Professor, Pathology, UCSF School of Medicine

Pathology

Abul K. Abbas, MD practices Pathology. He received 1 awards: "Elected Member". Abul K. Abbas, MD has written publications. He has 102 publications published with PubMed. The lastest publication is: 'Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo.'

Publications

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• Cutting Edge: Regulatory T Cells Facilitate Cutaneous Wound Healing.
• A Wave of Regulatory T Cells into Neonatal Skin Mediates Tolerance to Commensal Microbes.
• Cutting Edge: Self-Antigen Controls the Balance between Effector and Regulatory T Cells in Peripheral Tissues.
• Cutting Edge: Memory Regulatory T Cells Require IL-7 and Not IL-2 for Their Maintenance in Peripheral Tissues.
• Regulatory T cells: recommendations to simplify the nomenclature.
• The life of regulatory T cells.
• IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells.
• Response to self antigen imprints regulatory memory in tissues.
• A network of regulatory pathways in lepromatous leprosy.
• Opposing functions of IL-2 and IL-7 in the regulation of immune responses.
• Differential requirements for Th1 and th17 responses to a systemic self-antigen.
• Posttranscriptional silencing of effector cytokine mRNA underlies the anergic phenotype of self-reactive T cells.
• Cutting edge: mechanisms of IL-2-dependent maintenance of functional regulatory T cells.
• STAT1-activating cytokines limit Th17 responses through both T-bet-dependent and -independent mechanisms.
• Duration of antigen receptor signaling determines T-cell tolerance or activation.
• Revisiting the role of IL-2 in autoimmunity.
• Cutting edge: the Th1 response inhibits the generation of peripheral regulatory T cells.
• The initial phase of an immune response functions to activate regulatory T cells.
• Retraction. Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.
• Retraction. Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes.
• Retraction. The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens.
• Balance of Th1 and Th17 effector and peripheral regulatory T cells.
• Distinct roles of helper T-cell subsets in a systemic autoimmune disease.
• Ctla-4 controls regulatory T cell peripheral homeostasis and is required for suppression of pancreatic islet autoimmunity.
• Interleukin-2 in the development and control of inflammatory disease.
• Cutting edge: contributions of apoptosis and anergy to systemic T cell tolerance.
• Pillars article: Antigen presentation by hapten-specific B lymphocytes. I. Role of surface immunoglobulin receptors. 1984.
• Role of T cells in a murine model of Escherichia coli sepsis.
• Targeting T cell-specific costimulators and growth factors in a model of autoimmune hemolytic anemia.
• Constitutive expression of B7-1 on B cells uncovers autoimmunity toward the B cell compartment in the nonobese diabetic mouse.
• Interleukin-2 enhances CD4+ T cell memory by promoting the generation of IL-7R alpha-expressing cells.
• Balancing autoaggressive and protective T cell responses.
• Role of IL-17 and regulatory T lymphocytes in a systemic autoimmune disease.
• T-cell costimulation--biology, therapeutic potential, and challenges.
• Regulatory T cells in the periphery.
• Inhibition of T cell activation and autoimmune diabetes using a B cell surface-linked CTLA-4 agonist.
• Control of CD4+ T-cell memory by cytokines and costimulators.
• Functional and molecular comparison of anergic and regulatory T lymphocytes.
• Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen.
• B7-independent inhibition of T cells by CTLA-4.
• The link between lymphocyte deficiency and autoimmunity: roles of endogenous T and B lymphocytes in tolerance.
• Paths to understanding the genetic basis of autoimmune disease.
• T-cell tolerance and autoimmunity to systemic and tissue-restricted self-antigens.
• Dendritic cells giveth and taketh away.
• T cell tolerance and autoimmunity.
• Role of B7 in T cell tolerance.
• CD4+CD25+ cells controlling a pathogenic CD4 response inhibit cytokine differentiation, CXCR-3 expression, and tissue invasion.
• Cooperative roles of CTLA-4 and regulatory T cells in tolerance to an islet cell antigen.
• IL-2 induces a competitive survival advantage in T lymphocytes.
• CD28 signals in the immature immunological synapse.
