epithelia to that generating hair.
- IDENTIFICATION OF VDR ANTAGONISTS AMONG NUCLEAR RECEPTOR LIGANDS USING VIRTUAL SCREENING.
- The protective role of vitamin d signaling in non-melanoma skin cancer.
- The Transient Role for Calcium and Vitamin D During the Developmental Hair Follicle Cycle.
- Regulation of Ligand and Shear Stress-induced Insulin-like Growth Factor 1 (IGF1) Signaling by the Integrin Pathway.
- Synthesis and evaluation of vitamin D receptor-mediated activities of cholesterol and vitamin D metabolites.
Schools
Perelman School of Medicine University of Pennsylvania
Peter B Brigham Hospital
Doctors Specialties
- Internal Medicine
- Endocrinology
Accepted Insurances
Awards
- Career Award in Vitamin D Research
- Boy Frame Award for Clinical Excellence in the Field of Bone and Mineral Research
- Fellowship
- Association of American Physicians
- Western Association of Physicians
- Elected Member
- National Institutes of Health Special Postdoctoral Fellowship
- Medical Scientist Fellowship
- Horatio C Wood Prize in Pharmacology
- Bordon Research Award in Medicine
- Spencer Morris Prize
- Alpha Omega Alpha Honorary Medical Society
- Baldwin Lucke Memorial Prize
- Henderson Memorial Prize in Biochemistry
- Magna Cum Laude
- National Science Foundation Summer Fellowship
- Harvard Honorary Scholarship
Education
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University of Pennsylvania -
University of Pennsylvania School of Medicine -
Perelman School of Medicine at the University of Pennsylvania -
Harvard University
Hospital
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San Francisco VA Medical Center -
UCSF Medical Center
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