Professor, Internal Medicine, University of Michigan Medical School
Internal Medicine
Dr. Benjamin L. Margolis, MD
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Benjamin Margolis is an expert in the field of Internal Medicine. He received 1 awards: "Elected Member". Benjamin Margolis has written publications. He has 61 publications published with PubMed. The lastest paper is: 'Molecular analysis of the X11-mLin-2/CASK complex in brain.' He accepts Medicare.
Publications
- Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1.
- Functional analysis of the Numb phosphotyrosine-binding domain using site-directed mutagenesis.
- The membrane-associated guanylate kinase protein MAGI-1 binds megalin and is present in glomerular podocytes.
- Protein complexes that control Renal epithelial polarity.
- RPGR-ORF15, which is mutated in retinitis pigmentosa, associates With SMC1, SMC3, and microtubule transport proteins.
- Ciliary targeting of olfactory CNG channels requires the CNGB1b subunit and the kinesin-2 motor protein, KIF17.
- Loss of PALS1 expression leads to tight junction and polarity defects.
- Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97.
- Interaction of two actin-binding proteins, synaptopodin and alpha-actinin-4, With the tight junction protein MAGI-1.
- mLin-7 is localized to the basolateral surface of Renal epithelia via its NH(2) terminus.
- Insulin receptor substrate 2 and Shc play different roles in insulin-like growth factor I signaling.
- Interaction of c-Jun amino-terminal kinase interacting protein-1 With p190 rhoGEF and its localization in differentiated neurons.
- The phosphotyrosine interaction domains of X11 and FE65 bind to distinct sites on the YENPTY motif of amyloid precursor protein.
- Generation of deletion and point mutations With one primer in a single cloning step.
- Interaction With mLin-7 alters the targeting of endocytosed transmembrane proteins in mammalian epithelial cells.
- Tight junctions and cell polarity.
- PATJ regulates directional migration of mammalian epithelial cells.
- Mammalian lin-7 stabilizes polarity protein complexes.
- Composition and function of PDZ protein complexes during cell polarization.
- The Crumbs3-Pals1 complex participates in the establishment of polarity in mammalian epithelial cells.
- Human homologue of Drosophila CNK interacts With Ras effector proteins Raf and Rlf.
- Tight junction protein Par6 interacts With an evolutionarily conserved region in the amino terminus of PALS1/stardust.
- The X11alpha protein slows cellular amyloid precursor protein processing and reduces Abeta40 and Abeta42 secretion.
- The function of PTB domain proteins.
- Modulation of amyloid precursor protein Metabolism by X11alpha /Mint-1. A deletion analysis of protein-protein interaction domains.
- Molecular cloning and characterization of Pals, proteins associated With mLin-7.
- Function of PTB domains.
- The role of the Shc phosphotyrosine interaction/phosphotyrosine binding domain and tyrosine phosphorylation sites in polyoma middle T antigen-mediated cell transformat...
- The PI/PTB domain: a new protein interaction domain involved in growth factor receptor signaling.
- Molecular analysis of the X11-mLin-2/CASK complex in brain.
- Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting.
- Apical junctional complexes and cell polarity.
- ZOning out tight junctions.
- Ciliary entry of the kinesin-2 motor KIF17 is regulated by importin-beta2 and RanGTP.
- Nephrocystin-5, a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts With RPGR and calmodulin.
- The transcription factor snail represses Crumbs3 expression and disrupts apico-basal polarity complexes.
- The Ran importin system in cilia trafficking.
- SnapShot: tight and adherens junction signaling.
- Direct interaction of two polarity complexes implicated in epithelial tight junction assembly.
- Phosphorylation-dependent binding of 14-3-3 to the polarity protein Par3 regulates cell polarity in mammalian epithelia.
- Polarity proteins control ciliogenesis via kinesin motor interactions.
- Expression of Grb7 growth factor receptor signaling protein in Kidney development and in adult Kidney.
- Positive versus negative signaling of LET-23: regulation through the adaptor protein, SEM-5.
- Trafficking of Crumbs3 during cytokinesis is crucial for lumen formation.
- Apical lumen formation in Renal epithelia.
- A novel Crumbs3 isoform regulates cell division and ciliogenesis via importin beta interactions.
- PALS1 regulates E-cadherin trafficking in mammalian epithelial cells.
- Multiple regions of Crumbs3 are required for tight junction formation in MCF10A cells.
- PATJ regulates tight junction formation and polarity in mammalian epithelial cells.
- The Maguk protein, Pals1, functions as an adapter, linking mammalian homologues of Crumbs and Discs Lost.
- Septate and paranodal junctions: kissing cousins.
- Apicobasal polarity complexes.
- Cell dynamics in fetal intestinal epithelium: implications for intestinal growth and morphogenesis.
- Localization of retinitis pigmentosa 2 to cilia is regulated by Importin beta2.
- Retinitis Pigmentosa GTPase Regulator (RPGR) protein isoforms in mammalian retina: insights into X-linked Retinitis Pigmentosa and associated ciliopathies.
- Mammalian Crumbs3 is a small transmembrane protein linked to protein associated With Lin-7 (Pals1).
- The carboxyl terminus of zona occludens-3 binds and recruits a mammalian homologue of discs lost to tight junctions.
- A novel and conserved protein-protein interaction domain of mammalian Lin-2/CASK binds and recruits SAP97 to the lateral surface of epithelia.
- The retinitis pigmentosa protein RP2 interacts With polycystin 2 and regulates cilia-mediated vertebrate development.
- Induction of Ran GTP drives ciliogenesis.
Schools
University Of Manitoba Faculty Of Medicine
University Tex Health Science Center
University Toronto
Procedures Preformed
- Hemodialysis
Conditions Treated
- Acute Glomerulonephritis
- Acute Kidney Failure
- Alkalosis
- Amyloidosis
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Doctors Specialties
- Nephrology
- Internal Medicine
Accepted Insurances
Awards
- Elected Member
Education
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University of Texas Health Science Center -
University of Manitoba
Hospital
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University of Michigan Hospitals and Health Centers -
Rush Oak Park Hospital
Drug Facts
| NPI NUMBER | 1013099928 | |
| NPPES Provider LastName | MARGOLIS | |
| NPPES Provider FirstName | BENJAMIN | |
| NPPES Provider ZIPCode | 481095364 | |
| NPPES Provider State | MI | |
| Specialty Description | Nephrology | |
| Total Claim Count | 16.0 | |
| Distinct Opioid Count | 0.0 | |
| Opioid Claim Count | 0.0 | |
| Percent Opioid Claims | 0.0 |
Helpful Reviews
Medicare Facts
| National Provider Identifier [NPI] | 1013099928 |
| Last Name Of The Provider | MARGOLIS |
| First Name Of The Provider | BENJAMIN |
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