Associate Professor, Medicine, University of Washington School of Medicine

Hematology

Antonio Bedalov is an expert in the field of Hematology. He researched medicine at Baylor College of Medicine. Antonio A. Bedalov is a published MD. He published 43 publications, including: '1,25-Dihydroxyvitamin D3 inhibition of col1a1 promoter expression in calvariae from neonatal transgenic mice.'

Publications

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• The Androgen-Regulated Protease TMPRSS2 Activates a Proteolytic Cascade Involving Components of the Tumor Microenvironment and Promotes Prostate Cancer Metastasis.
• Development of Pyrazolone and Isoxazol-5-one Cambinol Analogues as Sirtuin Inhibitors.
• A Natural Polymorphism in rDNA Replication Origins Links Origin Activation with Calorie Restriction and Lifespan.
• Proteomic Classification of Acute Leukemias by Alignment-Based Quantitation of LC-MS/MS Data Sets.
• Sirtuins in yeast: phenotypes and tools.
• Identification and characterization of Sir2 inhibitors through phenotypic assays in yeast.
• Neuroscience. NAD to the rescue.
• Yeast as a model System for anticancer drug discovery.
• Inhibitors of Sir2: evaluation of splitomicin analogues.
• Identification of selective inhibitors of NAD+-dependent deacetylases using phenotypic screens in yeast.
• NAD+-dependent deacetylase Hst1p controls biosynthesis and Cellular NAD+ levels in Saccharomyces cerevisiae.
• Sir2 flexes its muscle.
• SIRT1 is dispensable for function of hematopoietic stem Cells in adult mice.
• Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.
• Genetic variation shapes protein networks mainly through non-transcriptional mechanisms.
• Natural polymorphism in BUL2 links Cellular amino acid availability with chronological aging and telomere maintenance in yeast.
• Sirtuin modulators.
• SIRT1 Promotes N-Myc Oncogenesis through a Positive Feedback Loop Involving the Effects of MKP3 and ERK on N-Myc Protein Stability.
• Conditioning with treosulfan and fludarabine followed by allogeneic hematopoietic Cell transplantation for high-risk hematologic malignancies.
• Identification of inhibitors of chromatin modifying enzymes using the yeast phenotypic screens.
• IntraCellular NAD levels regulate tumor necrosis factor protein synthesis in a sirtuin-dependent manner.
• Identification and characterization of small-molecule inhibitors of hepsin.
• Identification of small molecule inhibitors of Pseudomonas aeruginosa exoenzyme S using a yeast phenotypic screen.
• Hst3 is regulated by Mec1-dependent proteolysis and controls the S phase checkpoint and sister chromatid cohesion by deacetylating histone H3 at lysine 56.
• Genetic basis of proteome variation in yeast.
• Hematopoietic cell transplantation in patients with myelodysplastic syndrome or Acute myeloid leukemia arising from myelodysplastic syndrome: similar outcomes in patie...
• Pharmacogenetics: yeast lead the way.
• Antitumor activity of a small-molecule inhibitor of human silent information regulator 2 enzymes.
• Telomere length as a quantitative trait: genome-wide survey and genetic mapping of telomere length-control genes in yeast.
• Substrate-specific activation of sirtuins by resveratrol.
• Regulation of type I collagen gene expression in bone.
• Identification of a small molecule inhibitor of Sir2p.
• 1,25-Dihydroxyvitamin D3 inhibition of col1a1 promoter expression in calvariae from neonatal transgenic mice.
• Glucocorticoid-induced ketoacidosis in gestational diabetes: sequela of the Acute treatment of preterm labor. A case report.
• Regulation of COL1A1 expression in type I collagen producing tissues: identification of a 49 base pair region which is required for transgene expression in bone of tra...
• Identification of a TAAT-containing motif required for high level expression of the COL1A1 promoter in differentiated osteoblasts of transgenic mice.
• Differences in regulation of alpha 1(I) collagen promoter in vascular smooth muscle Cells in transfection studies and transgenic mice.
• Regulation of the alpha 1(I) collagen promoter in vascular smooth muscle Cells. Comparison with other alpha 1(I) collagen-producing Cells in transgenic animals and cul...
• Upstream regulatory elements necessary for expression of the rat COL1A1 promoter in transgenic mice.
• Analysis of regulatory regions in the COL1A1 gene responsible for 1,25-dihydroxyvitamin D3-mediated transcriptional repression in osteoblastic Cells.
• Identification of regulatory elements necessary for the expression of the COL1A1 promoter in murine odontoblasts.
• Differential utilization of regulatory domains within the alpha 1(I) collagen promoter in osseous and fibroblastic Cells.

Schools

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• University of Zagrebu Medical College

• Baylor College Of Med

• University Washington

Procedures Preformed

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• Cardiac MRI (Magnetic Resonance Imaging) of Heart or Chest
• HPC Transplantation (Stem Cell Transplant)
• Thoracentesis

Conditions Treated

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• Acute Leukemia
• Anemia
• Brain and Nervous System Cancer (incl. Gliomas, Astrocytoma, Schwannoma, Medulloblastoma, Chordoma)
• Brain Cancer
• View All

Doctors Specialties

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• Medical Oncology
• Oncology
• Hematology

Accepted Insurances

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Education

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• University of Washington
• Baylor College of Medicine
• University of Zagreb Faculty of Medicine

Hospital

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• UW Medicine/Harborview Medical Center
• University of Washington Medical Center

Helpful Reviews

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Medicare Facts

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National Provider Identifier [NPI]	1407844467
Last Name Of The Provider	BEDALOV
First Name Of The Provider	ANTONIO
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