Professor and Chairman, Robert and Janice McNair Endowed Chair in Molecular and Human Genetics, Department of Molecular and Human Genetics, Baylor College of Medicine
Medical Genetics
Dr. Brendan Lee, MD
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Brendan works in the field of Medical Genetics. He attended Baylor College of Medicine. He over the years received 3 awards: "Fellow", "Elected Member" and "Fellow (FAAP)". Brendan is a published doctor as well. He has 45 publications published. The latest was: Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
Publications
- Human recombinant arginase enzyme reduces plasma arginine in mouse models of arginase deficiency.
- FBN1 contributing to familial congenital diaphragmatic hernia.
- Post-translationally Abnormal Collagens of Prolyl 3-Hydroxylase-2 Null Mice Offer a Pathobiological Mechanism for the High Myopia Linked to Human LEPREL1 Mutations.
- Early B-cell-specific inactivation of ATM synergizes with ectopic CyclinD1 expression to promote pre-germinal center B-cell lymphomas in mice.
- Losartan increases bone mass and accelerates chondrocyte hypertrophy in developing skeleton.
- The osteogenic niche promotes early-stage bone colonization of disseminated breast cancer cells.
- RECQL4 Regulates p53 Function in vivo During Skeletogenesis.
- Blood ammonia and glutamine as predictors of hyperammonemic crises in patients with urea cycle disorder.
- Exome Sequencing Identifies a Novel Homozygous Mutation in the Phosphate Transporter SLC34A1 in Hypophosphatemia and Nephrocalcinosis.
- Dual role of the trps1 transcription factor in dentin mineralization.
- Notch activation as a driver of osteogenic sarcoma.
- A transgenic mouse model of OI type V supports a neomorphic mechanism of the IFITM5 mutation.
- Sodium phenylbutyrate decreases plasma branched-chain amino acids in patients with urea cycle disorders.
- Excessive transforming growth factor-β signaling is a common mechanism in osteogenesis imperfecta.
- Connective tissue alterations in Fkbp10-/- mice.
- 0041 Cross-sectional Multicenter Study of Osteogenesis Imperfecta in North America - Results from the Linked Clinical Research Centers.
- Branched-Chain Amino Acid Metabolism: From Rare Mendelian Diseases to More Common Disorders.
- The Swaying mouse as a model of Osteogenesis Imperfecta caused by WNT1 mutations.
- Mice Expressing Mutant Trpv4 Recapitulate the Human TRPV4 Disorders.
- Glycerol phenylbutyrate treatment in children with urea cycle disorders: Pooled analysis of short and long-term ammonia control and outcomes.
- Differential effects of collagen prolyl 3-hydroxylation on skeletal tissues.
- Elevated phenylacetic acid levels do not correlate with adverse events in patients with urea cycle disorders or hepatic encephalopathy and can be predicted based on th...
- The genetic basis of DOORS syndrome: an exome-sequencing study.
- ADAMTS-7 forms a positive feedback loop with TNF-α in the pathogenesis of osteoarthritis.
- Notch Signaling in Skeletal Stem Cells.
- A Recurrent PDGFRB Mutation Causes Familial Infantile Myofibromatosis.
- Structure-based design and mechanisms of allosteric inhibitors for mitochondrial branched-chain α-ketoacid dehydrogenase kinase.
- Osteogenesis imperfecta without features of type V caused by a mutation in the IFITM5 gene.
- Early childhood presentation of Czech dysplasia.
- Yunis-Varón Syndrome Is Caused by Mutations in FIG4 Encoding a Phosphoinositide Phosphatase.
- E-selectin ligand 1 regulates bone remodeling by limiting bioactive TGF-? in the bone microenvironment.
- An Allelic Series of Mice Reveals a Role for RERE in the Development of Multiple Organs Affected in Chromosome 1p36 Deletions.
- Notch gain of function inhibits chondrocyte differentiation via Rbpj-dependent suppression of Sox9.
- Proteoglycan 4 expression protects against the development of osteoarthritis.
- Phenotypic variability of osteogenesis imperfecta type V caused by an IFITM5 mutation.
- Next-generation sequencing for disorders of low and high bone mineral density.
- Quantitative imaging of murine osteoarthritic cartilage by phase-contrast micro-computed tomography.
- Differential Type I Interferon-dependent Transgene Silencing of Helper-dependent Adenoviral vs. Adeno-associated Viral Vectors In Vivo.
- Deficiency of FRAS1-related extracellular matrix 1 (FREM1) causes congenital diaphragmatic hernia in humans and mice.
- WDR35 mutation in siblings with Sensenbrenner syndrome: a ciliopathy with variable phenotype.
- Contribution of LPP copy number and sequence changes to esophageal atresia, tracheoesophageal fistula, and VACTERL association.
- Response to srilatha et Al.
- Nitric-Oxide Supplementation for Treatment of Long-Term Complications in Argininosuccinic Aciduria.
- Lysinuric Protein Intolerance Presenting with Multiple Fractures.
Schools
SUNY Downstate Medical Center College Of Medicine
Baylor College Of Med
Doctors Specialties
- Clinical Biochemical Genetics
- Clinical Genetics
- Pediatrics
- Medical Genetics
Accepted Insurances
Awards
- Fellow
- Elected Member
- Fellow (FAAP)
Education
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Baylor College of Medicine -
State University of New York Downstate Medical Center College of Medicine
Hospital
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Texas Children's Hospital -
Baylor St. Luke's Medical Center
Drug Facts
| NPI NUMBER | 1033146022 | |
| NPPES Provider LastName | LEE | |
| NPPES Provider FirstName | BRENDAN | |
| NPPES Provider ZIPCode | 919423019 | |
| NPPES Provider State | CA | |
| Specialty Description | Emergency Medicine | |
| Total Claim Count | 187.0 | |
| Distinct Opioid Count | 1.0 | |
| Opioid Claim Count | 24.0 | |
| Percent Opioid Claims | 12.83 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1033146022 |
| Last Name Of The Provider | LEE |
| First Name Of The Provider | BRENDAN |
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