• Distinct regions in the CD28 cytoplasmic domain are required for T helper type 2 differentiation.
• Antigen-dependent proliferation of CD4+ CD25+ regulatory T cells in vivo.
• The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens.
• The activation of lymphocytes is in their CARMA.
• The control of T cell activation vs. tolerance.
• Natural versus adaptive regulatory T cells.
• CTLA-4 differentially regulates T cell responses to endogenous tissue protein versus exogenous immunogen.
• Interferon gamma is required for activation-induced death of T lymphocytes.
• Functional tolerance is maintained despite proliferation of CD4 T cells after encounter with tissue-derived antigen.
• Life and death in effector T cells.
• The enemy within: keeping self-reactive T cells at bay in the periphery.
• CTLA-4 regulates induction of anergy in vivo.
• Akt provides the CD28 costimulatory signal for up-regulation of IL-2 and IFN-gamma but not TH2 cytokines.
• Expression of bcl-X(L) restores cell survival, but not proliferation off effector differentiation, in CD28-deficient T lymphocytes.
• The roles of CD28 and CD40 ligand in T cell activation and tolerance.
• Immunology: improving on nature in the twenty-first century.
• Functional responses and costimulator dependence of memory CD4+ T cells.
• T-cell stimulation: an abundance of B7s.
• Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes.
• Uncoupling IL-2 signals that regulate T cell proliferation, survival, and Fas-mediated activation-induced cell death.
• The role of CTLA-4 in regulating Th2 differentiation.
• Genetic models of abnormal apoptosis in lymphocytes.
• Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo.
• Mechanisms of peripheral T cell tolerance.
• Role of cytokines in autoimmunity.
• Role of mu heavy chain in B cell development. I. Blocked B cell maturation but complete allelic exclusion in the absence of Ig alpha/beta.
• Helper T cell subsets: heterogeneity, functions and development.
• Biochemical mechanisms of IL-2-regulated Fas-mediated T cell apoptosis.
• Homeostasis and self-tolerance in the immune system: turning lymphocytes off.
• Functional roles of Fas and Bcl-2-regulated apoptosis of T lymphocytes.
• The Fas/Fas ligand pathway and Bcl-2 regulate T cell responses to model self and foreign antigens.
• Functional consequences of dysregulated B7-1 (CD80) and B7-2 (CD86) expression in B or T lymphocytes of transgenic mice.
• Role of interleukin 12 and costimulators in T cell anergy in vivo.
• Functional responses and apoptosis of CD25 (IL-2R alpha)-deficient T cells expressing a transgenic antigen receptor.
• T-cell subsets: recruiting the right kind of help.
• Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement.
• Role of costimulators in T cell differentiation: studies using antigen-presenting cells lacking expression of CD80 or CD86.
• Functional diversity of helper T lymphocytes.
• Cytokine transcriptional events during helper T cell subset differentiation.
• Role of Fas-mediated cell death in the regulation of immune responses.
• Die and let live: eliminating dangerous lymphocytes.
• The roles of costimulation and Fas in T cell apoptosis and peripheral tolerance.
• IL-12, as an adjuvant, promotes a T helper 1 cell, but does not suppress a T helper 2 cell recall response.
• T cell responses in calcineurin A alpha-deficient mice.
• Anatomy of autoantibody production: dominant localization of antibody-producing cells to T cell zones in Fas-deficient mice.
• Stability of Th1 and Th2 populations.
• Intracellular targeting of antigens internalized by membrane immunoglobulin in B lymphocytes.
• Differentiation and tolerance of CD4+ T lymphocytes.
• Molecular mechanisms that control expression of the B lymphocyte antigen receptor complex.
• Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model.
• Regulatory T cell memory.

Doctors Specialties

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• Anatomic Pathology
• Pathology

Accepted Insurances

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Awards

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• Elected Member

Education

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• Brigham and Women's Hospital

Hospital

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• San Francisco General Hospital and Trauma Center
• UCSF Medical Center

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